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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : KMN-159

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : KMN-159 is the lead compound from a series of novel difluorolactam prostanoid EP4 receptor agonists.

                          Product Name : KMN-159

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 05, 2023

                          Lead Product(s) : KMN-159

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Cayman

                          02

                          Details : The grant will be used to explore Cayman’s patented small molecule bone repair agent KMN-159 as the active pharmaceutical ingredient (API) in a drug-device combination to improve the mechanical anchorage of dental titanium implants into the jawbone.

                          Product Name : KMN-159

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          September 16, 2021

                          Lead Product(s) : KMN-159,Collagen

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : NIDCR

                          Deal Size : $1.7 million

                          Deal Type : Funding

                          Cayman

                          03

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : ALG-001 (hydrocelin), is an injectable microparticle hydrogel, which is currently being evaluated for the treatment of patients with osteoarthritis.

                          Product Name : ALG-001

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          March 25, 2025

                          Lead Product(s) : Hydrocelin

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Johns Hopkins University

                          Country arrow
                          German Wound Congress
                          Not Confirmed

                          Johns Hopkins University

                          Country arrow
                          German Wound Congress
                          Not Confirmed

                          Details : The licensed technology covers the use of inhibitors of an enzyme termed GCPII (glutamate carboxypeptidase II) for the treatment of sarcopenia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          March 06, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Allosteric Bioscience

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          05

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : ALG-001 (hydrocelin) is an injectable microparticle hydrogel designed as a potential disease-modifying treatment for osteoarthritis. It is being evaluated in preclinical studies.

                          Product Name : ALG-001

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          March 04, 2025

                          Lead Product(s) : Hydrocelin

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : SP-26 is a ketamine HCl-based injectable dissolvable polymer implant for the treatment of chronic pain and fibromyalgia.

                          Product Name : SP-26

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          February 11, 2025

                          Lead Product(s) : Ketamine Hydrochloride

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : The financing aims to advance the company's lead product Telomir-1. It is being evaluated for the treatment of osteoarthritis and Aging.

                          Product Name : Telomir-1

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 12, 2024

                          Lead Product(s) : Telomir-1

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Starwood Trust

                          Deal Size : $1.0 million

                          Deal Type : Financing

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                          08

                          Kymanox

                          Country arrow
                          German Wound Congress
                          Not Confirmed

                          Kymanox

                          Country arrow
                          German Wound Congress
                          Not Confirmed

                          Details : The collaboration with Kymanox aims for design and development of a subcutaneous insertion device for SP-26, the Company’s ketamine-loaded implant therapeutic targeting fibromyalgia and chronic pain.

                          Product Name : SP-26

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          November 29, 2024

                          Lead Product(s) : Ketamine Hydrochloride

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Silo Pharma

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : Telomir-1 is the first novel small molecule, which is proposed to be dosed orally, to lengthen the DNA’s protective telomere caps in order to potentially reverse age-related conditions.

                          Product Name : Telomir-1

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 21, 2024

                          Lead Product(s) : Telomir-1

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          German Wound Congress
                          Not Confirmed
                          German Wound Congress
                          Not Confirmed

                          Details : SP-26 is a ketamine HCl-based injectable dissolvable polymer implant beng investigated for the treatment of chronic pain and fibromyalgia.

                          Product Name : SP-26

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : Ketamine Hydrochloride

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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