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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Mateon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Mateon Therapeutics \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals by Mateon Therapeutics

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01

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Not Confirmed
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Not Confirmed

Details : Teon Therapeutics has entered into the clinical trial collaboration agreement with Merck for expansion clinical study and will evaluate Teon’s oral, immune response modifier, TT-816, in combination with Merck’s KEYTRUDA (pembrolizumab), for patients ...

Product Name : TT-816

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

January 18, 2023

Lead Product(s) : TT-816,Pembrolizumab

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Merck & Co

Deal Size : Undisclosed

Deal Type : Collaboration

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02

AAN
Not Confirmed
AAN
Not Confirmed

Details : TT-816 is a first-in-class, oral cannabinoid CB2 receptor antagonist acting as an immune checkpoint inhibitor for the treatment of a broad range of solid tumors and is highly selective for the CB2 receptor versus the CB1 receptor.

Product Name : TT-816

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 11, 2022

Lead Product(s) : TT-816,Undisclosed

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

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Not Confirmed
AAN
Not Confirmed

Details : Mateon has completed the enrollment of its sentinel Part 1 and Part 2 COVID-19 patients which allows for the continuing expansion to the targeted 18 patients in part 1 and 18 patients in part 2. OT-101 is an antisense against the host TGF-β protein.

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

August 03, 2021

Lead Product(s) : Trabedersen,Artemisinin

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : Phase II

Sponsor : Oncotelic Therapeutics

Deal Size : Inapplicable

Deal Type : Inapplicable

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04

AAN
Not Confirmed
AAN
Not Confirmed

Details : The funds will be used to advance the company’s lead A2BR-selective antagonist TT-702 into the clinic as well as to build the company’s pipeline.

Product Name : TT-702

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

February 23, 2021

Lead Product(s) : TT-702

Therapeutic Area : Oncology

Highest Development Status : IND Enabling

Sponsor : Oceanpine Capital

Deal Size : $30.0 million

Deal Type : Series A Financing

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05

AAN
Not Confirmed
AAN
Not Confirmed

Details : C-001 is a Phase 2 randomized, placebo-control study to evaluate safety and efficacy of OT-101 in combination with standard of care on two patient cohorts – 1) mild or moderate disease, and 2) severe disease requiring mechanical ventilation or intubati...

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

December 30, 2020

Lead Product(s) : Trabedersen,Undisclosed

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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06

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Not Confirmed
AAN
Not Confirmed

Details : OT-101 has demonstrated robust efficacy against pancreatic cancer, glioblastoma, and melanoma during phase 2 clinical trials. The demonstration that OT-101 will synergize with IL-2 further demonstrate its utility as adjunct to other immunotherapies.

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Undisclosed

October 06, 2020

Lead Product(s) : Trabedersen,Aldesleukin

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Autotelic Bio

Deal Size : Undisclosed

Deal Type : Licensing Agreement

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07

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Not Confirmed
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Not Confirmed

Details : OXi4503 in combination with standard chemotherapy drug cytarabine was generally well tolerated by adult AML patients and a maximum tolerated dose level of OXi4503 was identified as the recommended dose for further clinical development of this novel two-d...

Product Name : OXi4503

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

September 16, 2020

Lead Product(s) : Combretastatin A1 Diphosphate

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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08

AAN
Not Confirmed
AAN
Not Confirmed

Details : GMP and Mateon are working to ensure safety and efficacy of OT-101 and Artemisinin for COVID-19 patients. OT-101 is an antisense against host TGF-β protein required for viral replication.

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

June 22, 2020

Lead Product(s) : Trabedersen

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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09

AAN
Not Confirmed
AAN
Not Confirmed

Details : Mateon has delivered the requisite testing results to Golden Mountain Partners (GMP) confirming the applicability and potential use of OT-101 for the treatment of COVID-19.

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

June 04, 2020

Lead Product(s) : Trabedersen

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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10

AAN
Not Confirmed
AAN
Not Confirmed

Details : The proposed randomized, double-blind, placebo-controlled Phase 2 study is intended to evaluate the safety and efficacy of OT-101 in adult patients hospitalized with COVID-19 and pneumonia in the US.

Product Name : OT-101

Product Type : Oligonucleotide

Upfront Cash : Inapplicable

April 27, 2020

Lead Product(s) : Trabedersen

Therapeutic Area : Infections and Infectious Diseases

Highest Development Status : IND Enabling

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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