[{"orgOrder":0,"company":"Pfenex","sponsor":"Serum Institute of India Private Limited","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Agreement","leadProduct":"CRM197","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Pfenex","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Pfenex \/ Serum Institute of India Private Limited","highestDevelopmentStatusID":"10","companyTruncated":"Pfenex \/ Serum Institute of India Private Limited"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"Pandion Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Licensing Agreement","leadProduct":"Antibodies","moa":"","graph1":"Immunology","graph2":"Discovery","graph3":"Ligand 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Pharmaceuticals","sponsor":"Vernalis","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Undisclosed","year":"2020","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Oncology","graph2":"Discovery","graph3":"Ligand Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"2","companyTruncated":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"Pfenex","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"","productType":"Peptide","year":"2020","type":"Not Applicable","leadProduct":"Teriparatide","moa":"PTH 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Pharmaceuticals","highestDevelopmentStatusID":"3","companyTruncated":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"Taurus Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Acquisition","leadProduct":"Mono- and Bispecific human antibodies","moa":"","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Ligand Pharmaceuticals","amount2":0.01,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":0.01,"dosageForm":"","sponsorNew":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"3","companyTruncated":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"Xcella Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large 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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Collaboration","leadProduct":"Sugemalimab","moa":"PD-L1","graph1":"Oncology","graph2":"Phase III","graph3":"Ligand Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"intravenous infusion","sponsorNew":"Ligand Pharmaceuticals \/ CStone Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Ligand Pharmaceuticals \/ CStone Pharmaceuticals"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"GSK","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2020","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Neurology","graph2":"Discovery Platform","graph3":"Ligand Pharmaceuticals","amount2":0.16,"highestDevelopmentShortName":"Discovery 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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Partnership","leadProduct":"Asparaginase Erwinia Chrysanthemi (recombinant)-rywn","moa":"Asparagine synthetase","graph1":"Oncology","graph2":"Approved","graph3":"Ligand Pharmaceuticals","amount2":0.16,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0.16,"dosageForm":"Intramuscular Injection","sponsorNew":"Ligand Pharmaceuticals \/ Jazz Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Ligand Pharmaceuticals \/ Jazz Pharmaceuticals"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2021","type":"Licensing Agreement","leadProduct":"Pneumococcal 15-valent Conjugate Vaccine","moa":"Opsonophagocytosis","graph1":"Infections and Infectious 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Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Ligand Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"Sermonix Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Lasofoxifene","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Ligand Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"Ligand Pharmaceuticals \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"Ligand Pharmaceuticals","sponsor":"OmniAb","pharmaFlowCategory":"D","therapeuticArea":"Technology","country":"","productType":"Large 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Find Clinical Drug Pipeline Developments & Deals by Ligand Pharmaceuticals

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The net proceeds will secure ongoing pipeline progress, including INV501, a first-in-class orally available small molecule that can selectively enhance T cell mediated anti-tumor immune responses.

                          Brand Name : INV501

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 15, 2024

                          Lead Product(s) : INV501

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Invios

                          Deal Size : $8.8 million

                          Deal Type : Series A Financing

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                          02

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Filspari (sparsentan) is a once-daily approved oral medication, designed to selectively target two critical pathways in the disease progression of IgAN (endothelin-1 and angiotensin II).

                          Brand Name : Filspari

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 06, 2024

                          Lead Product(s) : Sparsentan

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved

                          Recipient : Travere Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Ligand acquires Apeiron Biologics pipeline which also includes Qarziba (dinutuximab beta), it is indicated for the treatment of high-risk neuroblastoma in patients aged 12 months and above.

                          Brand Name : Qarziba

                          Molecule Type : Large molecule

                          Upfront Cash : $100.0 million

                          July 08, 2024

                          Lead Product(s) : Dinutuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Apeiron Biologics

                          Deal Size : $128.0 million

                          Deal Type : Acquisition

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                          04

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Financing supports AGEN1181 and AGEN2034 Phase 3 for metastatic colorectal cancer without active liver metastases.

                          Brand Name : AGEN1181

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          May 07, 2024

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Agenus

                          Deal Size : $100.0 million

                          Deal Type : Financing

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                          05

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Zelsuvmi (berdazimer topical gel, 10.3%) is a nitric oxide (NO) releasing agent which is approved for the topical treatment of molluscum contagiosum in adults and pediatric patients one year or older.

                          Brand Name : Zelsuvmi

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 05, 2024

                          Lead Product(s) : Berdazimer Sodium

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The partnership aims to accelerate Phase 3 development of Qtorin™ rapamycin for the treatment of Microcystic Lymphatic Malformations (Microcystic LMs).

                          Brand Name : Qtorin

                          Molecule Type : Small molecule

                          Upfront Cash : $5.0 million

                          December 01, 2023

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Recipient : Palvella Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          07

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Through the acquisition, Ligand acquires royalty on Sanofi’s Tzield (teplizumab-mzwv), the first disease-modifying therapy in type 1 diabetes and a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and children aged 8 years an...

                          Brand Name : Tzield

                          Molecule Type : Large molecule

                          Upfront Cash : $20.0 million

                          November 01, 2023

                          Lead Product(s) : Teplizumab-mzwv

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved

                          Recipient : Tolerance Therapeutics

                          Deal Size : $20.0 million

                          Deal Type : Acquisition

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                          08

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Ligand has acquired a 13 percent portion of the royalties and milestones owed to Ovid related to the potential approval and commercialization of TAK-935 (soticlestat), being developed by Takeda in two Phase 3 trials for Lennox-Gastaut syndrome and Dravet...

                          Brand Name : TAK-935

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 18, 2023

                          Lead Product(s) : Soticlestat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Recipient : Ovid Therapeutics

                          Deal Size : $30.0 million

                          Deal Type : Agreement

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                          09

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Through the acquisition, Ligand will gain access to all the assets of Novan, including SB206 (berdazimer sodium gel), all other programs in development, the NITRICIL™ drug delivery technology, and the commercial assets of its EPI health business.

                          Brand Name : SB206

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 27, 2023

                          Lead Product(s) : Berdazimer Sodium

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Recipient : Novan

                          Deal Size : $15.0 million

                          Deal Type : Divestment

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                          10

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Filspari (sparsentan) is an endothelin and angiotensin II receptor antagonist indicated to reduce proteinuria in adults with IgAN. It is being investigated for focal segmental glomerulosclerosis.

                          Brand Name : Filspari

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 21, 2023

                          Lead Product(s) : Sparsentan

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved

                          Recipient : Travere Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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