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Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"LB-100","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Lixte Biotechnology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Lixte Biotechnology \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Lixte Biotechnology \/ Not Applicable"}]

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01

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with atezolizumab for the treatment of colorectal cancer.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

August 26, 2024

Lead Product(s) : LB-100,Atezolizumab

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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02

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with Dostarlimab-gxly for the treatment of ovarian clear cell carcinoma.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

March 21, 2024

Lead Product(s) : LB-100,Dostarlimab

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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03

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : Under the terms of the license agreement, LIXTE will allow LB-100, which is a PP2A inhibitor with Dostarlimab for the treatment of Ovarian Clear Cell Carcinoma.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Undisclosed

February 26, 2024

Lead Product(s) : LB-100,Dostarlimab

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : National Institute of Neurological Disorders and Stroke

Deal Size : Undisclosed

Deal Type : Licensing Agreement

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04

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with Dostarlimab-gxly for the treatment of ovarian clear cell carcinoma.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

January 29, 2024

Lead Product(s) : LB-100,Dostarlimab

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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05

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : The expanded collaboration aims to study drug synergies of LIXTE’s lead clinical compound, LB-100, an inhibitor of the PP2A phosphatase, with immunotherapy in various cancers.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Undisclosed

October 16, 2023

Lead Product(s) : LB-100,Atezolizumab

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Netherlands Cancer Institute

Deal Size : Undisclosed

Deal Type : Expanded Collaboration

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06

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is an inhibitor of PP2A, added to dostarlimab significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for Clear-Cell Ovarian Cancer.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

September 20, 2023

Lead Product(s) : LB-100,Dostarlimab

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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07

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : The company intends to use the net proceeds for further clinical development of its first-in-class lead clinical PP2A inhibitor, LB-100, being developed in patients with low and intermediate-1 risk Myelodysplastic Syndrome (MDS).

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Undisclosed

July 20, 2023

Lead Product(s) : LB-100

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Alliance Global Partners

Deal Size : $3.5 million

Deal Type : Public Offering

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08

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is an inhibitor of PP2A, added to doxorubicin significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for advanced soft tissue sarcoma.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

June 07, 2023

Lead Product(s) : LB-100,Doxorubicin Hydrochloride

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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09

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LB-100 is an inhibitor of PP2A, added to doxorubicin significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for advanced soft tissue sarcoma.

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

April 24, 2023

Lead Product(s) : LB-100,Doxorubicin Hydrochloride

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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10

BePharma
Not Confirmed
BePharma
Not Confirmed

Details : LIXTE’s first-in-class protein phosphatase 2A (PP2A) inhibitor LB-100 with a standard regimen for previously untreated, extensive stage disease small cell lung cancer (ED-SCLC).

Product Name : LB-100

Product Type : Small molecule

Upfront Cash : Not Applicable

April 04, 2023

Lead Product(s) : LB-100,Atezolizumab,Carboplatin

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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