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    [{"orgOrder":0,"company":"Palladio Zannini Industrie","sponsor":"Samsara BioCapital","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"ITALY","productType":"Small molecule","year":"2020","type":"Series B Financing","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Palladio Zannini Industrie","amount2":0.02,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.02,"dosageForm":"Capsule","sponsorNew":"Palladio Zannini Industrie \/ Samsara BioCapital","highestDevelopmentStatusID":"10","companyTruncated":"Palladio Zannini Industrie \/ Samsara BioCapital"},{"orgOrder":0,"company":"Palladio Biosciences","sponsor":"Centessa Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Palladio Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Palladio Biosciences \/ Centessa Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Palladio Biosciences \/ Centessa Pharmaceuticals"},{"orgOrder":0,"company":"Palladio Biosciences","sponsor":"Centessa Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Palladio Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Palladio Biosciences \/ Centessa Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Palladio Biosciences \/ Centessa Pharmaceuticals"},{"orgOrder":0,"company":"Centessa Pharmaceuticals","sponsor":"General Atlantic","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2021","type":"Series A Financing","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Centessa Pharmaceuticals","amount2":0.25,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.25,"dosageForm":"Capsule","sponsorNew":"Centessa Pharmaceuticals \/ General Atlantic","highestDevelopmentStatusID":"10","companyTruncated":"Centessa Pharmaceuticals \/ General Atlantic"},{"orgOrder":0,"company":"Centessa Pharmaceuticals","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2021","type":"Public Offering","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Centessa Pharmaceuticals","amount2":0.33000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.33000000000000002,"dosageForm":"Capsule","sponsorNew":"Centessa Pharmaceuticals \/ Morgan Stanley","highestDevelopmentStatusID":"10","companyTruncated":"Centessa Pharmaceuticals \/ Morgan Stanley"},{"orgOrder":0,"company":"Centessa Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Centessa Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Centessa Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Centessa Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Centessa Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Lixivaptan","moa":"V2R","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Centessa Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Centessa Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Centessa Pharmaceuticals \/ Not Applicable"}]

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                            01

                            Centessa Pharmaceuticals

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Centessa Pharmaceuticals Makes Strategic Decision to Discontinue Clinical Development of Lixivaptan for Autoso...

                            Details : Decision is based on reassessment of commercial potential of VPA-985 (lixivaptan) as potential best-in-class therapy for patients with ADPKD, following recent observation of alanine aminotransferase and aspartate aminotransferase elevations in ALERT Stud...

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 02, 2022

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Centessa Pharmaceuticals

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Centessa Pharmaceuticals Doses First Subject in a Global Phase 3 ACTION Study of Lixivaptan in Autosomal Domin...

                            Details : The start of dosing in the ACTION Study, designed to serve as a single registration trial and will evaluate the efficacy and safety of VPA-985 (lixivaptan), a nonpeptide selective vasopressin V2 receptor antagonist, in a broad group of ADPKD patients.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 24, 2022

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Centessa Pharmaceuticals

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Morgan Stanley

                            Deal Size : $330.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Centessa Announces Pricing of Initial Public Offering

                            Details : Lixivaptan (VPA-985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 27, 2021

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Morgan Stanley

                            Deal Size : $330.0 million

                            Deal Type : Public Offering

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                            04

                            Centessa Pharmaceuticals

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : General Atlantic

                            Deal Size : $250.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            Centessa Pharmaceuticals Launches with $250 Million Series A Financing and Unveils a New Kind of Pharmaceutica...

                            Details : Centessa Pharmaceuticals portfolio consists of four clinical stage programs, including two that are in late-stage clinical development. Palladio Biosciences, a subsidiary of Centessa, is developing lixivaptan, an oral non-peptide of kidney diseases.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            February 16, 2021

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : General Atlantic

                            Deal Size : $250.0 million

                            Deal Type : Series A Financing

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                            05

                            Palladio Biosciences

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                            Palladio Biosciences

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Centessa Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palladio Biosciences Doses First Patient With Lixivaptan in The ALERT Study

                            Details : The ALERT Study, designed to assess the safety of lixivaptan in autosomal dominant polycystic kidney disease (ADPKD) patients who previously discontinued therapy with tolvaptan due to liver toxicity, is currently recruiting patients in the United States.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 17, 2020

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Centessa Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Palladio Biosciences

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Centessa Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palladio Biosciences Announces Presentation of Data from a Study of Lixivaptan Use in an ADPKD Patient who Pre...

                            Details : The presentation will include the results of more than 12 months of safe treatment with lixivaptan in this study, which was conducted as an expanded access clinical study under an IND.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 20, 2020

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Centessa Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Palladio Zannini Industrie

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                            Palladio Zannini Industrie

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                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Samsara BioCapital

                            Deal Size : $20.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Palladio Completes $20 Million Series B Financing

                            Details : Proceeds from the financing will fund Palladio’s Phase 3 ALERT Study and advance operations.

                            Brand Name : VPA-985

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 25, 2020

                            Lead Product(s) : Lixivaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Samsara BioCapital

                            Deal Size : $20.0 million

                            Deal Type : Series B Financing

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