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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : EscharEx is a bioactive, multimodal debridement therapy for the treatment of chronic and other hard-to-heal wounds, currently in the advanced stages of clinical development for the venous leg ulcers.

                          Product Name : EscharEx

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Bromelain Enriched Proteolytic Enzyme

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : EscharEx is a bioactive, multimodal debridement therapy for the treatment of chronic and other hard-to-heal wounds, currently in the advanced stages of clinical development for the venous leg ulcers.

                          Product Name : EscharEx

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          October 10, 2024

                          Lead Product(s) : Bromelain Enriched Proteolytic Enzyme

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : NexoBrid (anacaulase-bcdb) is a topically administered biological product for enzymatically removing nonviable burn tissue, being studied in phase 3 trials for partial and full-thickness burns.

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          September 01, 2024

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : NexoBrid (anacaulase-bcdb) is a topical biological product that enzymatically removes nonviable burn tissue, approved for treating patients with deep partial- and/or full-thickness thermal burns.

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          August 15, 2024

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The funding will significantly advance the Company’s EscharEx (bromelain enriched proteolytic enzyme) development program for patients with diabetic foot ulcers.

                          Product Name : EscharEx

                          Product Type : Enzyme

                          Upfront Cash : Undisclosed

                          July 16, 2024

                          Lead Product(s) : Bromelain Enriched Proteolytic Enzyme

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : EIC Accelerator

                          Deal Size : $16.2 million

                          Deal Type : Funding

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                          06

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The net proceeds to advance EscharEx (bromelain enriched proteolytic enzyme) pre-commercial activities & expedite the development for the treatment of patients with diabetic foot ulcers.

                          Product Name : EscharEx

                          Product Type : Enzyme

                          Upfront Cash : Undisclosed

                          July 15, 2024

                          Lead Product(s) : Bromelain Enriched Proteolytic Enzyme

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Molnlycke Health Care

                          Deal Size : $25.0 million

                          Deal Type : Private Placement

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                          07

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : NexoBrid (anacaulase-bcdb) is a topically administered biological product that enzymatically removes nonviable burn tissue, approved the treatment of severe burns.

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 08, 2024

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : NexoBrid (anacaulase-bcdb) is a topically administered biological product that enzymatically removes nonviable burn tissue, or eschar, in patients with deep partial and full-thickness thermal burns.

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          November 13, 2023

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : MW005, our topical enzymatic therapy for the treatment of non-melanoma skin cancers received positive initial data from the Company’s U.S. Phase I/II study of MW005 for the treatment of low-risk basal cell carcinoma (BCC).

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          October 07, 2023

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The funding will be used to develop NexoBrid (anacaulase-bcdb), a topically administered biological product that enzymatically removes nonviable burn tissue, as a non-surgical solution for field-care burn treatment for the U.S. Army.

                          Product Name : NexoBrid

                          Product Type : Enzyme

                          Upfront Cash : Undisclosed

                          September 26, 2023

                          Lead Product(s) : Bromelain

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Approved FDF

                          Sponsor : US Department of Defense

                          Deal Size : Undisclosed

                          Deal Type : Funding

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