[{"orgOrder":0,"company":"Embera NeuroTherapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Metyrapone","moa":"CYP450","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Embera NeuroTherapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral","sponsorNew":"Embera NeuroTherapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Embera NeuroTherapeutics \/ Not Applicable"},{"orgOrder":0,"company":"HRA Pharma","sponsor":"Esteve Healthcare","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"","productType":"Small molecule","year":"2024","type":"Divestment","leadProduct":"Metyrapone","moa":"","graph1":"Endocrinology","graph2":"Approved","graph3":"HRA Pharma","amount2":0.28999999999999998,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Endocrinology","amount2New":0.28999999999999998,"dosageForm":"Soft gel Capsule","sponsorNew":"HRA Pharma \/ Esteve Healthcare","highestDevelopmentStatusID":"12","companyTruncated":"HRA Pharma \/ Esteve Healthcare"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Esteve expands its rare disease portfolio through divestment, including Metopirone (metyrapone) for treating symptoms of Cushing's syndrome by lowering cortisol levels.

                          Brand Name : Metopirone

                          Molecule Type : Small molecule

                          Upfront Cash : $203.3 million

                          April 25, 2024

                          Lead Product(s) : Metyrapone

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved

                          Sponsor : Esteve Healthcare

                          Deal Size : $294.2 million

                          Deal Type : Divestment

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
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                          Details : The randomized, double-blind, placebo-controlled Phase 2 clinical trial is supported by funding from the National Institute on Drug Abuse (NIDA) of the National Institutes of Health and will evaluate EMB-001 as a treatment option for patients with cocain...

                          Brand Name : EMB-001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 31, 2020

                          Lead Product(s) : Metyrapone,Oxazepam

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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