12
ALL12
Mateon TherapeuticsYear
12
ALL1
20231
20222
20218
2020DEALS // DEV.
12
ALL3
Deals9
DevelopmentsCountry
12
ALL12
U.S.A12
ALL1
Autotelic Bio8
Inapplicable1
Merck & Co1
Oceanpine Capital1
Oncotelic TherapeuticsTherapeutic Area
12
ALL6
Infections and Infectious Diseases6
OncologyStudy Phase
12
ALL7
Phase II2
Phase I/ Phase II1
Phase I1
IND Enabling1
PreclinicalDeal Type
12
ALL1
Collaboration9
Inapplicable1
Licensing Agreement1
Series A FinancingProduct Type
12
ALL8
Oligonucleotide4
Other Small MoleculeDosage Form
12
ALL1
Intratumoral Infusion6
Intravenous Infusion2
Oral3
UndisclosedLead Product
12
ALL1
Combretastatin A1 Diphosphate1
Pembrolizumab1
TT-7021
TT-8168
TrabedersenTarget
12
ALL1
A2BR2
CB2 receptor8
TGF-beta-21
Tubulin polymerisationLead Product(s) : TT-816,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Teon Therapeutics has entered into the clinical trial collaboration agreement with Merck for expansion clinical study and will evaluate Teon’s oral, immune response modifier, TT-816, in combination with Merck’s KEYTRUDA (pembrolizumab), for patients ...
Product Name : TT-816
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
January 18, 2023
Lead Product(s) : TT-816,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : TT-816,Undisclosed
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TT-816 is a first-in-class, oral cannabinoid CB2 receptor antagonist acting as an immune checkpoint inhibitor for the treatment of a broad range of solid tumors and is highly selective for the CB2 receptor versus the CB1 receptor.
Product Name : TT-816
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 11, 2022
Lead Product(s) : TT-816,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Trabedersen,Artemisinin
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Oncotelic Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Mateon’s Update on C001 - Global Study for Ot-101 Against Covid-19
Details : Mateon has completed the enrollment of its sentinel Part 1 and Part 2 COVID-19 patients which allows for the continuing expansion to the targeted 18 patients in part 1 and 18 patients in part 2. OT-101 is an antisense against the host TGF-β protein.
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
August 03, 2021
Lead Product(s) : Trabedersen,Artemisinin
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Oncotelic Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : TT-702
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Oceanpine Capital
Deal Size : $30.0 million
Deal Type : Series A Financing
Teon Therapeutics Completes $30 Million Series A Financing
Details : The funds will be used to advance the company’s lead A2BR-selective antagonist TT-702 into the clinic as well as to build the company’s pipeline.
Product Name : TT-702
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 23, 2021
Lead Product(s) : TT-702
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Oceanpine Capital
Deal Size : $30.0 million
Deal Type : Series A Financing
Lead Product(s) : Trabedersen,Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : C-001 is a Phase 2 randomized, placebo-control study to evaluate safety and efficacy of OT-101 in combination with standard of care on two patient cohorts – 1) mild or moderate disease, and 2) severe disease requiring mechanical ventilation or intubati...
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
December 30, 2020
Lead Product(s) : Trabedersen,Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Trabedersen,Aldesleukin
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Autotelic Bio
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Details : OT-101 has demonstrated robust efficacy against pancreatic cancer, glioblastoma, and melanoma during phase 2 clinical trials. The demonstration that OT-101 will synergize with IL-2 further demonstrate its utility as adjunct to other immunotherapies.
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
October 06, 2020
Lead Product(s) : Trabedersen,Aldesleukin
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Autotelic Bio
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : Combretastatin A1 Diphosphate
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Granted Pediatric Disease Designation for OXi-4503
Details : OXi4503 in combination with standard chemotherapy drug cytarabine was generally well tolerated by adult AML patients and a maximum tolerated dose level of OXi4503 was identified as the recommended dose for further clinical development of this novel two-d...
Product Name : OXi4503
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
September 16, 2020
Lead Product(s) : Combretastatin A1 Diphosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Mateon and GMP to Proceed to Clinical Development of OT-101 and Artemisin
Details : GMP and Mateon are working to ensure safety and efficacy of OT-101 and Artemisinin for COVID-19 patients. OT-101 is an antisense against host TGF-β protein required for viral replication.
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
June 22, 2020
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Mateon has delivered the requisite testing results to Golden Mountain Partners (GMP) confirming the applicability and potential use of OT-101 for the treatment of COVID-19.
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
June 04, 2020
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The proposed randomized, double-blind, placebo-controlled Phase 2 study is intended to evaluate the safety and efficacy of OT-101 in adult patients hospitalized with COVID-19 and pneumonia in the US.
Product Name : OT-101
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
April 27, 2020
Lead Product(s) : Trabedersen
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable