Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Ocedurenone
Therapeutic Area : Nephrology
Study Phase : Phase III
Sponsor : Novo Nordisk
Deal Size : $1,300.0 million
Deal Type : Acquisition
Novo Nordisk to Acquire Ocedurenone for Uncontrolled Hypertension from KBP Biosciences
Details : Through the acquisition, Novo Nordisk gains access to KBP-5074 (ocedurenone), an orally administered, small molecule, non-steroidal mineralocorticoid receptor antagonist (nsMRA), for uncontrolled hypertension with potential application in cardiovascular ...
Brand Name : KBP-5074
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 16, 2023
Lead Product(s) : Ocedurenone
Therapeutic Area : Nephrology
Highest Development Status : Phase III
Sponsor : Novo Nordisk
Deal Size : $1,300.0 million
Deal Type : Acquisition
Lead Product(s) : Ocedurenone
Therapeutic Area : Nephrology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : KBP-5074 (ocedurenone) is a non-steroidal MRA which selectively binds to recombinant human MRs with much higher affinity than to recombinant human glucocorticoid, progesterone, and androgen receptors which can produce antihypertensive, renal and cardiopr...
Brand Name : KBP-5074
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 06, 2023
Lead Product(s) : Ocedurenone
Therapeutic Area : Nephrology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-5074
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The Phase 2b clinical trial met its primary endpoint, with KBP-5074 demonstrating a clinically and statistically significant improvement in systolic blood pressure (SBP) from baseline to day 84 in Stage 3b/4 CKD patients with uncontrolled hypertension.
Brand Name : KBP-5074
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 07, 2020
Lead Product(s) : KBP-5074
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Study Phase : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
KBP Biosciences Announces Data Presentation at the American Society of Nephrology Annual Meeting
Details : The upcoming data to be presented at the American Society of Nephrology (ASN) Annual Meeting showcases a pre-clinical study investigating the effect of KBP-5074 on aldosterone-mediated renal injury in the uninephrectomized SD rat CKD model.
Brand Name : KBP-5074
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 22, 2020
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Study Phase : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BLOCK-CKD is a Phase 2b, international, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of KBP-5074, on top of current therapy, in patients with Stage 3B/4 CKD and uncontrolled hypertens...
Brand Name : KBP-5074
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 29, 2020
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Study Phase : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Single doses of 0.5 mg KBP-5074 were generally well tolerated in patients with severe CKD, with or without hemodialysis . Overall drug exposure was significantly lower in hemodialyzed patients vs. non-hemodialyzed patients.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 21, 2020
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Study Phase : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
KBP Biosciences Completes Enrollment of BLOCK CKD Phase 2b Study of KBP-5074
Details : BLOCK CKD is a randomized, double-blind, placebo-controlled, multi-center study to assess the efficacy, safety, and pharmacokinetics of KBP-5074 in patients with moderate-to-severe CKD and uncontrolled hypertension.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 20, 2020
Lead Product(s) : KBP-5074
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Sponsor : Labcorp Drug Development
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KBP-7072
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : KBP-7072 demonstrated potent activity against geographically-diverse strains of A. baumannii including carbapenem-resistant, colistin-resistant and tetracycline-resistant isolates.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 28, 2020
Lead Product(s) : KBP-7072
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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