Active Filter(s):
Details:
Linperlisib (YY-20394) is a highly selective and potent PI3Kδ inhibitor that has shown a favorable safety profile, encouraging anti-tumor activities and promising PK and pharmaceutical properties as an oral once-a-day agent in late-stage clinical development.
Lead Product(s): Linperlisib
Therapeutic Area: Oncology Product Name: YY-20394
Highest Development Status: Phase II Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 03, 2022
Details:
The collaborative approach will provide a steady stream of therapeutic candidates, YL-13027, for oncology clinical development, which the MD Anderson team, including David S. Hong, M.D., deputy chair of Investigational Cancer Therapeutics, will investigate.
Lead Product(s): Linperlisib
Therapeutic Area: Oncology Product Name: YY-20394
Highest Development Status: Phase II Product Type: Small molecule
Partner/Sponsor/Collaborator: The University of Texas MD Anderson Cancer Center
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration January 20, 2022
Details:
Linperlisib, a potent oral PI3Kδ inhibitor, had robust clinical activity with 79.5% ORR in relapsed or refractory Follicular Lymphoma. The safety data from the FL Phase 2 study indicated that linperlisib was generally safe and tolerable with manageable adverse events.
Lead Product(s): Linperlisib
Therapeutic Area: Oncology Product Name: YY-20394
Highest Development Status: Phase III Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 11, 2021
Details:
Yingli Pharma will grant Hengrui Medicine joint development rights and exclusive commercialization rights of PI3kδ inhibitor YY-20394 in Greater China.
Lead Product(s): Linperlisib
Therapeutic Area: Oncology Product Name: YY-20394
Highest Development Status: Phase III Product Type: Small molecule
Partner/Sponsor/Collaborator: Jiangsu Hengrui Medicine
Deal Size: $20.0 million Upfront Cash: Undisclosed
Deal Type: Agreement February 08, 2021