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Biotech \/ Not Applicable"},{"orgOrder":0,"company":"Legend Biotech","sponsor":"Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Licensing Agreement","leadProduct":"LB2102","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Legend Biotech","amount2":1.1100000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":1.1100000000000001,"dosageForm":"","sponsorNew":"Legend Biotech \/ Novartis Pharmaceuticals Corporation","highestDevelopmentStatusID":"6","companyTruncated":"Legend Biotech \/ Novartis Pharmaceuticals Corporation"},{"orgOrder":0,"company":"Legend Biotech","sponsor":"Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Licensing 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Corporation","highestDevelopmentStatusID":"12","companyTruncated":"Legend Biotech \/ GenScript Biotech Corporation"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

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                          Details : Carvykti (ciltacabtagene autoleucel) is a FDA approved BCMA-directed genetically modified autologous T cell immunotherapy indicated for the treatment of relapsed/refractory multiple myeloma in adults.

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 27, 2024

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : GenScript Biotech Corporation

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          PharmaVenue
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                          PharmaVenue
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                          Details : Carvykti (ciltacabtagene autoleucel) is an FDA-approved genetically modified autologous T cell immunotherapy that inhibits BCMA. It is administered intravenously for the treatment of r/r MM in adults.

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 02, 2024

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Johnson & Johnson Innovative Medicine

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Carvykti (ciltacabtagene autoleucel) is an FDA-approved, BCMA-directed T cell immunotherapy for treating relapsed or refractory multiple myeloma in adult patients, with promising outcomes.

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 22, 2024

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Johnson & Johnson Innovative Medicine

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Carvykti (ciltacabtagene autoleucel) is a BCMA-targeted T cell therapy for adults with relapsed or refractory multiple myeloma.

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 23, 2024

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Johnson & Johnson Innovative Medicine

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Under agreement, Legend Biotech will conduct a Phase 1 clinical trial for its autologous CAR-T cell therapy candidate, LB2102 in the U.S. Novartis will conduct development for the licensed products.

                          Brand Name : LB2102

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $100.0 million

                          January 03, 2024

                          Lead Product(s) : LB2102

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Novartis Pharmaceuticals Corporation

                          Deal Size : $1,110.0 million

                          Deal Type : Licensing Agreement

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Under the agreement, Legend Biotech will conduct a Phase 1 clinical trial for its autologous CAR-T cell therapy candidate, LB2102 in the U.S. Novartis will conduct all other development for the licensed products.

                          Brand Name : LB2102

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $100.0 million

                          November 13, 2023

                          Lead Product(s) : LB2102

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Novartis Pharmaceuticals Corporation

                          Deal Size : $1,110.0 million

                          Deal Type : Licensing Agreement

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Carvykti (ciltacabtagene autoleucel) is a BCMA-directed, genetically modified autologous T-cell immunotherapy, which involves reprogramming a patient’s own T-cells with a transgene encoding a chimeric antigen receptor that identifie and eliminate cell ...

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 06, 2023

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Carvykti (ciltacabtagene autoleucel) is a BCMA-directed, genetically modified autologous T-cell immunotherapy, which involves reprogramming a patient’s own T-cells with a transgene encoding a chimeric antigen receptor that identifies and eliminates cel...

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 25, 2023

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Carvykti (Ciltacabtagene autoleucel) is a BCMA-directed, genetically modified autologous T-cell immunotherapy, which involves reprogramming a patient’s own T-cells with a transgene encoding a chimeric antigen receptor that identifies and eliminates cel...

                          Brand Name : Carvykti

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          January 02, 2023

                          Lead Product(s) : Ciltacabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : LB2102 is designed to selectively target delta-like ligand 3 (DLL-3), a ligand that is highly restricted to various malignancies, including SCLC, large cell neuroendocrine carcinoma (LCNEC), certain other neuroendocrine tumors and some prostate cancers.

                          Brand Name : LB2102

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 21, 2022

                          Lead Product(s) : LB2102

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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