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Agreement with Sanofi for T-cell Engagers","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"August 2024","year":"2024","type":"Licensing Agreement","leadProduct":"AMX-818","moa":"","url1":"","url2":"","graph1":null,"graph2":null,"graph3":"Sanofi","amount2":0,"therapeuticAreaNew":null,"highestDevelopmentStatusNew":null,"highestDevelopmentShortName":null,"therapeuticAreaShortName":null,"productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"Sanofi \/ Vir Biotechnology","highestDevelopmentStatusID":null,"companyTruncated":"Sanofi \/ V.."},{"orgOrder":0,"company":"BioNTech","sponsor":"Genmab","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Genmab Takes Full Control of Acasunlimab Development Program","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"","productType":"Large 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Find Clinical Drug Pipeline Developments & Deals for Keytruda

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : AMX-818,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Vir Biotechnology

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Details : Through the license agreement, Vir Biotechnology will gain the rights of three clinical-stage masked TCEs, which include SAR446309 (AMX-818) for the treatment of HER2-mutated Breast Neoplasms.

                          Product Name : SAR446309

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 01, 2024

                          Lead Product(s) : AMX-818,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Vir Biotechnology

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Sanofi Company Banner

                          02

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Lead Product(s) : UV1,Pembrolizumab,Sargramostim

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : UV1 is a hTERT inhibitor, which is being evaluated in combination with pembrolizumab in patients for the treatment of metastatic or recurrent head and neck cancer.

                          Product Name : UV1

                          Product Type : Vaccine

                          Upfront Cash : Not Applicable

                          August 05, 2024

                          Lead Product(s) : UV1,Pembrolizumab,Sargramostim

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Lead Product(s) : Eftilagimod Alfa,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : IMP321 (Eftilagimod Alpha) is an APC activator protein, being investigated in combination with pembrolizumab as first-line treatment of recurrent or metastatic head & neck squamous cell carcinoma.

                          Product Name : Efti

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 11, 2024

                          Lead Product(s) : Eftilagimod Alfa,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : Keytruda (Pembrolizumab) is a PD-1 inhibitor antibody, which is currently being evaluated in combination with lenvatinib for the first-line treatment of patients with advanced nccRCC.

                          Product Name : Keytruda

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 27, 2024

                          Lead Product(s) : Pembrolizumab,Lenvatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Merck & Co

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : MDNA11 is a IL-2 beta receptor super-agonist. It is being evaluated in combination with Keytruda for the treatment of solid tumor, renal cell carcinoma & triple negative breast cancer.

                          Product Name : MDNA11

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 26, 2024

                          Lead Product(s) : MDNA11,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : Tivdak (tisotumab vedotin) is an ADC that acts as coagulation factor III binding agent & tubulin inhibitor. It is being evaluated for the treatment of Head and Neck Squamous Cell Carcinoma.

                          Product Name : Tivdak

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 03, 2024

                          Lead Product(s) : Tisotumab Vedotin,Pembrolizumab,Carboplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : STX-001 is a novel programmable self-replicating mRNA encapsulated in lipid nanoparticles (LNPs), being evaluated for THE treatment of advanced solid tumors.

                          Product Name : STX-001

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 30, 2024

                          Lead Product(s) : STX-001,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : Merus will use the proceeds to advance the clinical development of its candidates, including MCLA-158 (petosemtamab), a Biclonics® low-fucose human full-length IgG1 antibody targeting the EGFR.

                          Product Name : MCLA-158

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          May 29, 2024

                          Lead Product(s) : Petosemtamab,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Jefferies

                          Deal Size : $400.2 million

                          Deal Type : Public Offering

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                          09

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Lead Product(s) : Tebentafusp,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Kimmtrak (tebentafusp) is a novel bispecific protein comprised of a soluble T cell receptor fused to an anti-CD3 immune-effector function. It is being investigated for Malignant Melanoma, Cutaneous.

                          Product Name : Kimmtrak

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 29, 2024

                          Lead Product(s) : Tebentafusp,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharmaconex 2024
                          Not Confirmed
                          Pharmaconex 2024
                          Not Confirmed

                          Details : Keytruda (pembrolizumab), anti-PD-1 therapy, met its endpoint, in combination with chemotherapy for the treatment of patients with high-risk early-stage triple-negative breast cancer.

                          Product Name : Keytruda

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 28, 2024

                          Lead Product(s) : Pembrolizumab,Carboplatin,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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