Iovance’s Clinical Hold Lifted by FDA for IOV-LUN-202 in NSCLC
Details : LN-145 is a ready-to-infuse TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for patients with metastatic NSCLC.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 04, 2024
Lead Product(s) : LN-145,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LN-145 TIL therapy for patients who have progressed on or after chemotherapy and anti-PD-1 therapy for advanced (unresectable or metastatic) NSCLC without EGFR, ROS or ALK genomic mutations
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
July 10, 2023
Lead Product(s) : LN-145,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TIL product candidate, LN-145 for metastatic melanoma, has the potential to become the first approved one-time cell therapy for a solid tumor cancer. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 08, 2022
Details : The first Iovance clinical study participant infused with LN-145, a TIL cell therapy manufactured at iCTC is enrolled in a metastatic non-small cell lung cancer (mNSCLC) cohort in the IOV-COM-202 basket study in solid tumors.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
September 23, 2021
Details : This phase II trial studies how well autologous tumor infiltrating lymphocytes LN-145 works in treating patients with ovarian cancer, anaplastic thyroid cancer, osteosarcoma, or other bone and soft tissue sarcomas that do not respond to treatment.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 29, 2021
Lead Product(s) : LN-145,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Company presented new interim clinical data for the tumor infiltrating lymphocyte therapy LN-145 in combination with pembrolizumab in advanced, recurrent, or metastatic head and neck squamous cell carcinoma who are immune checkpoint inhibitor naive.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 09, 2020
Lead Product(s) : LN-145,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LN-145,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Safety and efficacy of tumor infiltrating lymphocytes (TIL; LN-145) in combination with pembrolizumab for advanced, recurrent or metastatic HNSCC, will be discussed in the at Society for Immunotherapy of Cancer (SITC) 35th Annual Meeting.
Brand Name : LN-145
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 14, 2020
Lead Product(s) : LN-145,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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