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    [{"orgOrder":0,"company":"Ascentage Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"APG-2575","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Ascentage Pharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Ascentage Pharma \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Ascentage Pharma \/ Not Applicable"},{"orgOrder":0,"company":"Ascentage Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"APG-2575","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Ascentage Pharma","amount2":0,"highestDevelopmentShortName":"Ph 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Morgan","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"Lisaftoclax","moa":"||Bcl-2","graph1":"Oncology","graph2":"Phase III","graph3":"Ascentage Pharma","amount2":0.13,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.14000000000000001,"dosageForm":"Oral Tablet","sponsorNew":"Ascentage Pharma \/ J.P. Morgan","highestDevelopmentStatusID":"10","companyTruncated":"Ascentage Pharma \/ J.P. Morgan"},{"orgOrder":0,"company":"Ascentage Pharma","sponsor":"J.P. Morgan","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"Lisaftoclax","moa":"||Bcl-2","graph1":"Oncology","graph2":"Phase III","graph3":"Ascentage Pharma","amount2":0.14000000000000001,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.14000000000000001,"dosageForm":"Oral","sponsorNew":"Ascentage Pharma \/ J.P. Morgan","highestDevelopmentStatusID":"10","companyTruncated":"Ascentage Pharma \/ J.P. Morgan"}]

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                            01

                            Ascentage Pharma

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                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $142.5 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Ascentage Announces Partial Exercise of Underwriters’ Option to Purchase Additional Shares

                            Details : The net proceeds will used to support the company's late-stage product APG-2575 (lisaftoclax) to file NDA/BLA in china. It is being evaluated for the treatment of Chronic Lymphocytic Leukemia.

                            Product Name : APG-2575

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            February 07, 2025

                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $142.5 million

                            Deal Type : Public Offering

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                            02

                            Ascentage Pharma

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                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $126.4 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Ascentage Pharma Announces Closing of U.S. Initial Public Offering

                            Details : The net proceeds will used to support the company's late-stage product APG-2575 (lisaftoclax) to file NDA/BLA in china. It is being evaluated for the treatment of Chronic Lymphocytic Leukemia.

                            Product Name : APG-2575

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 28, 2025

                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $126.4 million

                            Deal Type : Public Offering

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                            03

                            Ascentage Pharma

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                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $126.4 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Ascentage Pharma Announces Pricing of U.S. Initial Public Offering

                            Details : The net proceeds will used to support the company's late-stage product APG-2575 (lisaftoclax) to file NDA/BLA in china. It is being evaluated for the treatment of Chronic Lymphocytic Leukemia.

                            Product Name : APG-2575

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 23, 2025

                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $126.4 million

                            Deal Type : Public Offering

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                            04

                            Ascentage Pharma

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                            The Generic Rx Session
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                            Lead Product(s) : Lisaftoclax,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ascentage Pharma Lisaftoclax NDA Priority Review by China NMPA

                            Details : APG-2575 (lisaftoclax) is a novel, oral small molecule Bcl-2 selective inhibitor being investigated in combination of azacitidine for relapsed or refractory chronic lymphocytic leukemia.

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 17, 2024

                            Lead Product(s) : Lisaftoclax,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Ascentage Pharma

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                            The Generic Rx Session
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                            Ascentage Pharma

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                            The Generic Rx Session
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                            Lead Product(s) : Lisaftoclax,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Lisaftoclax Phase 3 Study Cleared by China CDE for High-Risk Myelodysplastic Syndrome

                            Details : APG-2575 (lisaftoclax) is a novel, orally administered small molecule Bcl-2 selective inhibitor being investigated in combination of azacitidine for higher-risk myelodysplastic syndrome.

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 12, 2024

                            Lead Product(s) : Lisaftoclax,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Ascentage Pharma

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                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Ascentage Pharma and AstraZeneca Enter into Clinical Collaboration on the Registrational Phase III Study of Bc...

                            Details : The two companies will jointly conduct Phase III of the Bcl-2 inhibitor, APG-2575 (lisaftoclax), in combination with AstraZeneca's BTK inhibitor, Calquence (acalabrutinib), in treatment-naive patients with first-line chronic lymphocytic leukemia/small ly...

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 15, 2023

                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Ascentage Pharma

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                            The Generic Rx Session
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                            Ascentage Pharma

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                            The Generic Rx Session
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                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ascentage Pharma Received Clearance from U.S. FDA to Proceed with Global Registrational Phase III Clinical Tri...

                            Details : APG-2575 (lisaftoclax) is a novel, orally administered small molecule Bcl-2 selective inhibitor developed by Ascentage Pharma to treat a range of malignancies by selectively blocking the antiapoptotic protein Bcl-2, thus restoring the normal apoptosis pr...

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 06, 2023

                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Ascentage Pharma

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                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ASH 2022 | Ascentage Pharma to Present Data of Olverembatinib (HQP1351) in Three Oral Reports, Including the F...

                            Details : Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor, selectively binds BCL-2 (Ki < 0.1 nM), disrupts BCL-2:BIM complexes, and compromises mitochondrial outer membrane potential, culminating in BAX/BAK-dependent, caspase-mediated apoptosis.

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 03, 2022

                            Lead Product(s) : Lisaftoclax,Acalabrutinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Ascentage Pharma

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                            The Generic Rx Session
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                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ascentage Pharma Presents Latest Results from Six Preclinical Studies at AACR Annual Meeting 2022

                            Details : Study demonstrated that Alrizomadlin combined with APG-2575 (lisaftoclax) synergistically inhibited the proliferation of RS4:11-BCL-2 mutant cell lines and the growth of cell-derived xenografts in vivo.

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 14, 2022

                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Ascentage Pharma

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                            The Generic Rx Session
                            Not Confirmed

                            Ascentage Pharma

                            China arrow
                            The Generic Rx Session
                            Not Confirmed
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                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Ascentage Pharma Announces First Patient Dosed in China in the Pivotal Phase II Study of Lisaftoclax (APG-2575...

                            Details : APG-2575 (lisaftoclax), a small-molecule Bcl-2 selective inhibitor treat hematologic malignancies and solid tumors by selectively blocking antiapoptotic protein Bcl-2 and hence restoring normal apoptosis process in cancer cells.

                            Product Name : APG-2575

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 14, 2022

                            Lead Product(s) : Lisaftoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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