[{"orgOrder":0,"company":"Kymera Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"KT-474","moa":"IRAK4","graph1":"Immunology","graph2":"Preclinical","graph3":"Kymera Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Kymera Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Kymera Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Kymera Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"KTX-201","moa":"STAT3","graph1":"Oncology","graph2":"Preclinical","graph3":"Kymera 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I","graph3":"Kymera Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Kymera Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Kymera Therapeutics \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : KT-621 is oral STAT6 degrader with a potential biologics-like efficacy profile, to address multiple diseases including atopic dermatitis, asthma, COPD & others.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 24, 2024

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : KT-621 is an investigational first-in-class once daily, oral STAT6 degrader. Currently;y, it is being evaluated for treating Atopic Dermatitis and Asthma.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 10, 2024

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The net proceeds will advance the preclinical and clinical degrader programs, including SAR444656 (KT-474) for treating immune-inflammatory diseases like hidradenitis suppurativa & atopic dermatitis.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          September 01, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $275.0 million

                          Deal Type : Public Offering

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                          04

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Phathom intends to use the net proceeds from the offering to fund commercialization expenses and further clinical development of Voquezna (vonoprazan) for the treatment of Erosive GERD.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 21, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $258.7 million

                          Deal Type : Public Offering

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                          05

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Kymera intends to use the net proceeds from the offering to continue advancing its pipeline, which includes SAR444656 (KT-474) being evaluated in the mid-stage for treating atopic dermatitis.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 19, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $225.0 million

                          Deal Type : Public Offering

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                          06

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : SAR444656 (KT-474), a first-in-class IRAK4 degrader, being developed for the treatment of immune-inflammatory diseases, such as hidradenitis suppurativa, atopic dermatitis.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 07, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : KT-621 is a once daily, oral STAT6 degrader with a potential biologics-like efficacy profile, to address multiple diseases including atopic dermatitis, asthma and COPD.

                          Product Name : KT-621

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 03, 2024

                          Lead Product(s) : KT-621

                          Therapeutic Area : Dermatology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Kymera will use proceeds to advance its degrader programs, including SAR444656, a first-in-class IRAK4 degrader, for treating hidradenitis suppurativa and atopic dermatitis.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 01, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $275.0 million

                          Deal Type : Public Offering

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                          09

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Kymera will use proceeds to advance its degrader programs, including SAR444656, a first-in-class IRAK4 degrader, for treating hidradenitis suppurativa and atopic dermatitis.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 01, 2024

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $287.5 million

                          Deal Type : Public Offering

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                          10

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Under the collaboration, Kymera is evaluating KT-474 (SAR444656), a first-in-class, investigational IRAK4 degrader, in the randomized Phase 2 clinical trial in hidradenitis suppurativa.

                          Product Name : KT-474

                          Product Type : Other Small Molecule

                          Upfront Cash : $150.0 million

                          October 27, 2023

                          Lead Product(s) : KT-474

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $2,150.0 million

                          Deal Type : Collaboration

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