Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
MannKind Receives PMDA Clearance for Phase 3 Trial of Clofazimine in NTM Lung Disease
Details : MNKD-101 (clofazimine) is active against both slowly growing and rapidly growing mycobacteria and most Gram-positive bacteria in vitro, being developed for pulmonary nontuberculous mycobacteria.
Brand Name : MNKD-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 18, 2024
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Dihydroergotamine Mesylate
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Pulmatrix
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Pulmatrix Announces Cross License Agreement and Transfer of Laboratory to MannKind
Details : MannKind will grant Pulmatrix a royalty free, exclusive license to use MannKind's Cricket inhalation device for the inhaled delivery of PUR3100, a proprietary formulation of dihydroergotamine.
Brand Name : PUR3100
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 30, 2024
Lead Product(s) : Dihydroergotamine Mesylate
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Pulmatrix
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
MannKind Receives Fast Track Designation for Clofazimine Inhalation for NTM Lung Disease
Details : MNKD-101 (clofazimine) has antimicrobial and anti-inflammatory effects, active against mycobacteria and Gram-positive bacteria, and is being developed for pulmonary nontuberculous mycobacteria.
Brand Name : MNKD-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 06, 2024
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Nintedanib Esylate
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
MannKind Proceeds with Phase 1 Nintedanib Dpi Study for Pulmonary Fibrotic Diseases
Details : The inhaled therapeutic candidate MNKD-201 (nintedanib) is being evaluated in early-stage clinical trial studies for treating patients suffering from pulmonary fibrotic diseases.
Brand Name : MNKD-201
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 30, 2024
Lead Product(s) : Nintedanib Esylate
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
MannKind Announces IND Clearance for Phase 3 Study of Clofazimine Inhalation
Details : MNKD-101 (clofazimine) has antimicrobial and anti-inflammatory effects, active against mycobacteria and Gram-positive bacteria, and is being developed for pulmonary nontuberculous mycobacteria.
Brand Name : MNKD-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 29, 2024
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Technosphere Insulin,Degludec
Therapeutic Area : Endocrinology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
MannKind Completes Enrollment Goal for INHALE-1 Pediatric Diabetes Trial with Afrezza®
Details : Afrezza (technosphere insulin) is a USFDA approved insulin receptor agonist which is being evaluated for the treatment of type 1 or type 2 diabetes in pediatric patients.
Brand Name : Afrezza
Molecule Type : Peptide
Upfront Cash : Not Applicable
February 15, 2024
Lead Product(s) : Technosphere Insulin,Degludec
Therapeutic Area : Endocrinology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Treprostinil Sodium
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Recipient : Sagard Healthcare
Deal Size : $200.0 million
Deal Type : Agreement
MannKind and Sagard Enter Into Royalty Purchase Agreement for up to $200 Million
Details : Under the agreement, Sagard will receive royalties of Tyvaso DPI, inhalation powder indicated for pulmonary hypertension associated with interstitial lung disease.
Brand Name : Tyvaso DPI
Molecule Type : Small molecule
Upfront Cash : Undisclosed
January 02, 2024
Lead Product(s) : Treprostinil Sodium
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Recipient : Sagard Healthcare
Deal Size : $200.0 million
Deal Type : Agreement
Lead Product(s) : Insulin Lispro
Therapeutic Area : Endocrinology
Study Phase : Phase IV
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Afrezza (human Insulin) is the only ultra rapid-acting inhaled insulin that act as Insulin receptor agonist, which is investigated in combination with insulin degludec for the treatment of type 1 diabetes.
Brand Name : Afrezza
Molecule Type : Peptide
Upfront Cash : Not Applicable
November 06, 2023
Lead Product(s) : Insulin Lispro
Therapeutic Area : Endocrinology
Highest Development Status : Phase IV
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Insulin Lispro
Therapeutic Area : Endocrinology
Study Phase : Phase IV
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Afrezza (human insulin) is the only ultra rapid-acting inhaled insulin that act as Insulin receptor agonist and works as starts lowering blood sugars in ~12 minutes for adults living with type 1 or type 2 diabetes.
Brand Name : Afrezza
Molecule Type : Peptide
Upfront Cash : Not Applicable
June 22, 2023
Lead Product(s) : Insulin Lispro
Therapeutic Area : Endocrinology
Highest Development Status : Phase IV
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MNKD-101 (clofazimine) possesses antimicrobial and anti-inflammatory properties. It is active against both slowly growing and rapidly growing mycobacteria and most Gram-positive bacteria in vitro. It is currently being developemnt for pulmonary nontuberc...
Brand Name : MNKD-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 23, 2023
Lead Product(s) : Clofazimine
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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