Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
iTeos Reports Positive Objective Response Rate in GALAXIES Lung-201 Study
Details : EOS-448 (belrestotug, TIGIT antibody) with dostarlimab is being investigated for previously untreated, unresectable, locally advanced or metastatic PD-L1 selected NSCLC.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 14, 2024
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : GSK
Deal Size : $2,075.0 million
Deal Type : Collaboration
iTeos Doses First Patient in GALAXIES Lung-301 Phase 3, Earns $35M from GSK
Details : The collaboration aims to advance the clinical development of late-stage product EOS-448 (belrestotug) in combination with Dostarlimab for the treatment of PD-L1 high Non-small Cell Lung Cancer.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : $625.0 million
July 08, 2024
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : GSK
Deal Size : $2,075.0 million
Deal Type : Collaboration
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
iTeos and GSK Launch Phase 3 Study on Belrestotug and Dostarlimab in Lung Cancer
Details : Antibody combination, EOS-448 (belrestotug) with dostarlimab is being investigated in patients with previously untreated, unresectable, locally advanced or metastatic PD-L1 selected NSCLC.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 17, 2024
Lead Product(s) : Belrestotug,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Belrestotug,GSK6097608,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : RA Capital Management
Deal Size : $120.0 million
Deal Type : Public Offering
iTeos Therapeutics Announces $120 Million Registered Direct Offering
Details : The net proceeds from the financing are used to advance the clinical development of EOS-448 (belrestotug) in combination with GSK6097608 and Dostarlimab for non-small cell lung cancer.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : Undisclosed
May 10, 2024
Lead Product(s) : Belrestotug,GSK6097608,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : RA Capital Management
Deal Size : $120.0 million
Deal Type : Public Offering
Lead Product(s) : EOS-984
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iTeos Presents EOS-984 Preclinical Data Showing T Cell Activity Restoration
Details : EOS-984 is a potential first-in-class small molecule inhibitor targeting the equilibrative nucleoside transporter 1 (ENT1). It is being evaluated for the treatment of triple negative breast cancer.
Brand Name : EOS-984
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 07, 2024
Lead Product(s) : EOS-984
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : EOS-448,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : In preclinical studies and in blood samples from patients with cancer, treatment with EOS-448 (GSK4428859A) results reduction in suppressive and exhausted immune cell populations, indicating engagement of FcγR, an essential component in many immune syst...
Brand Name : GSK4428859A
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 08, 2022
Lead Product(s) : EOS-448,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : GSK
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : EOS-448,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : GSK
Deal Size : $2,075.0 million
Deal Type : Collaboration
GSK Pays Up Big for Rights To TIGIT-Targeted Cancer Immunotherapy from Iteos
Details : The addition of EOS-448 results in GSK being the only company with antibodies targeting all three known checkpoints – TIGIT (via EOS-448), CD96 (via GSK’608), and PVRIG (via GSK’562).
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : $625.0 million
June 14, 2021
Lead Product(s) : EOS-448,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : GSK
Deal Size : $2,075.0 million
Deal Type : Collaboration
Details : Initial data from the Phase 1 dose escalation part of the Phase 1/2a trial in adult patients with advanced solid tumors indicated EOS-448 was generally well tolerated with no dose-limiting toxicities observed.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 10, 2021
Lead Product(s) : EOS-850
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : $100.0 million
Deal Type : Public Offering
Phase 1/2 oncology biotech iTeos Therapeutics files for a $100 million IPO
Details : The company's lead candidate EOS-850, a highly selective small molecule antagonist of the adenosine A2a receptor (A2AR), is in an open-label Phase 1/2 clinical trial in adult patients with advanced solid tumors, with initial data expected in the 1H 2021.
Brand Name : EOS-850
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 24, 2020
Lead Product(s) : EOS-850
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : $100.0 million
Deal Type : Public Offering
Lead Product(s) : EOS-448
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : EOS-448 is being investigated in a Phase 1/2a clinical trial in advanced solid tumors and the dose escalation portion of the trial was initiated in February 2020.
Brand Name : EOS-448
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 22, 2020
Lead Product(s) : EOS-448
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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