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Science Fund"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"JW Therapeutics","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"JW Therapeutics Acquires Syracuse Biopharma and License to Eureka Therapeutics\u2019 Solid Tumor Technology in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Discovery Platform","country":"HONG KONG","productType":"Cell and Gene therapy","productStatus":"Undisclosed","date":"July 2020","year":"2020","type":"Acquisition","leadProduct":"T-cell therapy","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"Discovery Platform","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Discovery Platform","highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"JW Therapeutics \/ JW Therapeutics","highestDevelopmentStatusID":"3","companyTruncated":"JW Therapeutics \/ JW Therapeutics"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Goldman Sachs","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"JW Therapeutics Hauls in $300M IPO Just as Liso-Cel-Inspired CAR-T Nears the Finish Line in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"IND Enabling","country":"","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"November 2020","year":"2020","type":"Public Offering","leadProduct":"Relmacabtagene autoleucel","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"IND Enabling","highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"JW Therapeutics \/ Goldman Sachs","highestDevelopmentStatusID":"5","companyTruncated":"JW Therapeutics \/ Goldman Sachs"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Thermo Fisher Scientific","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"JW Therapeutics and Thermo Fisher Scientific Announce CAR-T Partnership in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"February 2021","year":"2021","type":"Partnership","leadProduct":"Relmacabtagene autoleucel","moa":"CD19","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Phase II","highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"JW Therapeutics \/ JW Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"JW Therapeutics \/ JW Therapeutics"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"JW Therapeutics Claims Approval of Autoleucel Relmacabtagen Injection in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"","productType":"Cell and Gene therapy","productStatus":"Approved","date":"September 2021","year":"2021","type":"Not Applicable","leadProduct":"Autoleucel Relmacabtagen","moa":"CD19","url1":"","url2":"","graph1":"Oncology","graph2":"Approved","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Approved","highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"JW Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"JW Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"JW Therapeutics Announces IND Approval for the Pivotal Clinical Trial of Carteyva\u00ae in Second-line Large B-Cell Lymphoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"","productType":"Cell and Gene therapy","productStatus":"Approved","date":"March 2022","year":"2022","type":"Not Applicable","leadProduct":"Relmacabtagene Autoleucel","moa":"CD19","url1":"","url2":"","graph1":"Oncology","graph2":"Approved","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Approved","highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"JW Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"JW Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"JW Therapeutics Announces Receipt of Breakthrough Therapy Designation for Carteyva\u00ae in Mantle Cell Lymphoma in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"","productType":"Cell and Gene therapy","productStatus":"Approved","date":"April 2022","year":"2022","type":"Not Applicable","leadProduct":"Relmacabtagene Autoleucel","moa":"","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"Phase II","highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"Subcutaneous injection","sponsorNew":"JW Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"JW Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"JW Therapeutics Announces IND Approval for the Clinical Trial of Carteyva\u00ae in Pediatric and Young Adult Patients with Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia","therapeuticArea":"Oncology","highestDevelopmentStatus":"IND Enabling","country":"","productType":"Cell and Gene therapy","productStatus":"Approved","date":"April 2022","year":"2022","type":"Not Applicable","leadProduct":"Relmacabtagene Autoleucel","moa":"CD19","url1":"","url2":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"JW Therapeutics","amount2":0,"therapeuticAreaNew":"Oncology","highestDevelopmentStatusNew":"IND Enabling","highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","productSubType":"","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"JW Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"JW Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"JW Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"JW Therapeutics Announces NMPA Approval of Relmacabtagene Autoleucel Injection in Patients with Relapsed or Refractory Follicular Lymphoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"","productType":"Cell and Gene therapy","productStatus":"Approved","date":"October 2022","year":"2022","type":"Not Applicable","leadProduct":"Relmacabtagene Autoleucel","moa":"CD19","url1":"","url2":"","graph1":"Oncology","graph2":"Approved","graph3":"JW 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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Carteyva (relmacabtagene autoleucel) is an anti-CD19 CAR-T approved for the treatment of adult patients with relapsed or refractory Mantle Cell Lymphoma (r/r MCL).

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 27, 2024

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Relma-cel (relmacabtagene autoleucel) is based on the same chimeric antigen receptor (CAR) construct, currently beinf investigated in patients with moderately or severely refractory systemic lupus erythematosus.

                          Brand Name : Relma-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 10, 2023

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Carteyva® (relmacabtagene autoleucel) is an autologous anti-CD19 CAR-T cell immunotherapy, which has been approved for relapsed or refractory large B-cell lymphoma and refractory follicular lymphoma.

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 08, 2023

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : JWATM214 is an autologous T-cell immunotherapy candidate drug targeting GPC-3 to delay T cell exhaustion, to achieve more durable and superior anti-tumor activity, potentially providing novel treatment for GPC-3-expressing advanced HCC patients.

                          Brand Name : JWATM214

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 28, 2023

                          Lead Product(s) : JWATM214

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : The initial focus of the collaboration is 2seventy bio’s MAGE-A4 TCR program in solid tumors which is being developed as part of a collaboration with Regeneron. MAGE-A4 is a member of the MAGE family of cancer-testis antigens expressed in a number of s...

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 27, 2022

                          Lead Product(s) : TCR T-cell Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : 2Seventy Bio

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          06

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Cohort B results showed that Carteyva® (relmacabtagene autoleucel) demonstrated very high rates of durable disease response (ORR)=100%, (CRR)=85.19% at month 3; ORR=92.58%, CRR=77.78% at month 6) and controllable CAR-T associated toxicities in patients ...

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 10, 2022

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : The approval of Carteyva (relmacabtagene autoleucel (relma-cel) injection), an autologous anti-CD19 CAR-T cell immunotherapy product is based on results of a RELIANCE study in treating pediatric and young adult patients with r/r B-ALL.

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 20, 2022

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Breakthrough Therapy Designation was supported by results from clinical study of Carteyva (relmacabtagene autoleucel) in relapsed or refractory MCL (r/r MCL), which aimed to assess the efficacy and safety of Carteyva® in adults with r/r MCL in China.

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 03, 2022

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : Carteyva® (relmacabtagene autoleucel injection) also abbreviated as relma-cel,an autologous anti-CD19 CAR-T cell immunotherapy product, in the treatment of second-line large B-Cell lymphoma.

                          Brand Name : Carteyva

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 31, 2022

                          Lead Product(s) : Relmacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Luxepack
                          Not Confirmed
                          Luxepack
                          Not Confirmed

                          Details : China NMPA has approved an application for registration of a new drug autoleucel relmacabtagen for the treatment of adult patients with recurrent or refractory large B-cell lymphoma (r / r HCL) after two or more lines of systemic therapy.

                          Brand Name : JWCAR029

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 06, 2021

                          Lead Product(s) : Autoleucel Relmacabtagen

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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