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    [{"orgOrder":0,"company":"Lava Therapeutics","sponsor":"J.P. Morgan","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Antibody","year":"2021","type":"Public Offering","leadProduct":"LAVA-051","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Lava Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lava Therapeutics \/ J.P. Morgan","highestDevelopmentStatusID":"6","companyTruncated":"Lava Therapeutics \/ J.P. 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    Find Clinical Drug Pipeline Developments & Deals by Lava Therapeutics

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                            01

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-1266

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Doses First Patient in Phase 1 LAVA-1266 Study in Hematological Cancers

                            Details : LAVA-1266 is a potent bi-specific, T cell engager that targets CD123+ tumor cells. It is being evaluated for the hematologic cancers including acute myeloid leukemia & myelodysplastic syndrome.

                            Product Name : LAVA-1266

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 10, 2025

                            Lead Product(s) : LAVA-1266

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Lava Therapeutics

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                            Lead Product(s) : PF-08046052

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Pfizer Inc

                            Deal Size : $700.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            LAVA Announces Pfizer Milestone for PF-08046052 in Clinical Development

                            Details : Lava will receive milestone payments for SGN-EGFRd2 (PF-08046052), evaluated for colorectal neoplasms and non-small-cell lung carcinoma treatment.

                            Product Name : SGN-EGFRd2

                            Product Type : Other Large Molecule

                            Upfront Cash : $50.0 million

                            May 03, 2024

                            Lead Product(s) : PF-08046052

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Pfizer Inc

                            Deal Size : $700.0 million

                            Deal Type : Agreement

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                            03

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-1207,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            LAVA Announces Collaboration with Merck To Evaluate LAVA-1207 and KEYTRUDA®

                            Details : The collaboration evaluates Merck's KEYTRUDA® (pembrolizumab) with LAVA-1207, targeting PSMA to kill PSMA-positive tumor cells in patients with mCRPC.

                            Product Name : LAVA-1207

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            January 25, 2024

                            Lead Product(s) : LAVA-1207,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Lava Therapeutics

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                            Lava Therapeutics

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                            Lead Product(s) : LAVA-1207

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics to Present LAVA-1207 Clinical Data at the 2023 ASCO GU Symposium

                            Details : LAVA-1207 is a Gammabody™ that conditionally activates Vgamma9 Vdelta2 T cells upon crosslinking to PSMA to trigger the potent and preferential killing of PSMA-positive tumor cells, including metastatic castration-resistant prostate cancer.

                            Product Name : LAVA-1207

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 23, 2023

                            Lead Product(s) : LAVA-1207

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Lava Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : JANSSEN BIOTECH

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            LAVA Therapeutics Announces Selection by Janssen of Lead Gamma-Delta T-Cell Engager Bispecific Antibody to Mov...

                            Details : Under the collaboration, Janssen has chosen a lead gamma-delta T-cell engager bispecific antibody candidate aimed at an undisclosed tumor-associated antigen for further development towards clinical settings for the treatment of cancer.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            January 06, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : JANSSEN BIOTECH

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            06

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics to Present On-Mechanism Pharmacodynamics Data from the Phase 1/2a Clinical Trial of LAVA-051...

                            Details : LAVA-051, is a Gammabody™ that targets CD1d-expressing tumors,uniquely activates both Vγ9Vδ2 T cells as well as invariant natural killer T cells, which represent another conserved immune effector cell population, in a target-dependent manner.

                            Product Name : LAVA-051

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            July 10, 2022

                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics Presents Initial LAVA-051 Clinical Data at the ESMO Targeted Anticancer Therapies Congress 2...

                            Details : LAVA-051, a Gammabody designed to activate both Vgamma9 Vdelta2 T cells and type 1 NKT cells to kill CD1d-expressing tumor cells, preliminary data shows encouraging initial clinical safety; no dose-limiting toxicity or cytokine release syndrome.

                            Product Name : LAVA-051

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            July 03, 2022

                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics Highlights Encouraging Clinical Updates on Lead Program, LAVA-051, in Chronic Lymphocytic Le...

                            Details : LAVA-051 is a humanized Gammabody™ designed to activate both Vγ9Vδ2 (Vgamma9 Vdelta2) T cells and type 1 NKT cells to kill CD1d-expressing tumor cells.

                            Product Name : LAVA-051

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            June 16, 2022

                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics to Present Updated LAVA-051 Clinical Data at the 2022 American Society of Clinical Oncology ...

                            Details : LAVA-051, is a Gammabody that targets CD1d-expressing tumors, demonstrated efficacy and safety in a variety of preclinical models,it uniquely activates both Vγ9Vδ2 T cells as well as iNKT cells, which represent another conserved immune effector cell po...

                            Product Name : LAVA-051

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            April 27, 2022

                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Lava Therapeutics

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                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            LAVA Therapeutics to Present Initial Phase 1/2a Clinical Trial Dose Escalation Data of LAVA-051 in Chronic Lym...

                            Details : The dose-escalation data demonstrated a favorable safety profile to date and early encouraging signs of potential anti-tumor activity of LAVA-051, as well as a desirable PK-PD profile, in patients with chronic lymphocytic leukemia and multiple myeloma.

                            Product Name : LAVA-051

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 06, 2022

                            Lead Product(s) : LAVA-051

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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