Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Methoxsalen
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : CVC Capital Partners
Deal Size : $925.0 million
Deal Type : Acquisition
Mallinckrodt Reaches Agreement to Sell Therakos® Business to CVC for $925 Million
Details : Through the acquisition, CVC will leverage the Company's Therakos Uvadex (methoxsalen), a fully integrated ECP delivery system for skin manifestations of Cutaneous T-cell lymphoma.
Brand Name : Uvadex
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 05, 2024
Lead Product(s) : Methoxsalen
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : CVC Capital Partners
Deal Size : $925.0 million
Deal Type : Acquisition
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Syros Pharmaceuticals
Deal Size : $130.0 million
Deal Type : Private Placement
Syros Announces Closing of Merger with Tyme Technologies and Concurrent Private Placement
Details : SM-88 (racemetyrosine) is an orally administered cancer metabolism-based therapy that is chemically altered to be non-functional for fundamental tumor cell processes, including protein synthesis.
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Undisclosed
September 16, 2022
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Syros Pharmaceuticals
Deal Size : $130.0 million
Deal Type : Private Placement
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Syros Pharmaceuticals
Deal Size : $60.0 million
Deal Type : Merger
Details : In the merger, Syros expects to issue approximately 74.3 million shares of its common stock to TYME stockholders to acquire TYME’s pipeline including SM-88 (D/L-alpha-metyrosine).
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 05, 2022
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Syros Pharmaceuticals
Deal Size : $60.0 million
Deal Type : Merger
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The results that SM-88 alone showed antiproliferative effects in each of the sensitive and resistant cells lines, and that the combination of SM-88 and MPS had an additive effect in these models.
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 09, 2022
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
TYME Technologies, Inc. Provides Update on Precision Promise Trial in Metastatic Pancreatic Cancer
Details : SM-88 (D/L-alpha-metyrosine), with MPS arm of Phase 2/3 platform trial in metastatic pancreatic cancer discontinued for futility on primary endpoint of overall survival.
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 26, 2022
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methoxsalen
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Recruiting Patients for Phase 1 Trial of the X-PACT System in Solid Tumors
Details : The heart of the X-PACT system is 8-MOP (also known as 8-methoxypsoralen or methoxsalen) which has been successfully used for decades in the treatment of autoimmune disease, skin disorders and certain skin and blood cancers.
Brand Name : X-PACT System
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 16, 2021
Lead Product(s) : Methoxsalen
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Tyme Granted U.S. Patent Claims Covering Use of Tyrosine-Based Drug Delivery Method to Treat Cancer
Details : SM-88 is an oral investigational modified proprietary tyrosine derivative that interrupt the metabolic processes of cancer cells by breaking down the cells’ key defenses and leading to cell death through oxidative stress and exposure to the body’s na...
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 26, 2021
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The study demonstrated that SM-88 had promising efficacy and safety outcomes for prostate cancer patients while sparing testosterone. The study also demonstrated a reduction of CTCs that may prove to be a better surrogate for patient outcomes than PSA, p...
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 15, 2020
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
TYME Announces Outcome of Interim Futility Review for HopES Sarcoma Phase II Study
Details : The interim futility review of company's HopES Sarcoma Phase II clinical trial for SM-88 was completed in late July and, based on the analysis of the data and recommendations of Dr. Sant Chawla, the study will proceed with the current trial design as pla...
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 11, 2020
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SM-88 has demonstrated encouraging tumor responses in 15 different cancers across four separate studies with minimal serious grade 3 or higher adverse events .
Brand Name : SM-88
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 03, 2020
Lead Product(s) : Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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