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Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Acalabrutinib","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ Not Applicable"},{"orgOrder":0,"company":"ImmunityBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"CD19 t-haNK","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"ImmunityBio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"ImmunityBio \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"ImmunityBio \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals for MabThera

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Ituxredi (rituximab) is an anti-CD20 monoclonal antibody, which is indicated for the treatment of non-hodgkin’s lymphoma, chronic lymphocytic leukemia & rheumatoid arthritis.

                          Brand Name : Ituxredi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 29, 2024

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Dr Reddy Company Banner

                          02

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Immunology

                          Study Phase : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : DRL_RI is being developed as a biosimilar of Rituxan/MabThera (rituximab), a CD20 directed cytolytic antibody for various indications including treatment of adult patients with rheumatoid arthritis, non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, ...

                          Brand Name : DRL_RI

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 12, 2023

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Dr Reddy Company Banner

                          03

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : DRL_RI is being developed as a biosimilar of rituximab, CD20 directed cytolytic antibody for various indications including treatment of adult patients with rheumatoid arthritis, non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, pemphigus vulgaris et...

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 19, 2023

                          Lead Product(s) : Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Dr Reddy Company Banner

                          04

                          Details : Updates are based on more than five years of Phase 3 iNNOVATE final analysis data, which demonstrated IMBRUVICA plus rituximab significantly prolonged progression-free survival (PFS) versus rituximab alone in adults with WM.

                          Brand Name : Imbruvica

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 23, 2020

                          Lead Product(s) : Ibrutinib,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          05

                          Details : Phase 3 MURANO trial shows median progression-free survival of 53.6 months in previously treated CLL patients taking VENCLEXTA/VENCLYXTO in combination with rituximab Vs. 17.0 months in patients taking bendamustine plus rituximab after three years or mor...

                          Brand Name : Venclexta

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 05, 2020

                          Lead Product(s) : Venetoclax,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          06

                          Details : Submission is based on results of more than five years of follow-up data from the Phase 3 iNNOVATE clinical trial evaluating IMBRUVICA in combination with rituximab for patients with WM. This is the longest follow-up data available for a BTK inhibitor in...

                          Brand Name : Imbruvica

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 23, 2020

                          Lead Product(s) : Ibrutinib,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          07

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : CD19 t-haNK is a human, allogeneic, NK cell line that has been engineered to express a CAR targeting CD19, which is being evaluated for the treatment of refractory/ relapsed non-hodgkin lymphoma.

                          Brand Name : CD19 t-haNK

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 24, 2024

                          Lead Product(s) : CD19 t-haNK,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.

                          Brand Name : Calquence

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 03, 2024

                          Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : PTG-007, an autologous Treg treatment, resulted in clinical remission for up to 12 years in patients with type-1 diabetes (T1D) in combination with a standard anti-CD20 treatment (rituximab).

                          Brand Name : PTG-007

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 09, 2024

                          Lead Product(s) : PTG-007,Rituximab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Monjuvi (tafasitamab) is a humanized Fc-modified cytolytic CD19-targeting antibody, which is being evaluated in combination with lenalidomide & rituximab for the treatment of R/R follicular lymphoma.

                          Brand Name : Monjuvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 15, 2024

                          Lead Product(s) : Tafasitamab,Rituximab,Lenalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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