Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Ayrmid
Deal Size : $97.0 million
Deal Type : Licensing Agreement
BioLineRx and Ayrmid Partner to Commercialize APHEXDA® Through Gamida Cell
Details : BioLineRx granted Ayrmid an exclusive license to develop and commercialize Aphexda (motixafortide) across all indications, excluding solid tumor indications, and in all territories other than Asia.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : $10.0 million
November 21, 2024
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Ayrmid
Deal Size : $97.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Motixafortide,Cemiplimab,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Highbridge Capital Management
Deal Size : $9.0 million
Deal Type : Financing
BioLineRx & Ayrmid Enter into Exclusive License Agreement to Commercialize APHEXDA
Details : BioLineRx will continue the development of Aphexda (motixafortide) for pancreatic ductal adenocarcinoma (PDAC).
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Undisclosed
November 21, 2024
Lead Product(s) : Motixafortide,Cemiplimab,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Highbridge Capital Management
Deal Size : $9.0 million
Deal Type : Financing
Lead Product(s) : Motixafortide
Therapeutic Area : Hematology
Study Phase : Phase I
Sponsor : St. Jude Children's Research Hospital
Deal Size : Undisclosed
Deal Type : Agreement
BioLineRx and St. Jude Evaluate Motixafortide for CD34+ HSC Mobilization
Details : The agreement aims to evaluate motixafortide for the mobilization of CD34+ hematopoietic stem cells (HSCs) used in the development of gene therapies for patients with sickle cell disease (SCD).
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Undisclosed
May 30, 2024
Lead Product(s) : Motixafortide
Therapeutic Area : Hematology
Highest Development Status : Phase I
Sponsor : St. Jude Children's Research Hospital
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : BlackRock
Deal Size : Undisclosed
Deal Type : Financing
BioLineRx Accesses Second Tranche of $20M Under $40M Non-Dilutive Debt Financing Agreement
Details : The net proceeds will be used to advance the commercialization of APHEXDA (motixafortide) approved in the U.S. for stem cell mobilization for autologous transplantation in multiple myeloma.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Undisclosed
April 10, 2024
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : BlackRock
Deal Size : Undisclosed
Deal Type : Financing
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : JonesTrading Institutional Services
Deal Size : $6.0 million
Deal Type : Public Offering
BioLineRx Announces $6 Million Registered Direct Offering
Details : BioLineRx plans to use proceeds for the commercialization of APHEXDA (motixafortide) in the U.S. for stem cell mobilization in multiple myeloma patients.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Undisclosed
April 01, 2024
Lead Product(s) : Motixafortide,Filgrastim
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : JonesTrading Institutional Services
Deal Size : $6.0 million
Deal Type : Public Offering
Lead Product(s) : Motixafortide,Cemiplimab,Gemcitabine
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
BioLineRx Announces First Patient Dosed in Phase 2 Trial Evaluating Motixafortide in PDAC
Details : BL-8040 (motixafortide) is a CXCR4 inhibitor, which is being evaluated in combination with cemiplimab, and standard of care chemotherapies for the treatment of Pancreatic ductal adenocarcinoma.
Brand Name : BL-8040
Molecule Type : Peptide
Upfront Cash : Not Applicable
February 28, 2024
Lead Product(s) : Motixafortide,Cemiplimab,Gemcitabine
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Motixafortide,Natalizumab
Therapeutic Area : Hematology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BioLineRx initiated Phase I clinical trial studies evaluating BL-8040 (motixafortide), CXCR4/SDF-1 inhibitor, as monotherapy and in combination with natalizumab for the treatment of sickle cell disease.
Brand Name : BL-8040
Molecule Type : Peptide
Upfront Cash : Not Applicable
December 21, 2023
Lead Product(s) : Motixafortide,Natalizumab
Therapeutic Area : Hematology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Motixafortide,G-CSF
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Gloria Biosciences
Deal Size : $279.6 million
Deal Type : Licensing Agreement
BioLineRx Entered Exclusive License Agreement with Motixafortide in Asia, Advised by MSQ Ventures
Details : Under the agreement, BioLineRx gain the rights for the development of Aphexda (motixafortide), a CXCR4 antagonist, in stem cell mobilization and pancreatic cancer, in Asia.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : $29.6 million
October 31, 2023
Lead Product(s) : Motixafortide,G-CSF
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Gloria Biosciences
Deal Size : $279.6 million
Deal Type : Licensing Agreement
Lead Product(s) : Motixafortide,Natalizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Aphexda (motixafortide) is a CXCR4 antagonist , which is investigated in combination with gemcitabine and nab-paclitaxel, versus gemcitabine and nab-paclitaxel alone, in first-line pancreatic cancers.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 28, 2023
Lead Product(s) : Motixafortide,Natalizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Motixafortide,G-CSF
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : APHEXDA (motixafortide) is a CXCR4 antagonist , which is investigated in combination with filgrastim to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma.
Brand Name : Aphexda
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 11, 2023
Lead Product(s) : Motixafortide,G-CSF
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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