Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Eflornithine & Lomustine Combination Shows Survival Benefit in Astrocytoma IDH Mutant
Details : A combination of an ODC inhibitor, eflornithine and cancer DNA inhibitor lomustine is being investigated in patients with grade 3 IDH mutant astrocytoma.
Product Name : DFMO
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 22, 2024
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Fibromun,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : University Hospital Zürich
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : L19TNF is a fully-human immunomodulatory product consisting of the L19 antibody and TNF. The L19 antibody is specific to the EDB domain of fibronectin and mediates selective localization of TNF to the site of disease while sparing healthy organs.
Product Name : L19TNF
Product Type : Protein
Upfront Cash : Inapplicable
May 24, 2023
Lead Product(s) : Fibromun,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : University Hospital Zürich
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Panobinostat lactate,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Biodexa Completes Recruitment of Cohort A in Study of MTX110 in Patients with Recurrent Glioblastoma
Details : MTX110 (panobinostat) is a hydroxamic acid and acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor), which is investigated for the treatment of patients with recurrent glioblastoma (rGBM).
Product Name : MTX110
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 10, 2023
Lead Product(s) : Panobinostat lactate,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Panobinostat lactate,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MTX110 is a water-soluble form of panobinostat free base, achieved through complexation with hydroxypropyl-β-cyclodextrin (HPBCD), that enables convection-enhanced delivery (CED) at potentially chemotherapeutic doses directly to the site of the tumour.
Product Name : MTX110
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 14, 2022
Lead Product(s) : Panobinostat lactate,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Orbus Therapeutics’ Phase 3 Eflornithine STELLAR Study Reaches Full Patient Enrollment
Details : Enrollment of patients in Phase 3 STELLAR trial for DFMO (eflornithine hydrochloride), a novel cytostatic agent that irreversibly inhibits ornithine decarboxylase in patients in patients with recurrent anaplastic astrocytoma.
Product Name : DFMO
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 19, 2022
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Orbus Therapeutics Granted European Patent for Method of Use for Eflornithine
Details : Eflornithine is a novel cytostatic agent that irreversibly inhibits ornithine decarboxylase, a key enzyme in mammalian polyamine biosynthesis that is up-regulated in certain types of cancer.
Product Name : DFMO
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
September 28, 2021
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Orbus Therapeutics Receives U.S. Patent for Eflornithine Formulations
Details : Patent relates to a solution of eflornithine for oral administration currently being evaluated in Orbus’ Phase 3 STELLAR study in rare brain cancer.
Product Name : DFMO
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 23, 2020
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Longitude Capital
Deal Size : $71.0 million
Deal Type : Series A Financing
Details : The expanded Series A funding will support the ongoing STELLAR study, a Phase 3 clinical trial studying eflornithine in patients with anaplastic astrocytoma whose cancer has recurred following radiation and adjuvant chemotherapy.
Product Name : DFMO
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
October 22, 2020
Lead Product(s) : Eflornithine Hydrochloride,Lomustine
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Longitude Capital
Deal Size : $71.0 million
Deal Type : Series A Financing