Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Mission Therapeutics Awarded $5.2M from Michael J. Fox Foundation and Parkinson's UK
Details : The funding aims to support the company's investigattional product MTX325 brain-penetrant USP30 inhibitor. It is being evaluated in early-stage studies for the treatment of Parkinson's disease.
Brand Name : MTX325
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 02, 2024
Lead Product(s) : MTX652
Therapeutic Area : Nephrology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MTX652 is a potent and selective compound designed to improve mitochondrial quality and function by enhancing mitophagy through inhibition of USP30 enzyme. It is being evaluated for the treatment of acute kidney injury (AKI) following cardiac surgery.
Brand Name : MTX652
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 14, 2023
Lead Product(s) : MTX652
Therapeutic Area : Nephrology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : MTX325
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MTX325 is a USP30 inhibitor small molecule drug candidate, which is currently being evaluated in clinical trial studies with patients for the treatment of parkinson's disease.
Brand Name : MTX325
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 05, 2023
Lead Product(s) : MTX325
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : MTX652
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Mission Therapeutics Successfully Completes First Clinical Assessment for Lead DUB Program, MTX652
Details : MTX652 potently and specifically inhibits USP30 with the aim of enabling appropriate degradation of dysfunctional mitochondria to preserve overall mitochondrial quality and improve cellular health.
Brand Name : MTX652
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 05, 2023
Lead Product(s) : MTX652
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : MTX652
Therapeutic Area : Nephrology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Mission has developed MTX652 to inhibit USP30 with the aim to enable appropriate degradation of dysfunctional mitochondria to preserve and improve cellular health. Mission is also investigating the potential of USP30 inhibitors to treat these diseases.
Brand Name : MTX652
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 31, 2022
Lead Product(s) : MTX652
Therapeutic Area : Nephrology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Michael J. Fox Foundation
Deal Size : $0.5 million
Deal Type : Financing
Mission Therapeutics Awarded Follow-On Therapeutic Pipeline Programme Grant From MJFF
Details : The research grant will support testing of Mission’s lead CNS-penetrant USP30 DUB inhibitors in an in vivo model of Familial Parkinson’s Disease (PD), as well as ongoing preclinical development towards candidate selection.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 12, 2021
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Michael J. Fox Foundation
Deal Size : $0.5 million
Deal Type : Financing
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Discovery
Sponsor : AbbVie Inc
Deal Size : $20.0 million
Deal Type : Collaboration
Mission and AbbVie deal in Alzheimer’s and Parkinson Reaches Next Milestone
Details : Under the terms of the agreement, first announced in 2018, Mission and AbbVie are collaborating to identify novel DUB targets and discover associated inhibitor compounds for neurodegenerative diseases.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 09, 2021
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Discovery
Sponsor : AbbVie Inc
Deal Size : $20.0 million
Deal Type : Collaboration
Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Study Phase : Preclinical
Sponsor : Pfizer Inc
Deal Size : $15.0 million
Deal Type : Financing
Mission Raises $15m and Expands its Relationship with Pfizer
Details : The new capital will support development of Mission’s world-leading DUB platform, as well as growth of its pipeline of DUB inhibitor programmes.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 06, 2020
Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Highest Development Status : Preclinical
Sponsor : Pfizer Inc
Deal Size : $15.0 million
Deal Type : Financing
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