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Find Clinical Drug Pipeline Developments & Deals by Linnaeus Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The fund will support the clinical development of its lead compound, LNS8801, which targets a G protein-coupled receptor (GPER), for the treatment of metastatic cutaneous melanoma.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 26, 2025

                          Lead Product(s) : LNS8801

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : National Cancer Institute

                          Deal Size : $2.0 million

                          Deal Type : Funding

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : LNS8801 is an oral specific and potent agonist of GPER whose activity is dependent on the expression of GPER. GPER activation depletes c-Myc protein levels rapidly and durably. LNS8801 displays potent antitumor activities and inducing immune memory.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 19, 2023

                          Lead Product(s) : LNS8801

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : LNS8801 is an orally bioavailable and highly specific and potent agonist of GPER whose activity is dependent on the expression of GPER. In preclinical cancer models, LNS8801 displays potent antitumor activities across a wide range of tumor types.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 21, 2022

                          Lead Product(s) : LNS8801,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The combination of LNS8801 with pembrolizumab has demonstrated strong signals of activity in patients with metastatic cancer who had previously benefited from and then developed secondary resistance to ICI therapy.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 06, 2022

                          Lead Product(s) : LNS8801,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : LNS8801 is an orally bioavailable and highly specific and potent agonist of GPER whose activity is dependent on the expression of GPER. GPER activation by LNS8801 rapidly and durably depletes c-Myc protein levels.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 03, 2021

                          Lead Product(s) : LNS8801,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : For the first time, any company has dosed a patient in a clinical trial specifically targeting the G protein-coupled estrogen receptor, in combination with pembrolizumab. LNS8801 is an orally bioavailable small molecule that is a highly specific and pote...

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 13, 2020

                          Lead Product(s) : LNS8801,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The authors also demonstrated that GPER protein can be detected in a large percentage of clinical specimens, suggesting that GPER may represent a new therapeutic target for PDAC.

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 06, 2020

                          Lead Product(s) : LNS8801

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : U.S. Food and Drug Administration (FDA) has granted Fast Track designation for LNS8801 for the treatment of patients with metastatic or unresectable melanoma who have progressed on or after anti–programmed cell death receptor or ligand (anti–PD-1/L1)...

                          Product Name : LNS8801

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 18, 2020

                          Lead Product(s) : LNS8801

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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