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Medicine","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Tepotinib","moa":"","graph1":"Technology","graph2":"Approved","graph3":"EMD Serono","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"EMD Serono \/ EMD Serono","highestDevelopmentStatusID":"12","companyTruncated":"EMD Serono \/ EMD Serono"}]

Find Clinical Drug Pipeline Developments & Deals by Merck Group

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Tepmetko (tepotinib) is a kinase inhibitor indicated for the treatment of adult patients with NSCLC harboring mesenchymalepithelial transition (MET) exon 14 skipping alterations.

                          Brand Name : Tepmetko

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 18, 2024

                          Lead Product(s) : Tepotinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Foundation Medicine

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The collaboration aims to evaluate BND-35 in combination with Merck's anti-EGFR monoclonal antibody Erbitux (cetuximab) in a Phase 1 for unresectable or metastatic solid tumors.

                          Brand Name : BND-35

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : BND-35,Cetuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Biond Biologics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Within the framework of the partnership, MSD is set to conduct a study on a new investigational anti-cancer drug with a particular focus on lung cancer clinical trials.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 10, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : The Department of Health, Abu Dhabi

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The collaboration will leverage Biolojic Design’s AI-driven discovery platform to design therapeutic antibodies for the treatment of cancer and immunological disorders.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 03, 2024

                          Lead Product(s) : Antibody-based Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Biolojic Design

                          Deal Size : $376.3 million

                          Deal Type : Collaboration

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Merck KGaA will provide Aulos a free supply of Bavencio to evaluate in combination with AU-007, which is being under clinical investigation for the treatment of solid tumor cancers.

                          Brand Name : AU-007

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          May 15, 2024

                          Lead Product(s) : AU-007,Aldesleukin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Aulos

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The partnership aims to accelerate the discovery and development of first-in-class antibody-drug conjugates for cancer patients, by leveraging Caris' proprietary ADAPT Biotargeting platform.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Caris Life Sciences

                          Deal Size : $1,400.0 million

                          Deal Type : Partnership

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The collaboration aims to discover 2 targeted protein degraders against critical oncogenic proteins that C4T has progressed its internal discovery pipeline using its proprietary TORPEDO® platform.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : $16.0 million

                          March 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : C4 Therapeutics

                          Deal Size : $756.0 million

                          Deal Type : Collaboration

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Efti (eftilagimod alpha) is being evaluated in phase 1 trials with Bavencio (avelumab) for patients with metastatic urothelial carcinoma.

                          Brand Name : IMP321

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 04, 2024

                          Lead Product(s) : Eftilagimod Alpha,Avelumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Immutep

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Merck gains exclusive rights to RGX-202 (ompenaclid) for RAS-mutated advanced colorectal cancer, with co-development options in the U.S.

                          Brand Name : RGX-202

                          Molecule Type : Small molecule

                          Upfront Cash : $45.0 million

                          January 04, 2024

                          Lead Product(s) : RGX-202,Bevacizumab,Irinotecan Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Inspirna

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Under the agreement, Merck will supply ITM with its first-in-class folate precursors for radiolabeling, which ITM will use to advance the clinical and potential future commercial development of its folate receptor-targeting radiopharmaceutical pipeline, ...

                          Brand Name : ITM-52

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 14, 2023

                          Lead Product(s) : ITM-52

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Isotope Technologies Munich

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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