Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lysogene Provides Updates and Topline Results from Phase 2/3 AAVance Gene Therapy Clinical Study
Details : LYS-SAF302 (olenasufligene relduparvovec) is a novel gene therapy in Phase 2/3 development for the treatment of MPS IIIA, or Sanfilippo syndrome type A. LYS-SAF302 delivers a functional copy of the human SGSH gene directly to brain cells using the AAV ca...
Brand Name : LYS-SAF302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 18, 2022
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : LYS-SAF302 (olenasufligene relduparvovec) delivers a working copy of the human SGSH gene directly to the brain through intra-cerebral injection. Mutations to the SGSH gene are responsible for the developmental, physical and behavioral symptoms of the dis...
Brand Name : LYS-SAF302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 18, 2022
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Preliminary results evaluating LYS-SAF302 (olenasufligene relduparvovec) in patients with Sanfilippo syndrome type A who have been followed for at least two years demonstrated improvement, stabilization, or slowing down of decline in cognitive-developmen...
Brand Name : LYS-SAF302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 18, 2022
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : FXS01
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lysogene Publishes Positive Preliminary Preclinical Results in the Treatment of Fragile X Syndrome
Details : The publication of a peer-reviewed article for FXS01 in EMBO Molecular Medicine showing that adeno-associated viral (AAV) vector-delivered diacylglycerol kinase (DGKk) achieves long-term rescue of fragile X syndrome (FXS) in a mouse model of disease.
Brand Name : FXS01
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 21, 2022
Lead Product(s) : FXS01
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AAVance trial evaluates, effectiveness of a one-time intracerebral delivery of a recombinant adeno-associated virus vector rh.10 carrying the N-sulfoglucosamine sulfohydrolase gene LYS-SAF302 (olenasufligene relduparvovec) in children with MPS IIIA.
Brand Name : LYS-SAF302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 24, 2022
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AAVrh.10 Expressing Beta-galactosidase
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lysogene Provides Medical Update
Details : Lysogene has dosed the first patient in France with LYS-GM101 investigational gene therapy at the Armand Trousseau Hospital (AP-HP). This is the third patient treated with LYS-GM101 in the global adaptative-design clinical trial in children with GM1 gang...
Brand Name : LYS-GM101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 07, 2022
Lead Product(s) : AAVrh.10 Expressing Beta-galactosidase
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase II/ Phase III
Recipient : Sarepta Therapeutics
Deal Size : Undisclosed
Deal Type : Termination
Details : The termination of the agreement will enable Lysogene to regain development and commercialization rights for LYS-SAF302 in the US and other non-EU territories as well as the responsibility for global commercial supply of LYS-SAF302.
Brand Name : LYS-SAF302
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
January 13, 2022
Lead Product(s) : Olenasufligene Relduparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II/ Phase III
Recipient : Sarepta Therapeutics
Deal Size : Undisclosed
Deal Type : Termination
Lead Product(s) : AAVrh.10 Expressing beta-galactosidase
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
UK MHRA Awards Innovation Passport to Lysogene’s Gene Therapy, LYS-GM101 to Treat GM1 Gangliosidosis
Details : LYS-GM101 investigational gene therapy an ‘Innovation Passport’ for the treatment of GM1 gangliosidosis under the United Kingdom’s (UK) Innovative Licensing and Access Pathway (ILAP). LYS-GM101 is currently in clinical development.
Brand Name : LYS-GM101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 20, 2021
Lead Product(s) : AAVrh.10 Expressing beta-galactosidase
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : LYS-GM101
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Bpifrance
Deal Size : Undisclosed
Deal Type : Financing
Lysogene Secures a €4.3 Million Non-dilutive Financing From Bpifrance to Support Its Development
Details : This financing will support the clinical study of LYS-GM101 drug candidate for the treatment of GM1 gangliosidosis and the preclinical studies of LYS-FXS01 in Fragile X syndrome.
Brand Name : LYS-GM101
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
November 26, 2021
Lead Product(s) : LYS-GM101
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Bpifrance
Deal Size : Undisclosed
Deal Type : Financing
Lead Product(s) : AAVrh.10 Expressing Beta-galactosidase
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lysogene Begins Patient Dosing in US Trial of LYS-GM101 to Treat GM1 Gangliosidosis
Details : LYS-GM101 (‘adeno-associated viral vector serotype rh.10 expressing beta-galactosidase’) received orphan drug designation for the treatment of GM1 gangliosidosis in the European Union and in the US in 2017, as well as the Rare Pediatric Disease desig...
Brand Name : LYS-GM101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
August 31, 2021
Lead Product(s) : AAVrh.10 Expressing Beta-galactosidase
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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