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Find Clinical Drug Pipeline Developments & Deals by Kymera Therapeutics
Under the agreement, NEOsphere will utilize its target & E3-agnostic platform to screen molecular glue compounds on a proteome-wide level, to support Kymera’s robust drug discovery engine.
KT-621 is a once daily, oral STAT6 degrader with a potential biologics-like efficacy profile, to address multiple diseases including atopic dermatitis, asthma, and chronic obstructive pulmonary disorder, among others.
Kymera will use the proceeds to advance its pipeline of preclinical and clinical degrader programs, including SAR444656 (KT-474), a first-in-class IRAK4 degrader, for the treatment of immune-inflammatory diseases, such as hidradenitis suppurativa, atopic dermatitis.
Kymera will use the proceeds to advance its pipeline of preclinical and clinical degrader programs, including SAR444656 (KT-474), a first-in-class IRAK4 degrader, for the treatment of immune-inflammatory diseases, such as hidradenitis suppurativa, atopic dermatitis.
Kymera will use the proceeds to advance its pipeline of preclinical and clinical degrader programs, including SAR444656 (KT-474), a first-in-class IRAK4 degrader, for the treatment of immune-inflammatory diseases, such as hidradenitis suppurativa, atopic dermatitis.
Under the collaboration, Kymera is evaluating KT-474 (SAR444656), a first-in-class, investigational IRAK4 degrader, in the randomized Phase 2 clinical trial for Atopic Dermatitis.
Under the collaboration, Kymera is evaluating KT-474 (SAR444656), a first-in-class, investigational IRAK4 degrader, in the randomized Phase 2 clinical trial in hidradenitis suppurativa.
KT-333 is a highly selective degrader of STAT3 in development for the treatment of multiple STAT3-dependent pathologies, including hematological malignancies and solid tumors.
KT-253 is a novel, highly potent and selective heterobifunctional MDM2 degrader, has superior activity compared to MDM2 SMIs and demonstrated greater than 200-fold improvements in both in vitro oncologic cell growth inhibition and apoptosis.
The expanded partnership comprises 12 targets and grants Kymera exclusive rights to compounds discovered within the collaboration. X-Chem will apply its world-leading DEL platform to support Kymera’s discovery of small molecules and best-in-class protein degraders.