[{"orgOrder":0,"company":"Priothera","sponsor":"Fountain Healthcare","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2020","type":"Series A Financing","leadProduct":"Mocravimod","moa":"S1PR","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.040000000000000001,"dosageForm":"Oral","sponsorNew":"Priothera \/ Fountain Healthcare","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Fountain Healthcare"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Mocravimod","moa":"S1PR","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Mocravimod","moa":"S1PR","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Mocravimod","moa":"S1PR","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Mocravimod","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Mocravimod","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"Priothera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"IRELAND","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Mocravimod","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Priothera","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Priothera \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Priothera \/ Not Applicable"},{"orgOrder":0,"company":"EUROAPI","sponsor":"Priothera","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"Small molecule","year":"2024","type":"Collaboration","leadProduct":"Mocravimod","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"EUROAPI","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"EUROAPI \/ Priothera","highestDevelopmentStatusID":"10","companyTruncated":"EUROAPI \/ Priothera"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Priothera

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : The collaboration aims to support Protheria for the development and manufacturing KRP203 (mocravimod), which is being evaluated in the late-stage for the treatment of adult acute myeloid leukemia.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 18, 2024

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Priothera

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          EUROAPI Compnay Banner

                          02

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Mocravimod, a sphingosine-1-phosphate (S1P) receptor modulator, is being investigated in a pivotal global Phase 3 study 'treatment of acute myeloid leukemia (AML).

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 27, 2023

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : KRP203 (mocravimod) is a synthetic, sphingosine 1-phosphate receptor (S1PR) modulator. It is currently in phase 3 study for acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 27, 2023

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : KRP203 (mocravimod) is a synthetic, sphingosine 1-phosphate receptor (S1PR) modulator. This drug is in Phase 1 and Phase 2 trials for safety and tolerability, as well as for efficacy in several autoimmune indications such as AML patients undergoing HCT.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 23, 2023

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Lead Product(s) : Mocravimod,Allogenic Hematopoietic Stem Cell Transplant

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Mocravimod (also known as KRP203), is a synthetic, sphingosine 1-phosphate receptor (S1PR) modulator. This novel investigational drug has been assessed in Phase 1 and Phase 2 trials for safety and tolerability, as well as for efficacy in several autoimmu...

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 31, 2022

                          Lead Product(s) : Mocravimod,Allogenic Hematopoietic Stem Cell Transplant

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Global Phase 2b/3 trial (MO-TRANS) assessing the efficacy and safety of mocravimod, a novel S1P receptor modulator, as an adjunctive and maintenance therapy in AML patients undergoing allogeneic HSCT, planned to start in H2 2022.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 26, 2022

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : KRP203 (mocravimod), a novel, synthetic, sphingosine 1-phosphate receptor modulator developed as a potential best-in-class adjunctive and maintenance therapy to enhance the curative potential of HSCT for AML patients.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 03, 2022

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Priothera will use the funds to progress the clinical development of mocravimod, a modulator of sphingosine 1 phosphate (S1P) receptors, to enhance the curative potential of allogenic hematopoietic stem cell transplantation (HSCT) for treating AML.

                          Brand Name : KRP203

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 12, 2020

                          Lead Product(s) : Mocravimod

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Fountain Healthcare

                          Deal Size : $35.4 million

                          Deal Type : Series A Financing

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