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    [{"orgOrder":0,"company":"Medigene","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"GERMANY","productType":"Vaccine","year":"2020","type":"Not Applicable","leadProduct":"Autologous dendritic cell vaccine","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Medigene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intradermal Injection","sponsorNew":"Medigene \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Medigene \/ Not Applicable"},{"orgOrder":0,"company":"Medigene","sponsor":"Medigene","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CANADA","productType":"Undisclosed","year":"2020","type":"Collaboration","leadProduct":"Undisclosed","moa":"T Cell 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                            Lead Product(s) : MDG1015

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Medigene Gets FDA Clearance for MDG1015, a TCR-T Therapy for Solid Tumors

                            Details : MDG1015 is a first-in-class, TCR-T therapy targeting NY-ESO-1/ LAGE-1a. It is being developed for gastric cancer, ovarian cancer, myxoid/round cell liposarcoma and synovial sarcoma.

                            Brand Name : MDG1015

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 05, 2024

                            Lead Product(s) : MDG1015

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Gene-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : WuXi Biologics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Medigene and WuXi Biologics Collaborate on Off-the-Shelf TCR-Guided T Cell Engagers

                            Details : The collaboration combines the respective expertise of each company with Medigene’s 3S TCR generation and WuXi Biologics’ unique anti-CD3 mAb for the treatment of cancers.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            August 08, 2024

                            Lead Product(s) : Gene-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : WuXi Biologics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Lead Product(s) : MDG2021,PD1-41BB

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Medigene Announces Lead Selection for KRAS-targeting TCR-T in Solid Tumors

                            Details : MDG2021, a TCR-T therapy targeting KRASG12D with HLA-A*11 being developed in combination with the Company’s PD1-41BB costimulatory switch protein, for solid tumors.

                            Brand Name : MDG2021

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            June 20, 2024

                            Lead Product(s) : MDG2021,PD1-41BB

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : T-cell Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Sponsor : BioNTech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Medigene-BioNTech Collaboration Agreement Extended Beyond Initial Term

                            Details : The collaboration aims to advance T cell receptor immunotherapies against cancer

                            Brand Name : T-cell Therapy

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            May 21, 2024

                            Lead Product(s) : T-cell Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Sponsor : BioNTech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Lead Product(s) : MDG1015

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Medigene Selects Indication for 3rd Generation TCR-T Therapy in Solid Tumors

                            Details : MDG1015, a TCR-T therapy targeting NY-ESO-1/LAGE-1a, is in trials for gastric, ovarian cancers, and soft tissue sarcomas.

                            Brand Name : MDG1015

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 12, 2024

                            Lead Product(s) : MDG1015

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : MDG1015,PD1-41BB

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : AGC Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            AGC Biologics Signs TCR-T Cell Services Agreement to Support Medigene’s New Cell Therapy Product

                            Details : Under the agreement, AGC Biologics is providing autologous production for MDG1015, a third generation TCR-T therapy, focused on the treatment of solid cancers, supporting Medigene’s IND filing and clinical trials.

                            Brand Name : MDG1015

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 25, 2023

                            Lead Product(s) : MDG1015,PD1-41BB

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : AGC Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            Lead Product(s) : MDG2011

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Medigene AG Announces Lead Selection for MDG2011 Representing the First TCR-T Therapy of its KRAS Library

                            Details : MDG2011, a T cell receptor engineered T cell (TCR-T) therapy targeting KRAS (Kirsten rat sarcoma viral oncogene homologue) G12V with HLA-A*11 and being developed in combination with the Company’s PD1-41BB costimulatory switch protein (CSP) technology.

                            Brand Name : MDG2011

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 18, 2023

                            Lead Product(s) : MDG2011

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Medigene

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                            Lead Product(s) : TCR-T-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Medigene AG Expands Patent Portfolio for its End-to-End Platform

                            Details : The patent issued by the Japan Patent Office protecting its PD1-41BB switch receptor. Medigene's PD1-41BB costimulatory switch receptor technology was developed by its partner Helmholtz Munich and is exclusively licensed to Medigene.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 22, 2023

                            Lead Product(s) : TCR-T-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Medigene

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                            Lead Product(s) : TCR-T-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Recipient : Helmholtz Zentrum München

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Medigene Acquires Worldwide, Exclusive License Of CD40L-CD28 Costimulatory Switch Receptor

                            Details : Under the agreement, Medigene accelerates the expansion of its end-to-end platform of multiple, combinable, exclusive and proprietary technologies with the potential to create best-in-class T cell receptor engineered T cell (TCR-T) therapies for patients...

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            May 02, 2023

                            Lead Product(s) : TCR-T-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Recipient : Helmholtz Zentrum München

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            Lead Product(s) : T cell-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Medigene Enters Cooperative Research and Development Agreement with the National Cancer Institute

                            Details : The companies will collaborate to evaluate the potential of Medigene’s proprietary T cell receptors (TCRs) to be used in new cell constructs for the treatment of solid tumors in T cell-based Therapy.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 03, 2023

                            Lead Product(s) : T cell-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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