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Find Clinical Drug Pipeline Developments & Deals by M6P Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : M011 is a novel recombinant human β-glucosidase (rhGCase) enzyme co-expressed with S1S3 PTase that produces rhGCase with a high M6P levels, resulting in high levels of bis-phosphorylated glycans and high binding affinity for the CI-MPR.

                          Product Name : M011

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          November 02, 2022

                          Lead Product(s) : M011

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Evidence that M041, phosphorylated alpha-N-acetylglucosaminidase, has improved trafficking and binding to M6P receptors. M041 has markedly improved cellular uptake in patient fibroblasts when compared to wild type alpha-N-acetylglucosaminidase.

                          Product Name : M041

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          February 02, 2022

                          Lead Product(s) : M041

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : M011, a highly phosphorylated recombinant β-glucosidase (GCase) enzyme with a high affinity for the cation independent mannose 6-phosphate receptor, demonstrated superiority to imiglucerase, in terms of binding to the CI-MPR and uptake by Gaucher patien...

                          Product Name : M011

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          November 02, 2021

                          Lead Product(s) : M011

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : As the study suggests, M6PT’s M041 recombinant enzyme therapy (NAGLUM6P) employs an efficient and well-trafficked lysosomal enzyme as the key to developing a potentially effective therapy to treat this rare pediatric disorder.

                          Product Name : M041

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          July 28, 2021

                          Lead Product(s) : M041

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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