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    [{"orgOrder":0,"company":"Fulcrum Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Losmapimod","moa":"MAPK\/p38-alpha","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Fulcrum Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral","sponsorNew":"Fulcrum Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Fulcrum Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Fulcrum Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Losmapimod","moa":"MAPK\/p38-alpha","graph1":"Infections and 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Fulcrum Therapeutics \/ Sanofi","highestDevelopmentStatusID":"10","companyTruncated":"Fulcrum Therapeutics \/ Sanofi"}]

    Find Clinical Drug Pipeline Developments & Deals for Losmapimod

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                            01

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : Sanofi

                            Deal Size : $1,055.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Fulcrum and Sanofi Collaborate On Losmapimod for Muscular Dystrophy

                            Details : Sanofi receives exclusive rights to commercialize FTX-1821 (losmapimod), an oral small molecule being investigated for facioscapulohumeral muscular dystrophy (FSHD), in all territories outside the US.

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : $80.0 million

                            May 13, 2024

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : Sanofi

                            Deal Size : $1,055.0 million

                            Deal Type : Collaboration

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                            02

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Announces Completion of Enrollment in the Phase 3 REACH Clinical Trial of Losmapimod in Facioscapulohu...

                            Details : FTX-1821 (losmapimod) is a small molecule, which is act as selective p38alpha/beta mitogen activated protein kinase (MAPK) inhibitor, which is investigated for the treatment of facioscapulohumeral muscular dystrophy.

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 09, 2023

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : FSHD Society

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Advocacy and Industry Partners Launch New Global Coalition to Speed Delivery of New Therapies for Facioscapulo...

                            Details : The collaboration aims for the development of FTX-1821 (losmapimod), an investigational small molecule inhibitor of p38α/β Mitogen Activated Protein Kinase (MAPK), for the treatment of facioscapulohumeral muscular dystrophy (FSHD).

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 20, 2023

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : FSHD Society

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Fulcrum Therapeutics

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                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics Announces Pricing of Upsized Public Offering of Common Stock

                            Details : Fulcrum Therapeutics intends to use the net proceeds for the development of FTX-1821 (losmapimod), a small molecule, for the treatment of facioscapulohumeral muscular dystrophy (FSHD).

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 17, 2023

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

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                            05

                            Fulcrum Therapeutics

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                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics to Present New Data from the Open Label Extension of Phase 2 ReDUX4 Study at the World Mu...

                            Details : Results reported from the ReDUX4 trial demonstrated slowed disease progression and improved function, including positive impacts on upper extremity strength, supporting Losmapimod’s (FTX-1821) potential to be a transformative therapy for the treatment ...

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 10, 2022

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics Enrolls First Patient in Pivotal Global Phase 3 Clinical Trial of Losmapimod for Faciosca...

                            Details : Losmapimod is an oral small molecule that selectively inhibit p38α/β mitogen activated protein kinase (MAPK) has the potential to be the first therapy to treat FSHD, the second most common form of muscular dystrophy.

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 07, 2022

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics® Announces REACH, a Phase 3 Clinical Trial of Losmapimod in Facioscapulohumeral Muscular...

                            Details : Results from Phase 2b clinical trial demonstrated that losmapimod, an investigational, selective p38α/β mitogen-activated protein kinase inhibitor, slowed disease progression and improved function in people with FSHD. Based on these data company initia...

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 03, 2022

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics Announces Multiple Presentations on FSHD at the American Academy of Neurology's Annual Me...

                            Details : Losmapimod is an investigational, selective p38α/β mitogen activated protein kinase (MAPK) inhibitor, that demonstrates potential to slow or stop disease progression in facioscapulohumeral muscular dystrophy from its clinical data.

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 04, 2022

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum Therapeutics Announces Results from ReDUX4 Trial with Losmapimod in Facioscapulohumeral Muscular Dystr...

                            Details : Losmapimod showed statistically significant* and clinically relevant benefit across multiple structural, functional and patient reported endpoints. Losmapimod was well tolerated with no treatment related discontinuations or treatment related serious adve...

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 24, 2021

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Fulcrum Therapeutics

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                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Fulcrum’s losmapimod Fails Interim Analysis in Muscle Wasting Trial

                            Details : Results from the interim analysis in the first 29 randomized subjects indicate that DUX4-driven gene expression did not show a separation from placebo at 16 weeks.

                            Product Name : FTX-1821

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 08, 2020

                            Lead Product(s) : Losmapimod

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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