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Applicable"},{"orgOrder":0,"company":"Kiniksa Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Abiprubart","moa":"","graph1":"Immunology","graph2":"Phase I","graph3":"Kiniksa Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Kiniksa Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Kiniksa Pharmaceuticals \/ Not Applicable"}]

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                            01

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Abiprubart

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Kiniksa Begins Enrollment in Abiprubart Phase 2b Trial for Sjogren Disease

                            Details : KPL-404 (abiprubart) is an investigational humanized anti-CD40 monoclonal antibody. Given subcutaneously, it is being evaluated for the treatment of sjogren’s disease.

                            Brand Name : KPL-404

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 09, 2024

                            Lead Product(s) : Abiprubart

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Abiprubart

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Kiniksa Pharmaceuticals Announces Development Indication for Abiprubart

                            Details : KPL-404 (abiprubart) is an investigational humanized anti-CD40 monoclonal antibody designed to inhibit CD40-CD154 (CD40 ligand) interaction. It is being evaluated for Sjogren’s Disease.

                            Brand Name : KPL-404

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 02, 2024

                            Lead Product(s) : Abiprubart

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Genentech

                            Deal Size : $700.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Kiniksa Pharmaceuticals Announces Closing of Global License Agreement with Genentech for Vixarelimab

                            Details : KPL-716 (vixarelimab) is an investigational fully human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammatio...

                            Brand Name : KPL-716

                            Molecule Type : Large molecule

                            Upfront Cash : $100.0 million

                            September 12, 2022

                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Genentech

                            Deal Size : $700.0 million

                            Deal Type : Licensing Agreement

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                            04

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                            Study Phase : Preclinical

                            Sponsor : Genentech

                            Deal Size : $700.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Kiniksa Pharmaceuticals Announces Global License Agreement with Genentech for Vixarelimab

                            Details : Genentech will focus on development of KPL-716 (vixarelimab) in fibrosis, where oncostatin M (OSM)-mediated pathogenesis is thought to be an important pathway for intervention in multiple fibrotic indications.

                            Brand Name : KPL-716

                            Molecule Type : Large molecule

                            Upfront Cash : $100.0 million

                            August 03, 2022

                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                            Highest Development Status : Preclinical

                            Sponsor : Genentech

                            Deal Size : $700.0 million

                            Deal Type : Licensing Agreement

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                            05

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Kiniksa Outlines Next Steps for the Development of Mavrilimumab

                            Details : Ongoing Phase 3 study of mavrilimumab in COVID-19-related ARDS represents the fastest path to potential registration for the asset, and there remains a significant unmet need in these patients.

                            Brand Name : KPL-301

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 08, 2021

                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Rilonacept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Kiniksa Announces FDA Approval of ARCALYST ® (rilonacept) for Recurrent Pericarditis

                            Details : The US FDA has approved Kiniksa Pharmaceuticals’ interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) inhibitor Arcalyst (rilonacept) for the treatment of recurrent pericarditis and reduction in risk of recurrence in adults and children 12 year...

                            Brand Name : Arcalyst

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 18, 2021

                            Lead Product(s) : Rilonacept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Kiniksa Announces Data from U.S. Investigator-Initiated Study of Mavrilimumab in Severe COVID-19 Pneumonia and...

                            Details : Data showed an early signal of efficacy, with trends toward clinical improvement as well as lower mortality and shorter duration of mechanical ventilation in patients treated with mavrilimumab on top of corticosteroids, including dexamethasone, and/or re...

                            Brand Name : KPL-301

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 22, 2020

                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Kiniksa Commences Dosing of Vixarelimab Phase 2b Clinical Trial in Prurigo Nodularis

                            Details : Vixarelimab is a fully-human monoclonal antibody that targets oncostatin M receptor beta. The Phase 2b trial is designed to investigate the efficacy, safety, and pharmacokinetics of vixarelimab in patients with prurigo nodularis.

                            Brand Name : KPL-716

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 15, 2020

                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Kiniksa Pharmaceuticals

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                            Kiniksa Pharmaceuticals

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                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Kiniksa Announces Breakthrough Therapy Designation Granted to Vixarelimab for the Treatment of Pruritus Associ...

                            Details : Kiniksa expects to initiate a Phase 2b clinical trial of vixarelimab in prurigo nodularis, evaluating a range of once-monthly dose regimens, by the end of the year.

                            Brand Name : KPL-716

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 16, 2020

                            Lead Product(s) : Vixarelimab

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Kiniksa Pharmaceuticals

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                            Kiniksa Pharmaceuticals

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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Kiniksa Announces American College of Rheumatology Convergence 2020 Abstracts Presentation of Mavrilimumab Pha...

                            Details : Mavrilimumab was well-tolerated; there were no drug-related serious adverse events, and the rates of drug-related treatment-emergent adverse events between mavrilimumab recipients and placebo recipients were similar.

                            Brand Name : KPL-301

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 09, 2020

                            Lead Product(s) : Mavrilimumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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