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    [{"orgOrder":0,"company":"Maze Therapeutics","sponsor":"Matrix Capital Management","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Financing","leadProduct":"MZE001","moa":"GYS1","graph1":"Rare Diseases and Disorders","graph2":"Phase I","graph3":"Maze Therapeutics","amount2":0.19,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Rare Diseases","amount2New":0.19,"dosageForm":"","sponsorNew":"Maze Therapeutics \/ Matrix Capital Management","highestDevelopmentStatusID":"6","companyTruncated":"Maze Therapeutics \/ Matrix Capital Management"},{"orgOrder":0,"company":"Maze Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"MZE001","moa":"GYS1","graph1":"Rare Diseases and Disorders","graph2":"Phase I","graph3":"Maze 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Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Maze Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Maze Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Maze Therapeutics","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Licensing Agreement","leadProduct":"MZE001","moa":"","graph1":"Rare Diseases and Disorders","graph2":"Phase I","graph3":"Maze Therapeutics","amount2":0.75,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Rare Diseases","amount2New":0.75,"dosageForm":"","sponsorNew":"Maze Therapeutics \/ Sanofi","highestDevelopmentStatusID":"6","companyTruncated":"Maze Therapeutics \/ Sanofi"},{"orgOrder":0,"company":"Maze Therapeutics","sponsor":"Shionogi","pharmaFlowCategory":"D","therapeuticArea":"Rare Diseases and Disorders","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Licensing 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Morgan"},{"orgOrder":0,"company":"Maze Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"MZE829","moa":"APOL1","graph1":"Nephrology","graph2":"Phase II","graph3":"Maze Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Maze Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Maze Therapeutics \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Maze Therapeutics

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                            01

                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Maze Doses First Patient in Phase 2 HORIZON Trial for APOL1 Kidney Disease

                            Details : MZE829 is an oral, small molecule inhibitor of APOL1, which is currently being evaluated for the treatment of APOL1 kidney disease.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 07, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $140.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Maze Therapeutics Announces Pricing of Upsized Initial Public Offering

                            Details : The proceeds from the offering will used to fund the clinical development of company's lead product MZE829, which is being evaluated for the treatment of APOL1-mediated kidney disease.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 30, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $140.0 million

                            Deal Type : Public Offering

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                            03

                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Maze Charts Path Through Clinical Development with Planned IPO

                            Details : The proceeds will be used to fund the clinical development of MZE829, an oral APOL1 inhibitor, MZE782, an oral SCL6A19 inhibitor, and other discovery and preclinical programs.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 08, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            04

                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Frazier Life Sciences

                            Deal Size : $115.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Maze Raises $115M Financing to Advance Clinical Programs and Future Pipeline

                            Details : The financing aims to advance the clinical development of company lead programs, which includes MZE829, it is being evaluated for the treatment of APOL1 kidney disease.

                            Product Name : MZE829

                            Product Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 03, 2024

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Frazier Life Sciences

                            Deal Size : $115.0 million

                            Deal Type : Financing

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                            05

                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Maze Positive Phase 1 Data Shows Potential for MZE829 in Kidney Disease

                            Details : MZE829 is an oral, small molecule inhibitor of APOL1, which is currently being evaluated for the treatment of APOL1 kidney disease.

                            Product Name : MZE829

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 25, 2024

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : MZE782

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Maze Therapeutics Initiates Phase 1 Trial Evaluating MZE782 For Chronic Kidney Disease

                            Details : MZE782 is a potentially first-in-class, oral, small molecule targeting the solute transporter, SLC6A19. It is being evaluated for the treatment chronic kidney disease.

                            Product Name : MZE782

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 01, 2024

                            Lead Product(s) : MZE782

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Maze Therapeutics

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                            Lead Product(s) : MZE001

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I

                            Sponsor : Shionogi

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Shionogi and Maze Announce License Agreement for MZE001 for Pompe Disease

                            Details : Shionogi's MZE001, a GYS1 inhibitor, aims to reduce glycogen buildup in Pompe disease by limiting glycogen production.

                            Product Name : MZE001

                            Product Type : Small molecule

                            Upfront Cash : $150.0 million

                            May 10, 2024

                            Lead Product(s) : MZE001

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I

                            Sponsor : Shionogi

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Maze Therapeutics

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                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Sanofi

                            Deal Size : $750.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Maze Therapeutics Announces Exclusive Worldwide License Agreement with Sanofi for MZE001, an Oral Substrate Re...

                            Details : The licensing agreement provides Sanofi with Maze’s glycogen synthase 1 (GYS1) program, including clinical candidate MZE001, an oral GYS1 inhibitor, which is currently in development for the treatment of Pompe disease and other potential indications.

                            Product Name : MZE001

                            Product Type : Small molecule

                            Upfront Cash : $150.0 million

                            May 01, 2023

                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Sanofi

                            Deal Size : $750.0 million

                            Deal Type : Licensing Agreement

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                            09

                            Maze Therapeutics

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                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Maze Therapeutics Announces New Clinical Data Supporting MZE001 as a Potential Treatment for Pompe Disease

                            Details : MZE001 is an oral GYS1 inhibitor that aims to address Pompe disease by limiting disease-causing glycogen buildup. It is currently being evaluated for the potential oral treatment of patients with Pompe disease and potentially other glycogen storage disor...

                            Product Name : MZE001

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 22, 2023

                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Maze Therapeutics

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                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Maze Therapeutics Announces Positive Phase 1 Results from First-in-Human Trial Evaluating MZE001 as a Potentia...

                            Details : MZE001 is an oral GYS1 inhibitor that aims to address Pompe disease by limiting disease-causing glycogen buildup. It is currently being evaluated for the potential oral treatment of patients with Pompe disease and potentially other glycogen storage disor...

                            Product Name : MZE001

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 27, 2023

                            Lead Product(s) : MZE001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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