Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Hologen AI commits $430M to MeiraGTx Parkinson's gene therapy
Details : The collaboration aims to advance the clinical development of AAV-GAD, which is being evaluated in the mid-stage clinical trial studies for the treatment of Parkinson’s disease.
Product Name : AAV-GAD
Product Type : Cell and Gene therapy
Upfront Cash : $200.0 million
March 17, 2025
Lead Product(s) : AAV-GAD
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
MeiraGTx Gene Therapy Improves Motor Function in Phase 2 Parkinson’s Trial
Details : AAV-GAD is a gene therapy for Parkinson's disease. It delivers the glutamic acid decarboxylase (GAD) gene to the subthalamic nucleus, to increase production of the inhibitory neurotransmitter GABA.
Product Name : AAV-GAD
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
October 15, 2024
Lead Product(s) : AAV-GAD
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : $415.0 million
Deal Type : Agreement
Details : Under the agreement, Janssen gains the remaining interests in investigational gene therapy AAV5-RPGR (botaretigene sparoparvovec) for the treatment of X-linked retinitis pigmentosa.
Product Name : AAV2/5-RPGR
Product Type : Cell and Gene therapy
Upfront Cash : $350.0 million
December 21, 2023
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : $415.0 million
Deal Type : Agreement
Lead Product(s) : AAV-AQP1
Therapeutic Area : Dental and Oral Health
Study Phase : Phase I/ Phase II
Sponsor : Sanofi
Deal Size : $30.0 million
Deal Type : Financing
Details : Sanofi will receive a right of first negotiation for the use of MeiraGTx’s Riboswitch gene regulation technology for certain Immunology and Inflammation and CNS targets, including AAV-AQP1, a gene therapy for xerostomia caused by Sjogren's syndrome.
Product Name : AAV-AQP1
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
October 30, 2023
Lead Product(s) : AAV-AQP1
Therapeutic Area : Dental and Oral Health
Highest Development Status : Phase I/ Phase II
Sponsor : Sanofi
Deal Size : $30.0 million
Deal Type : Financing
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Treatment with botaretigene sparoparvovec was found to have an acceptable safety profile and efficacy assessments in this proof-of-concept study demonstrated improvements in retinal sensitivity, visual function and functional vision.
Product Name : AAV2/5-RPGR
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
January 10, 2022
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Ongoing Phase 1/2 MGT009 clinical trial demonstrated AAV-RPGR was generally well tolerated and produced significant improvement in vision, including improvement in retinal sensitivity and vision-guided mobility, in the dose escalation phase of the trial.
Product Name : AAV2/5-RPGR
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
October 28, 2020
Lead Product(s) : Botaretigene Sparoparvovec
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable