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molecule","year":"2024","type":"Not Applicable","leadProduct":"Pembrolizumab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Merck & Co","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Merck & Co \/ Merck & Co","highestDevelopmentStatusID":"12","companyTruncated":"Merck & Co \/ Merck & Co"},{"orgOrder":0,"company":"Merck & Co","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Pembrolizumab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Merck & Co","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Merck & Co \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Merck & Co \/ Not Applicable"},{"orgOrder":0,"company":"Merck & Co","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Sotatercept","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Merck & Co","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Merck & Co \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Merck & Co \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Merck & Co

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                            01

                            Merck & Co

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                            Lead Product(s) : Eftilagimod Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Immutep

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Immutep Efti Shows Excellent Survival in INSIGHT-003 Non-Small Cell Lung Cancer

                            Details : IMP321 (eftilagimod alpha), a soluble LAG-3 protein. It is being evaluated in combination with keytruda for first-line treatment of metastatic non-small cell lung cancer.

                            Brand Name : IMP321

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 14, 2024

                            Lead Product(s) : Eftilagimod Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Immutep

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Merck & Co

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                            Merck & Co

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                            Lead Product(s) : mRNA-4157,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Moderna Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck and Moderna Start Phase 3 Trial for V940 with KEYTRUDA in Lung Cancer

                            Details : V940 (mRNA-4157) is a novel investigational messenger RNA (mRNA)-based individualized neoantigen therapy. It is under clinical development for the treatment of non-small cell lung cancer.

                            Brand Name : V940

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            October 28, 2024

                            Lead Product(s) : mRNA-4157,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Moderna Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Merck & Co

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                            Antibody Engineering
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                            Lead Product(s) : Islatravir,Lenacapavir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Recipient : Gilead Sciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck-Gilead Oral Combo Suppresses HIV for 48 Weeks, Preps for Pivotal Program

                            Details : MK-8591 (islatravir) is a non-nucleoside reverse transcriptase translocation inhibitor, which is being investigated in phase 2 for HIV-1 infection, in combination with lenacapavir.

                            Brand Name : MK-8591

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 21, 2024

                            Lead Product(s) : Islatravir,Lenacapavir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Recipient : Gilead Sciences

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Merck & Co

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                            Antibody Engineering
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                            Merck & Co

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                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Recipient : Exelixis

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Exelixis & Merck Collaborate on Zanzalintinib + KEYTRUDA® for Head/Neck Cancer & RCC

                            Details : The collaboration aims to evaluate Exelixis’ TKI XL092 (zanzalintinib) with Merck’s Keytruda (pembrolizumab) for HNSCC, and with Welireg (belzutifan), an oral HIF-2 alpha inhibitor, for RCC.

                            Brand Name : XL092

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 14, 2024

                            Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Recipient : Exelixis

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            Merck & Co

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                            Antibody Engineering
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                            Merck & Co

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                            Lead Product(s) : Favezelimab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck’s Keytruda Combo Fails in Phase III Colorectal Cancer Study

                            Details : MK-4280A (favezelimab/pembrolizumab) is a IV infused LAG3/PD-1 inhibitor antibody, it is being evaluated for the treatment of PD-L1 Positive Microsatellite Stable Metastatic Colorectal Cancer.

                            Brand Name : MK-4280A

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 25, 2024

                            Lead Product(s) : Favezelimab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Organon

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                            Organon

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                            Lead Product(s) : Tapinarof

                            Therapeutic Area : Dermatology

                            Study Phase : Approved

                            Recipient : Dermavant Sciences

                            Deal Size : $1,200.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Organon Pays up to $1.2B to Acquire Dermavant and its Steroid-Free Skin Cream Vtama

                            Details : Through the acquisition, Organon will leverage the Dermavant pipeline, which includes Vtama (tapinarof) cream. It is indicated for the treatment of f plaque psoriasis in adults.

                            Brand Name : Vtama

                            Molecule Type : Small molecule

                            Upfront Cash : $175.0 million

                            September 18, 2024

                            Lead Product(s) : Tapinarof

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved

                            Recipient : Dermavant Sciences

                            Deal Size : $1,200.0 million

                            Deal Type : Acquisition

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                            07

                            Merck & Co

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                            Lead Product(s) : Pembrolizumab,Enfortumab Vedotin

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            European Commission Approves KEYTRUDA® with Padcev® for Urothelial Carcinoma

                            Details : Keytruda (pembrolizumab), an anti-PD-1 therapy, in combination with Padcev (enfortumab vedotin-ejfv), an ADC, is indicated for treating adults with locally advanced or metastatic urothelial carcinoma.

                            Brand Name : Keytruda

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 03, 2024

                            Lead Product(s) : Pembrolizumab,Enfortumab Vedotin

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Merck & Co

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                            Lead Product(s) : Cladribine

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck Doses First Patient in Phase III Oral Cladribine Study for Myasthenia Gravis

                            Details : Mavenclad (Cladribine) is a orally administered DNA synthesis inhibitor. It is being evaluated in for the treatment of Generalized Myasthenia Gravis.

                            Brand Name : Mavenclad

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 29, 2024

                            Lead Product(s) : Cladribine

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Merck & Co

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                            Lead Product(s) : Bomedemstat

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck Starts Phase 3 Trial of Bomedemstat for Essential Thrombocythemia Treatment

                            Details : MK-3543 (bomedemstat) is an investigational orally available small molecule that inhibits LSD1. It is under phase 3 clinical development for the treatment of essential thrombocythemia.

                            Brand Name : MK-3543

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 27, 2024

                            Lead Product(s) : Bomedemstat

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Merck & Co

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                            Lead Product(s) : Sotatercept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Merck's WINREVAIR™ Approved by European Commission for Pulmonary Hypertension

                            Details : Winrevair (sotatercept) is the first activin signaling inhibitor therapy, which is approved for the treatment of adults with pulmonary arterial hypertension.

                            Brand Name : Winrevair

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 26, 2024

                            Lead Product(s) : Sotatercept

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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