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    [{"orgOrder":0,"company":"Yamo Pharmaceuticals","sponsor":"The Autism Impact Fund","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Financing","leadProduct":"Methyltyrosine","moa":"Tyrosine hydroxylase","graph1":"Neurology","graph2":"Phase II","graph3":"Yamo Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Yamo Pharmaceuticals \/ The Autism Impact Fund","highestDevelopmentStatusID":"8","companyTruncated":"Yamo Pharmaceuticals \/ The Autism Impact Fund"},{"orgOrder":0,"company":"Tyme Technologies","sponsor":"Syros Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Merger","leadProduct":"Methyltyrosine","moa":"||Tyrosine hydroxylase","graph1":"Oncology","graph2":"Phase II\/ Phase 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I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Tyme Technologies \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Tyme Technologies \/ Inapplicable"},{"orgOrder":0,"company":"Tyme Technologies","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Methyltyrosine","moa":"||Tyrosine hydroxylase","graph1":"Oncology","graph2":"Phase II","graph3":"Tyme Technologies","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Tyme Technologies \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Tyme Technologies \/ Inapplicable"},{"orgOrder":0,"company":"Tyme Technologies","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small 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    Methyltyrosine

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    01

    Yamo Pharmaceuticals

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    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Study Phase : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Yamo Pharmaceuticals Reports Positive Data from Phase 2 Study of L1-79 in Autism

    Details : L1-79 is a tyrosine hydroxylase inhibitor expected to modulate the catecholaminergic pathways, and thereby improve the core autism spectrum disorder symptoms.

    Product Name : L1-79

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    July 30, 2024

    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Highest Development Status : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    02

    Yamo Pharmaceuticals

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    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Study Phase : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Yamo Pharmaceuticals Enrolls Final Patient in Phase 2 Study Evaluating L1-79 to Treat the Core Symptoms of Aut...

    Details : L1-79 (DL-alpha-Methyltyrosine) is a tyrosine hydroxylase inhibitor which is under phase 2 clinical development . It is designed to improve the core socialization and communication symptoms of autism spectrum disorder (ASD).

    Product Name : L1-79

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    November 20, 2023

    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Highest Development Status : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    03

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II/ Phase III

    Sponsor : Syros Pharmaceuticals

    Deal Size : $130.0 million

    Deal Type : Private Placement

    DEALS_DEV arrow-down

    Syros Announces Closing of Merger with Tyme Technologies and Concurrent Private Placement

    Details : SM-88 (racemetyrosine) is an orally administered cancer metabolism-based therapy that is chemically altered to be non-functional for fundamental tumor cell processes, including protein synthesis.

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Undisclosed

    September 16, 2022

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Syros Pharmaceuticals

    Deal Size : $130.0 million

    Deal Type : Private Placement

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    04

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    TYME Technologies, Inc. Announces SM-88 Poster at the American Association for Cancer Research (AACR) Annual M...

    Details : The results that SM-88 alone showed antiproliferative effects in each of the sensitive and resistant cells lines, and that the combination of SM-88 and MPS had an additive effect in these models.

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    September 03, 2022

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    05

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II/ Phase III

    Sponsor : Syros Pharmaceuticals

    Deal Size : $60.0 million

    Deal Type : Merger

    DEALS_DEV arrow-down

    Syros to Raise Approximately $190 Million Through Merger with TYME Technologies and Concurrent Private Placeme...

    Details : In the merger, Syros expects to issue approximately 74.3 million shares of its common stock to TYME stockholders to acquire TYME’s pipeline including SM-88 (D/L-alpha-metyrosine).

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Undisclosed

    May 07, 2022

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Syros Pharmaceuticals

    Deal Size : $60.0 million

    Deal Type : Merger

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    06

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II/ Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    TYME Technologies, Inc. Provides Update on Precision Promise Trial in Metastatic Pancreatic Cancer

    Details : SM-88 (D/L-alpha-metyrosine), with MPS arm of Phase 2/3 platform trial in metastatic pancreatic cancer discontinued for futility on primary endpoint of overall survival.

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    January 26, 2022

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    07

    Yamo Pharmaceuticals

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    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Study Phase : Phase II

    Sponsor : The Autism Impact Fund

    Deal Size : Undisclosed

    Deal Type : Financing

    DEALS_DEV arrow-down

    Yamo Pharmaceuticals Receives Investment from Autism Impact Fund to Support Phase 2 Study of L1-79 in Autism S...

    Details : As part of investment in Yamo to support a Phase 2 study of L1-79 in adolescents and adults with ASD. L1-79, the company’s lead candidate, is a tyrosine hydroxylase inhibitor designed to modulate the catecholaminergic pathways implicated in ASD.

    Product Name : L1-79

    Product Type : Other Small Molecule

    Upfront Cash : Undisclosed

    October 11, 2021

    Lead Product(s) : Methyltyrosine

    Therapeutic Area : Neurology

    Highest Development Status : Phase II

    Sponsor : The Autism Impact Fund

    Deal Size : Undisclosed

    Deal Type : Financing

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    08

    Tyme Technologies

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    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II/ Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Tyme Granted U.S. Patent Claims Covering Use of Tyrosine-Based Drug Delivery Method to Treat Cancer

    Details : SM-88 is an oral investigational modified proprietary tyrosine derivative that interrupt the metabolic processes of cancer cells by breaking down the cells’ key defenses and leading to cell death through oxidative stress and exposure to the body’s na...

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    July 26, 2021

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    09

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    TYME Announces Outcome of Interim Futility Review for HopES Sarcoma Phase II Study

    Details : The interim futility review of company's HopES Sarcoma Phase II clinical trial for SM-88 was completed in late July and, based on the analysis of the data and recommendations of Dr. Sant Chawla, the study will proceed with the current trial design as pla...

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    November 08, 2020

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    10

    Tyme Technologies

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    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Study Phase : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    TYME’s Phase II Prostate Cancer Study of SM-88 in Patients with Non-Metastatic Recurrent Prostate Cancer Pub...

    Details : The study demonstrated that SM-88 had promising efficacy and safety outcomes for prostate cancer patients while sparing testosterone. The study also demonstrated a reduction of CTCs that may prove to be a better surrogate for patient outcomes than PSA, p...

    Product Name : SM-88

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    September 15, 2020

    Lead Product(s) : Methyltyrosine,Methoxsalen

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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