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therapy","year":"2024","type":"Financing","leadProduct":"Remestemcel-L","moa":"","graph1":"Immunology","graph2":"Approved","graph3":"Mesoblast","amount2":0.050000000000000003,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Immunology","amount2New":0.050000000000000003,"dosageForm":"","sponsorNew":"Mesoblast \/ Gregory George","highestDevelopmentStatusID":"12","companyTruncated":"Mesoblast \/ Gregory George"},{"orgOrder":0,"company":"Mesoblast","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"Rexlemestrocel-L","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Mesoblast","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Mesoblast \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Mesoblast \/ Not Applicable"},{"orgOrder":0,"company":"Mesoblast","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"Rexlemestrocel-L","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Mesoblast","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Mesoblast \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Mesoblast \/ Not Applicable"},{"orgOrder":0,"company":"Mesoblast","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"Remestemcel-L","moa":"","graph1":"Immunology","graph2":"Approved","graph3":"Mesoblast","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Mesoblast \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Mesoblast \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals by Mesoblast

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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Ryoncil is the first mesenchymal stromal cell (MSC) therapy indicated for treatment of steroid-refractory acute graft-versus-host disease in children.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 20, 2024

                          Lead Product(s) : Remestemcel-L

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Revascor (rexlemestrocel-L) is preparation of immunoselected and culture-expanded mesenchymal precursor cells. It is being evaluated for the treatment of children with hypoplastic left heart syndrome.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 04, 2024

                          Lead Product(s) : Rexlemestrocel-L

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Revascor (rexlemestrocel-L) is preparation of immunoselected and culture-expanded mesenchymal precursor cells. It is being evaluated for the treatment of children with hypoplastic left heart syndrome.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 02, 2024

                          Lead Product(s) : Rexlemestrocel-L

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : The proceeds will be used in Mesoblast’s lead product candidate Ryoncil (remestemcel-L) in the treatment of children with steroid-refractory acute graft versus host disease (SR-aGvHD).

                          Product Name : Ryoncil

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 29, 2024

                          Lead Product(s) : Remestemcel-L

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Gregory George

                          Deal Size : $50.0 million

                          Deal Type : Financing

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                          05

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Ryoncil (remestemcel-l) have immunomodulatory properties to counteract the inflammatory processes in SRaGVHD by down-regulating the production of pro-inflammatory cytokines.

                          Product Name : Ryoncil

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 23, 2024

                          Lead Product(s) : Remestemcel-L

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Revascor (rexlemestrocel-L) is preparation of immunoselected and culture-expanded mesenchymal precursor cells. It is being evaluated for the treatment of moderate to severe chronic low back pain.

                          Product Name : Revascor

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 21, 2024

                          Lead Product(s) : Rexlemestrocel-L,Hyaluronic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Ryoncil (remestemcel-L) is an investigational therapy comprising mesenchymal stromal cells, for the treatment of adults with steroid-refractory acute graft versus host disease (SR-aGvHD).

                          Product Name : Ryoncil

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 09, 2024

                          Lead Product(s) : Remestemcel-L

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Prochymal (remestemcel-L) is an off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells, evaluated for pediatric patients with SR-aGVHD.

                          Product Name : Prochymal

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 25, 2024

                          Lead Product(s) : Remestemcel-L

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Revascor (rexlemestrocel-L) is an allogeneic preparation of immunoselected and culture-expanded mesenchymal precursor cells. It is being developed for hypoplastic left heart syndrome in children.

                          Product Name : Revascor

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 14, 2024

                          Lead Product(s) : Rexlemestrocel-L

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          BIO CEO & Investor
                          Not Confirmed
                          BIO CEO & Investor
                          Not Confirmed

                          Details : Revascor (rexlemestrocel-L) is a mesenchymal precursor cell therapy in phase 1/2 trials for treating Hypoplastic Left Heart Syndrome.

                          Product Name : Revascor

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          January 18, 2024

                          Lead Product(s) : Rexlemestrocel-L

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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