Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Dianthus Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Magenta Therapeutics and Dianthus Therapeutics Announce Merger Agreement
Details : The combined company will focus on advancing Dianthus’ pipeline of next-generation complement inhibitors, including DNTH103, an investigational long-acting classical complement pathway inhibitor, currently in a Phase 1 trial to treat people with severe...
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Undisclosed
March 05, 2023
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Dianthus Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Details : MGTA-117 is a targeted conditioning product candidate designed to bind and deplete CD117-expressing target cells in the blood and/or bone marrow prior to a patient undergoing stem cell transplant or receiving an ex vivo gene therapy product.
Product Name : MGTA-117
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
January 25, 2023
Magenta Therapeutics Provides Update for MGTA-117 Phase 1/2 Dose Escalation Clinical Trial
Details : MGTA-117 is Magenta’s most advanced targeted conditioning product candidate designed to deplete CD117-expressing target cells in the blood and/or bone marrow prior to a patient undergoing stem cell transplant or receiving an ex vivo gene therapy produc...
Product Name : MGTA-117
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
December 20, 2022
Details : MGTA-117 is Magenta’s most advanced targeted conditioning product candidate designed to deplete CD117-expressing target cells in the blood and/or bone marrow prior to a patient undergoing stem cell transplant or receiving an ex vivo gene therapy produc...
Product Name : MGTA-117
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
December 12, 2022
Lead Product(s) : MGTA-117
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Magenta Therapeutics Focuses R&D and Operational Spending, Reduces Workforce and Extends Cash Runway
Details : MGTA-117, an anti-human CD117(c-kit)- targeted antibody conjugated to amanitin, an RNA polymerase II inhibitor, and engineered for a short half-life to enable rapid ADC clearance prior to HSCT.
Product Name : MGTA-117
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
April 14, 2022
Lead Product(s) : MGTA-117
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Bluebird Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Magenta Therapeutics to Present Data at the 2022 American Society of Hematology (ASH) Annual Meeting
Details : Magenta is developing MGTA-145, in combination with plerixafor, to improve the process by which stem cells are stimulated out of the bone marrow and into the bloodstream, known as stem cell mobilization. The mobilized cells are then collected and availab...
Product Name : MGTA-145
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
March 11, 2022
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Bluebird Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MGTA-145 is being developed in combination with plerixafor to harness complementary chemokine mechanisms to mobilize hematopoietic stem cells for collection and transplantation.
Product Name : MGTA-145
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
December 05, 2021
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MGTA-145 first-line mobilization program to move into Phase 2 studies in autologous and allogeneic patients in 2020, including allogeneic study in newly announced collaboration with National Marrow Donor Program® (NMDP)/Be The Match®.
Product Name : MGTA-145
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
November 06, 2020
Lead Product(s) : MGTA-145
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MGTA-145 is being developed in combination with plerixafor to harness complementary chemokine mechanisms to mobilize hematopoietic stem cells for collection and transplantation.
Product Name : MGTA-145
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
July 12, 2020
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MGTA-145 was shown to be a rapid, reliable, efficient and G-CSF-free method to obtain high numbers of functional HSCs in a Phase 1 trial; the cells could be gene modified and engraft in animals. MGTA-145 could be used to improve collection and gene thera...
Product Name : MGTA-145
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 14, 2020
Lead Product(s) : MGTA-145,Plerixafor
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable