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Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Trevi Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Nalbuphine Hydrochloride","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Trevi Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Trevi Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Trevi Therapeutics \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals for Nalbuphine Hydrochloride

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under development for the treatment of chronic cough in idiopathic pulmonary fibrosis.

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 21, 2024

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Haduvio (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which is under phase 2 clinical development for the treatment of refractory chronic cough (RCC).

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 02, 2023

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The company will use the net proceeds from the offering for the development of clinical pipeline including its lead product Haduvio (nalbuphine) and for other general and corporate purpose.

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 23, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : SVB Securities

                          Deal Size : $55.0 million

                          Deal Type : Public Offering

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                          04

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Primary efficacy endpoint demonstrated 77.3% reduction in daytime cough frequency from baseline with use of Haduvio (nalbuphine ER) compared to 25.7% reduction with placebo, 52% placebo-adjusted reduction in geometric mean percent change in daytime cough...

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 24, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Haduvio (oral nalbuphine ER) demonstrated statistically significant results on the primary efficacy endpoint as measured by a 4-point reduction in the Worst Itch – Numerical Rating Scale (WI-NRS) (p=0.0157).

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 29, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Company intends to use net proceeds from the private placement for the clinical development of Haduvio (Nalbuphine ER), a mixed ĸ-opioid receptor agonist and µ-opioid receptor antagonist for chronic cough in IPF and working capital and other general co...

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 07, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Frazier Life Sciences

                          Deal Size : $55.0 million

                          Deal Type : Private Placement

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                          07

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The primary efficacy endpoint demonstrated a 77.3% reduction in daytime cough frequency from baseline with use of Haduvio compared to a 25.7% reduction with placebo, demonstrating a 52% placebo-adjusted reduction in geometric mean percent change in dayt...

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 15, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Interim analysis showed primary efficacy endpoint of cough reduction was highly statistically significant (p<0.0001) for Haduvio (nalbuphine ER) in idiopathic pulmonary fibrosis patients (IPF) suffering from chronic cough, establishing proof of concept.

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 26, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Phase 2b/3 PRISM trial enrollment completed for Haduvio (nalbuphine ER), mixed ĸ-opioid receptor agonist and µ-opioid receptor antagonist for the treatment of pruritus associated with prurigo nodularis.

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 01, 2022

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The Company will use the net proceeds from the private placement for the development of an investigational therapy Haduvio™, an oral extended-release (ER) formulation of nalbuphine to treat serious neurologically mediated conditions.

                          Brand Name : Haduvio

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 30, 2021

                          Lead Product(s) : Nalbuphine Hydrochloride

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Stifel

                          Deal Size : $11.8 million

                          Deal Type : Private Placement

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