Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Madrigal Completes Resmetirom Trial Enrollment in Compensated NASH/MASH Cirrhosis
Details : Rezdiffra (resmetirom) is a once-daily, oral THR-β agonist designed to target key underlying causes of NASH. It is being studied in compensated patients with NASH cirrhosis.
Brand Name : Rezdiffra
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 21, 2024
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Approved
Sponsor : Goldman Sachs & Co. LLC
Deal Size : $600.0 million
Deal Type : Public Offering
Madrigal Pharmaceuticals Announces Pricing of Upsized $600 Million Public Offering
Details : Madrigal plans to use net proceeds for commercial activities related to launching Rezdiffra (resmetirom), a liver-directed THR-β agonist for treating NASH in the U.S.
Brand Name : Rezdiffra
Molecule Type : Small molecule
Upfront Cash : Undisclosed
March 18, 2024
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Approved
Sponsor : Goldman Sachs & Co. LLC
Deal Size : $600.0 million
Deal Type : Public Offering
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Madrigal's Rezdiffra Approved by FDA for NASH with Liver Fibrosis
Details : Rezdiffra (resmetirom) is a once-daily oral THR-β agonist approved for treating noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis.
Brand Name : Rezdiffra
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 14, 2024
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Madrigal Pharmaceuticals Announces EMA Validation of Resmetirom Application for NASH
Details : MGL-3196 (Resmetirom) is a once-daily, oral, liver-directed THR-β agonist , which is being evaluated for the treatment of NASH/MASH with Liver Fibrosis.
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 05, 2024
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Goldman Sachs & Co. LLC
Deal Size : $500.0 million
Deal Type : Public Offering
Madrigal Pharmaceuticals Announces Pricing of $500 Million Public Offering
Details : Madrigal will use the proceeds for its clinical and commercial activities in preparation for a potential launch of MGL-3196 (resmetirom), a once daily, oral, thyroid hormone receptor-beta selective agonist designed to target key underlying causes of NASH...
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Undisclosed
September 28, 2023
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Goldman Sachs & Co. LLC
Deal Size : $500.0 million
Deal Type : Public Offering
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MGL-3196 (resmetirom) is a once daily, oral, thyroid hormone receptor (THR)-beta selective agonist designed to target key underlying causes of NASH in the liver.
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 13, 2023
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MGL-3196 (resmetirom), is a once daily, oral, liver-directed selective thyroid hormone receptor (THR)-β selective agonist designed to target key underlying causes of NASH in the liver.
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 17, 2023
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MGL-3196 (resmetirom), is a once daily, oral, liver-directed selective thyroid hormone receptor (THR)-β selective agonist designed to target key underlying causes of NASH in the liver.
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 18, 2023
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MGL-3196 (resmetirom), is a once daily, oral, liver-directed selective thyroid hormone receptor (THR)-β selective agonist designed to target key underlying causes of NASH in the liver.
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 06, 2023
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : Phase III
Sponsor : Hercules Credit Facility
Deal Size : $255.0 million
Deal Type : Financing
Madrigal Pharmaceuticals Announces $300+ Million in Financing Events to Advance Resmetirom Program
Details : MGL-3196 (resmetirom) is a liver-directed, orally active, selective thyroid hormone receptor-β agonist designed to improve NASH by increasing hepatic fat metabolism and reducing lipotoxicity. We aimed to assess the safety and efficacy of resmetirom in p...
Brand Name : MGL-3196
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 21, 2022
Lead Product(s) : Resmetirom
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : Phase III
Sponsor : Hercules Credit Facility
Deal Size : $255.0 million
Deal Type : Financing
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