Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Not Applicable
Deal Type : Not Applicable
Ensysce Biosciences' PF614-MPAR Enters Final Stage of Phase 1 Study
Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Not Applicable
January 25, 2023
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensysce Reports Positive Progress in PF614-MPAR Pain Treatment Trial
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Controlled Substance
Upfront Cash : Inapplicable
February 05, 2025
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : PF614,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensysce Biosciences Announces Positive Interim Data for Breakthrough Therapy PF614-MPAR
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Controlled Substance
Upfront Cash : Inapplicable
January 22, 2025
Lead Product(s) : PF614,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nafamostat
Therapeutic Area : Nephrology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Talphera Enrolls First Patient in Trial for Nafamostat in Extracorporeal Circuit
Details : Talphera's lead product candidate, Niyad is a lyophilized formulation of nafamostat mesylate and is currently being studied under an IDE as an anticoagulant for the extracorporeal circuit.
Product Name : Niyad
Product Type : Small molecule
Upfront Cash : Not Applicable
August 19, 2024
Lead Product(s) : Nafamostat
Therapeutic Area : Nephrology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
AcelRx Receives IDE Approval for Niyad and Advances to a Single Registration Study
Details : Niyad (a lyophilized formulation of nafamostat), an investigational broad-spectrum serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing and potential anti-viral activities, towards an FDA approval.
Product Name : Niyad
Product Type : Small molecule
Upfront Cash : Not Applicable
October 03, 2023
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Study Phase : Phase III
Sponsor : H.C. Wainwright & Co.
Deal Size : $26.3 million
Deal Type : Private Placement
Details : The net proceeds will be used to advance Niyad (nafamostat), an investigational broad-spectrum serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing and potential anti-viral activities, towards an FDA approval.
Product Name : Niyad
Product Type : Small molecule
Upfront Cash : Undisclosed
July 21, 2023
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Highest Development Status : Phase III
Sponsor : H.C. Wainwright & Co.
Deal Size : $26.3 million
Deal Type : Private Placement
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Not Applicable
February 14, 2023
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Quotient Sciences
Deal Size : Undisclosed
Deal Type : Partnership
Details : PF614-MPAR (oxycodone prodrug) is a novel opioid combination product for the potential treatment of chronic pain that is designed to prevent both abuse and overdose. This partnership serves as validation of the mission and ultimately the platforms.
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Undisclosed
August 31, 2022
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Quotient Sciences
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Study results demonstrate that nafamostat had similar efficacy as citrate, while providing lower toxicity and lower costs to the hospital over standard citrate anticoagulation.
Product Name : Niyad
Product Type : Small molecule
Upfront Cash : Not Applicable
March 29, 2022
Lead Product(s) : Nafamostat
Therapeutic Area : Hematology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Oxycodone Prodrug,Nafamostat,Naltrexone Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The Part A of the trial evaluated three dose levels of PF614 showed positive review from the Phase 1b tria, independent Safety Review Committee allowed the trial to proceed to the next dose level.
Product Name : PRF06104
Product Type : Small molecule
Upfront Cash : Not Applicable
January 04, 2022
Lead Product(s) : Oxycodone Prodrug,Nafamostat,Naltrexone Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable