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                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Vyjuvek (beremagene geperpavec) is a non-invasive, topical, redosable gene therapy designed to deliver two copies of the COL7A1 gene when applied directly to DEB wounds.

                          Product Name : Vyjuvek

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 28, 2025

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : KB408 is a gene therapy that delivers a copy of the SERPINA1 gene to treat patients with alpha-1 antitrypsin deficiency.

                          Product Name : KB408

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 12, 2024

                          Lead Product(s) : KB408

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Vyjuvek (beremagene geperpavec) is a non-invasive, topical, redosable gene therapy designed to deliver two copies of the COL7A1 gene when applied directly to DEB wounds.

                          Product Name : Vyjuvek

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : KB707 is a modified HSV-1 vector delivering genes for IL-12 and IL-2 to the lung, under development for advanced lung cancer.

                          Product Name : KB707

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          April 22, 2024

                          Lead Product(s) : KB707

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : KB707 is a HSV-1 vector designed to deliver genes encoding IL-12 and IL-2 to the tumor microenvironment to promote systemic immune-mediated tumor clearance. It is being developed for lung cancer.

                          Product Name : KB707

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          February 13, 2024

                          Lead Product(s) : KB707

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Vyjuvek (beremagene geperpavec-svdt) is a non-invasive, topical, redosable gene therapy designed to deliver two copies of the COL7A1 gene when applied directly to DEB wounds.

                          Product Name : B-VEC

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 19, 2023

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Vyjuvek (beremagene geperpavec-svdt) is a non-invasive, topical, redosable gene therapy designed to deliver two copies of the COL7A1 gene when applied directly to DEB wounds.

                          Product Name : B-VEC

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          November 27, 2023

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : KB408 is an inhaled (nebulized) formulation of the Company’s novel replication-defective, non-integrating HSV-1-based vector designed to deliver two copies of the SERPINA1 transgene, that encodes for human alpha-1 antitrypsin protein, for the treatment...

                          Product Name : KB408

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 21, 2023

                          Lead Product(s) : KB408

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : B-VEC (beremagene geperpavec) is an investigational non-invasive, topical, redosable gene therapy designed to deliver two copies of the COL7A1 gene when applied directly to DEB wounds. FDA and EMA have granted B-VEC orphan drug designation for DEB treatm...

                          Product Name : B-VEC

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 01, 2023

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The Company was awarded the PRV following the FDA accelerated approval of Vyjuvek (beremagene geperpavec-svdt), , the first-ever redosable gene therapy, for the treatment of recessive or dominant dystrophic epidermolysis bullosa (DEB) for patients 6 mont...

                          Product Name : B-VEC

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 21, 2023

                          Lead Product(s) : Beremagene Geperpavec

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : $100.0 million

                          Deal Type : Divestment

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