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    [{"orgOrder":0,"company":"IVERIC bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Avacincaptad Pegol","moa":"Completent C5","graph1":"Ophthalmology","graph2":"Approved","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Not Applicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Avacincaptad Pegol","moa":"Completent C5","graph1":"Ophthalmology","graph2":"Approved","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Not Applicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Avacincaptad Pegol","moa":"Completent C5","graph1":"Ophthalmology","graph2":"Approved","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Not Applicable"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Not 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bio","amount2":5.9000000000000004,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":5.9000000000000004,"dosageForm":"Injectable\/Injection","sponsorNew":"IVERIC bio \/ Astellas Pharma","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Astellas Pharma"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Astellas Pharma","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Large molecule","year":"2023","type":"Acquisition","leadProduct":"Avacincaptad Pegol","moa":"","graph1":"Ophthalmology","graph2":"Approved","graph3":"IVERIC bio","amount2":5.9000000000000004,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":5.9000000000000004,"dosageForm":"Injectable\/Injection","sponsorNew":"IVERIC bio \/ Astellas Pharma","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Astellas Pharma"},{"orgOrder":0,"company":"IVERIC 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bio","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"IVERIC bio \/ Astellas Pharma","highestDevelopmentStatusID":"12","companyTruncated":"IVERIC bio \/ Astellas Pharma"}]

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                            01

                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Astellas Pharma

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Positive 24-Month Topline Results from Phase 3 Study of IZERVAY™ (avacincaptad pegol in...

                            Details : IZERVAY™ (avacincaptad pegol intravitreal solution), a complement C5 inhibitor for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                            Brand Name : Izervay

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 18, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Astellas Pharma

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Recipient : Astellas Pharma

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            European Medicines Agency Accepts Iveric Bio’s Marketing Authorization Application for Avacincaptad Pegol fo...

                            Details : Izervay (avacincaptad pegol intravitreal solution) act as completent C5 inhibitor that is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

                            Brand Name : Izervay

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 18, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Recipient : Astellas Pharma

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Astellas Completes Acquisition of Iveric Bio

                            Details : Through the acquisition, Astellas expands its ophthalmology pipeline through Iveric Bio's promising programs, including Zimura (avacincaptad pegol), an important program for Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : $5,900.0 million

                            July 11, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

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                            04

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Astellas Enters Into Definitive Agreement to Acquire Iveric Bio

                            Details : Through the acquisition, Astellas will expand its ophthalmology pipeline through Iveric Bio's promising programs, including Zimura (avacincaptad pegol), an important program for Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : $5,900.0 million

                            April 30, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Astellas Pharma

                            Deal Size : $5,900.0 million

                            Deal Type : Acquisition

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                            05

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Vision Loss Reduction Data in Geographic Atrophy from Avacincaptad Pegol GATHER Trials

                            Details : Zimura (avacincaptad pegol) is a novel complement C5 protein inhibitor having the potential to decrease activity of the complement system that causes the degeneration of retinal cells and potentially slow the progression of geographic atrophy.

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 01, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces FDA Accepts New Drug Application and Grants Priority Review for Avacincaptad Pegol for th...

                            Details : Zimura (avacincaptad pegol) is a novel complement C5 protein inhibitor by targeting C5, ACP has the potential to decrease activity of the complement system that causes the degeneration of retinal cells and potentially slow the progression of GA.

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 16, 2023

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : AAv-based Gene Therapy

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Opus Genetics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Opus Genetics Announces Acquisition of the Rights to Two Gene Therapy Product Candidates for Inherited Retinal...

                            Details : Opus Genetics' AAV-based gene therapy portfolio tackles some of the most neglected forms of inherited blindness while creating novel orphan manufacturing scale and efficiencies.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : $0.5 million

                            December 28, 2022

                            Lead Product(s) : AAv-based Gene Therapy

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Opus Genetics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            08

                            IVERIC bio

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                            IVERIC bio

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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Iveric Bio Announces Completion of Rolling NDA Submission to FDA for Avacincaptad Pegol for the Treatment of G...

                            Details : Zimura (avacincaptad pegol), is an investigational drug that has not yet been evaluated by any regulatory body for safety and efficacy. ACP is not authorized for any indication in any country.

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 20, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            IVERIC bio

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                            IVERIC bio

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                            • EDQM
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                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Iveric Bio Announces FDA Has Granted Breakthrough Therapy Designation for Avacincaptad Pegol for Geographic At...

                            Details : Zimura (ACP) is novel complement C5 protein inhibitor. Overactivity of the complement system and the C5 protein are suspected to play a critical role in development and growth of scarring and vision loss associated with GA secondary to AMD.

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 17, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            IVERIC bio

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                            Pharmtech & Ingredients
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                            IVERIC bio

                            U.S.A arrow
                            Pharmtech & Ingredients
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Iveric Bio Announces Positive Topline Data from Zimura® GATHER2 Phase 3 Clinical Trial in Geographic Atrophy

                            Details : Zimura (avacincaptad pegol) showed Primary Endpoint Met with 14.3% Reduction (p-value = 0.0064) in Mean Rate of Growth (Slope) in GA Area Over 12 Months Using Square Root Transformation; 17.7% Reduction (p-value = 0.0039) Using Observed GA Area

                            Brand Name : Zimura

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 06, 2022

                            Lead Product(s) : Avacincaptad Pegol

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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