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    [{"orgOrder":0,"company":"IVERIC bio","sponsor":"Astellas Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Astellas Pharma","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Astellas Pharma"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Astellas Pharma","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Acquisition","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC 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Capital","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Financing","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Hercules Capital","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Hercules Capital"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC 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bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC 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bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC 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bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"DelSiTech","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Agreement","leadProduct":"Avacincaptad Pegol","moa":"C5 receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ DelSiTech","highestDevelopmentStatusID":"10","companyTruncated":"IVERIC bio \/ DelSiTech"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Opus Genetics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Acquisition","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"IVERIC bio \/ Opus Genetics","highestDevelopmentStatusID":"4","companyTruncated":"IVERIC bio \/ Opus Genetics"}]

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                            01

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Astellas Completes Acquisition of Iveric Bio

                            Details : Through the acquisition, Astellas expands its ophthalmology pipeline through Iveric Bio's promising programs, including Zimura (avacincaptad pegol), an important program for Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : $5,900.0 million

                            November 07, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

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                            02

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Astellas Pharma

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Positive 24-Month Topline Results from Phase 3 Study of IZERVAY™ (avacincaptad pegol in...

                            Details : IZERVAY™ (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            September 18, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Astellas Pharma

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Astellas Enters Into Definitive Agreement to Acquire Iveric Bio

                            Details : Through the acquisition, Astellas will expand its ophthalmology pipeline through Iveric Bio's promising programs, including Zimura (avacincaptad pegol), an important program for Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : $5,900.0 million

                            April 30, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

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                            04

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces FDA Accepts New Drug Application and Grants Priority Review for Avacincaptad Pegol for th...

                            Details : Zimura (avacincaptad pegol) is a novel complement C5 protein inhibitor by targeting C5, ACP has the potential to decrease activity of the complement system that causes the degeneration of retinal cells and potentially slow the progression of GA.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            February 16, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Vision Loss Reduction Data in Geographic Atrophy from Avacincaptad Pegol GATHER Trials

                            Details : Zimura (avacincaptad pegol) is a novel complement C5 protein inhibitor having the potential to decrease activity of the complement system that causes the degeneration of retinal cells and potentially slow the progression of geographic atrophy.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            January 03, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Opus Genetics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Opus Genetics Announces Acquisition of the Rights to Two Gene Therapy Product Candidates for Inherited Retinal...

                            Details : Opus Genetics' AAV-based gene therapy portfolio tackles some of the most neglected forms of inherited blindness while creating novel orphan manufacturing scale and efficiencies.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $0.5 million

                            December 28, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Opus Genetics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            07

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Completion of Rolling NDA Submission to FDA for Avacincaptad Pegol for the Treatment of G...

                            Details : Zimura (avacincaptad pegol), is an investigational drug that has not yet been evaluated by any regulatory body for safety and efficacy. ACP is not authorized for any indication in any country.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 20, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces FDA Has Granted Breakthrough Therapy Designation for Avacincaptad Pegol for Geographic At...

                            Details : Zimura (ACP) is novel complement C5 protein inhibitor. Overactivity of the complement system and the C5 protein are suspected to play a critical role in development and growth of scarring and vision loss associated with GA secondary to AMD.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            November 17, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            IVERIC bio

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                            AACR Annual meeting
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                            IVERIC bio

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                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Presentation of Post-Hoc Analysis at Macula Society from GATHER1 Clinical Trial of Zimura...

                            Details : Zimura (avacincaptad pegol) is an investigational drug product and has not been approved for use anywhere globally. Zimura is designed to target and inhibit cleavage of complement protein C5 and formation of its downstream fragments, C5a and C5b.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            October 06, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            IVERIC bio

                            U.S.A arrow
                            AACR Annual meeting
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                            IVERIC bio

                            U.S.A arrow
                            AACR Annual meeting
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            Iveric Bio Announces Agreement for Up to $250 Million in Non-Dilutive Debt Financing with Hercules Capital and...

                            Details : The non-dilutive financing will strengthen the balance sheet and provides financial flexibility as to fund the potential commercial launch of Zimura® (avacincaptad pegol) in geographic atrophy (GA) in the United States, subject to regulatory approval.

                            Product Name : Zimura

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            July 26, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

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