15
ALL15
Trevi TherapeuticsYear
15
ALL2
20253
20241
20237
20221
20211
2020DEALS // DEV.
15
ALL4
Deals11
DevelopmentsCountry
15
ALL15
U.S.A15
ALL1
Adage Capital Partners1
Frazier Life Sciences11
Inapplicable1
SVB Securities1
StifelTherapeutic Area
15
ALL4
Dermatology11
Pulmonary/Respiratory DiseasesStudy Phase
15
ALL4
Phase II/ Phase III11
Phase IIDeal Type
15
ALL11
Inapplicable2
Private Placement2
Public OfferingProduct Type
15
ALL15
Controlled SubstanceDosage Form
15
ALL14
Oral Tablet, Extended Release1
UndisclosedLead Product
15
ALL15
Nalbuphine HydrochlorideTarget
15
ALL15
Kappa opioid receptorLead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Trevi Reports Positive Phase 2a Data for Haduvio in Chronic Cough
Details : Haduvio (nalbuphine) is a centrally and peripherally acting investigational therapy which is under development for the treatment of patients with refractory chronic cough.
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
March 10, 2025
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Trevi Completes Enrollment for Haduvio Phase 2b in IPF
Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under development for the treatment of idiopathic pulmonary fibrosis patients with chronic cough.
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
February 25, 2025
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Adage Capital Partners
Deal Size : $50.0 million
Deal Type : Public Offering
Trevi Therapeutics Announces Pricing of $50 Million Underwritten Offering
Details : The net proceeds will be used to fund the clinical development of company's lead product Haduvio (nalbuphine) for the treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis.
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Undisclosed
December 16, 2024
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Adage Capital Partners
Deal Size : $50.0 million
Deal Type : Public Offering
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Trevi Finds Positive Human Abuse Potential Data for Oral Nalbuphine Therapy
Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under phase 2 clinical development for the treatment of refractory chronic cough (RCC).
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
December 03, 2024
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Trevi Completes Phase 2a RIVER Trial Enrollment for Chronic Cough
Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under development for the treatment of chronic cough in idiopathic pulmonary fibrosis.
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
October 21, 2024
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under phase 2 clinical development for the treatment of refractory chronic cough (RCC).
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
February 11, 2023
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : SVB Securities
Deal Size : $55.0 million
Deal Type : Public Offering
Trevi Therapeutics Announces Pricing of $55 Million Public Offering
Details : The company will use the net proceeds from the offering for the development of clinical pipeline including its lead product Haduvio (nalbuphine) and for other general and corporate purpose.
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Undisclosed
September 23, 2022
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : SVB Securities
Deal Size : $55.0 million
Deal Type : Public Offering
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Primary efficacy endpoint demonstrated 77.3% reduction in daytime cough frequency from baseline with use of Haduvio (nalbuphine ER) compared to 25.7% reduction with placebo, 52% placebo-adjusted reduction in geometric mean percent change in daytime cough...
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
August 24, 2022
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Frazier Life Sciences
Deal Size : $55.0 million
Deal Type : Private Placement
Trevi Therapeutics Announces $55 Million Private Placement Priced At-the-Market
Details : Company intends to use net proceeds from the private placement for the clinical development of Haduvio (Nalbuphine ER), a mixed ĸ-opioid receptor agonist and µ-opioid receptor antagonist for chronic cough in IPF and working capital and other general co...
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Undisclosed
July 04, 2022
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Frazier Life Sciences
Deal Size : $55.0 million
Deal Type : Private Placement
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Haduvio (oral nalbuphine ER) demonstrated statistically significant results on the primary efficacy endpoint as measured by a 4-point reduction in the Worst Itch – Numerical Rating Scale (WI-NRS) (p=0.0157).
Product Name : Haduvio
Product Type : Controlled Substance
Upfront Cash : Inapplicable
June 29, 2022
Lead Product(s) : Nalbuphine Hydrochloride
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable