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                          01

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : MRT-2359 is a potent, highly selective, and orally bioavailable investigational molecular glue degrader. Currently,It is being evaluated for the treatment of MYC-driven solid tumors.

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 27, 2024

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : Monte Rosa intends to use the proceeds towards the advancement of its clinical and late preclinical pipeline, including MRT-2359, its orally bioavailable, GSPT1-directed MGD, MRT-6160, its orally bioavailable VAV1-directed MGD, and its NEK7 program.

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 26, 2023

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : $25.0 million

                          Deal Type : Public Offering

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                          03

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : MRT-2359 is a orally bioavailable investigational molecular glue degrader (MGD) that induces the interaction between the E3 ubiquitin ligase component cereblon and the translation termination factor GSPT1, leading to the targeted degradation of GSPT1 pro...

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 17, 2023

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : MRT-2359 is a potent, selective and orally bioavailable molecular glue degrader (MGD) that induces the interaction between the E3 ubiquitin ligase component cereblon (CRBN) and the translation termination factor GSPT1, leading to the targeted degradation...

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 01, 2022

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : MRT-2359 is a potent, selective and orally bioavailable molecular glue degrader (MGD) that induces the interaction between the E3 ubiquitin ligase component cereblon (CRBN) and the translation termination factor GSPT1, leading to the targeted degradation...

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 06, 2022

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : MRT-2359 induces degradation of GSPT1 and associated downregulation of N-Myc and its transcriptional output, leading to preferential anti-proliferative activity in lung cancer cell lines with high L-Myc and N-Myc mRNA expression.

                          Brand Name : MRT-2359

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 08, 2022

                          Lead Product(s) : MRT-2359

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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