24
ALL24
Lixte BiotechnologyYear
24
ALL4
20248
20235
20225
20212
2020DEALS // DEV.
24
ALL7
Deals17
DevelopmentsCountry
24
ALL24
U.S.A24
ALL1
Alliance Global Partners3
City of Hope1
Foundation for Angelman Syndrome Therapeutics1
National Institute of Neurological Disorders and Stroke2
Netherlands Cancer Institute14
Not Applicable2
WestPark CapitalTherapeutic Area
24
ALL2
Genetic Disease22
OncologyStudy Phase
24
ALL4
Phase II7
Phase I/ Phase II7
Phase I6
PreclinicalDeal Type
7
ALL1
Agreement1
Collaboration1
Expanded Collaboration1
Licensing Agreement3
Public OfferingProduct Type
24
ALL24
Small moleculeDosage Form
19
ALL12
Infusion7
Intravenous InfusionLead Product
24
ALL24
LB-100Target
11
ALL9
PP2A2
Protein phosphataseLead Product(s) : LB-100,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
First Patient Dosed in LIXTE’s LB-100 Colorectal Cancer Trial with NKI Collaboration
Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with atezolizumab for the treatment of colorectal cancer.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
August 26, 2024
Lead Product(s) : LB-100,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
LIXTE Updates Progress with LB-100 as a PP2A Inhibitor to Enhance Cancer Treatments
Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with Dostarlimab-gxly for the treatment of ovarian clear cell carcinoma.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
March 21, 2024
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : National Institute of Neurological Disorders and Stroke
Deal Size : Undisclosed
Deal Type : Licensing Agreement
LIXTE Biotechnology Enters Exclusive Patent License Agreement with NINDS and NCI
Details : Under the terms of the license agreement, LIXTE will allow LB-100, which is a PP2A inhibitor with Dostarlimab for the treatment of Ovarian Clear Cell Carcinoma.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Undisclosed
February 26, 2024
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : National Institute of Neurological Disorders and Stroke
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
First Patient Dosed with LIXTE's LB-100 and GSK's Dostarlimab-gxly in Ovarian Cancer Trial
Details : LB-100 is a PP2A inhibitor which is being evaluated in phase 1/2 clinical trials in combination with Dostarlimab-gxly for the treatment of ovarian clear cell carcinoma.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
January 29, 2024
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Netherlands Cancer Institute
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
LIXTE, Netherlands Cancer Institute, and Oncode Institute to Expand Collaboration
Details : The expanded collaboration aims to study drug synergies of LIXTE’s lead clinical compound, LB-100, an inhibitor of the PP2A phosphatase, with immunotherapy in various cancers.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Undisclosed
October 16, 2023
Lead Product(s) : LB-100,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Netherlands Cancer Institute
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LB-100 is an inhibitor of PP2A, added to dostarlimab significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for Clear-Cell Ovarian Cancer.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
September 20, 2023
Lead Product(s) : LB-100,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Alliance Global Partners
Deal Size : $3.5 million
Deal Type : Public Offering
Details : The company intends to use the net proceeds for further clinical development of its first-in-class lead clinical PP2A inhibitor, LB-100, being developed in patients with low and intermediate-1 risk Myelodysplastic Syndrome (MDS).
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Undisclosed
July 20, 2023
Lead Product(s) : LB-100
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Alliance Global Partners
Deal Size : $3.5 million
Deal Type : Public Offering
Lead Product(s) : LB-100,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LB-100 is an inhibitor of PP2A, added to doxorubicin significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for advanced soft tissue sarcoma.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
June 07, 2023
Lead Product(s) : LB-100,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LB-100 is an inhibitor of PP2A, added to doxorubicin significantly increase the effectiveness of PD-1 immune-checkpoint blockade by activating cytotoxic T cells and CAR-T cells. It is being investegated for advanced soft tissue sarcoma.
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
April 24, 2023
Lead Product(s) : LB-100,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LB-100,Atezolizumab,Carboplatin
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LIXTE’s first-in-class protein phosphatase 2A (PP2A) inhibitor LB-100 with a standard regimen for previously untreated, extensive stage disease small cell lung cancer (ED-SCLC).
Product Name : LB-100
Product Type : Small molecule
Upfront Cash : Not Applicable
April 04, 2023
Lead Product(s) : LB-100,Atezolizumab,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable