Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : ME-344,Bevacizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
MEI Pharma Reports Initial Data On ME-344 Combined with Bevacizumab in Colorectal Cancer
Details : ME-344, a novel inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), is being tested with bevacizumab in patients with relapsed metastatic colorectal cancer.
Product Name : ME-344
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 04, 2024
Lead Product(s) : ME-344,Bevacizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Voruciclib,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
MEI Pharma Updates Study Of Oral CDK9 Inhibitor Voruciclib with Venetoclax
Details : ME-522 (voruciclib), a selective CDK9 inhibitor, is being evaluated with venetoclax for the treatment of relapsed and refractory acute myeloid leukemia.
Product Name : ME-522
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 26, 2024
Lead Product(s) : Voruciclib,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ME-344,Bevacizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-344 is a novel mitochondrial inhibitor targeting energy production through the OXPHOS pathway evaluating in combination with bevacizumab in patients with previously treated metastatic colorectal cancer.
Product Name : ME-344
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 16, 2023
Lead Product(s) : ME-344,Bevacizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Voruciclib,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-522 (voruciclib) is an orally administered cyclin-dependent kinase 9 (“CDK9”) inhibitor with potential to treat Alone and in Combination with Venetoclax in Patients with Acute Myeloid Leukemia or B-Cell Malignancies
Product Name : ME-522
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 23, 2023
Lead Product(s) : Voruciclib,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Clinical and preclinical data suggest that ME-401 (zandelisib) distinct characteristics include prolonged target binding, preferential cellular accumulation, high volume of distribution throughout body tissues, and an approx, 28-hour half-life suitable f...
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 05, 2022
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-401 (zandelisib), an orally administered investigational phosphatidylinositol 3- kinase delta ("PI3Kδ") inhibitor in clinical development for the treatment of B-cell malignancies
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 06, 2022
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib,Ibrutinib
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data from preclinical studies with ME-401 (zandelisib), a selective PI3Kδ inhibitor, ex vivo in normal human T cells and in vivo in a murine CLL model suggest that zandelisib has immunomodulatory properties on human T cells.
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 04, 2022
Lead Product(s) : Zandelisib,Ibrutinib
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-401 (zandelisib), an oral and selective inhibitor of PI3K delta, is being evaluated in multiple clinical studies, including COASTAL and TIDAL study, in patients with follicular and marginal zone lymphomas and other B-cell malignancies.
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 03, 2022
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-401 (zandelisib), a selective PI3Kδ inhibitor, is an investigational cancer treatment being developed as an oral, once-daily, potential therapeutic option for patients with B-cell malignancies.
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 18, 2022
Lead Product(s) : Zandelisib,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zandelisib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ME-401 (Zandelisib), an oral and selective inhibitor of PI3Kδ, is being evaluated in multiple clinical studies, including COASTAL, a Phase 3 study, and TIDAL, a Phase 2 study, in patients with relapsed and refractory follicular and marginal zone lymphom...
Product Name : ME-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 26, 2022
Lead Product(s) : Zandelisib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Kyowa Kirin
Deal Size : Inapplicable
Deal Type : Inapplicable