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    [{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2021","type":"Inapplicable","leadProduct":"Arsenic Trioxide","moa":"||RAR-alpha","graph1":"Oncology","graph2":"Phase III","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"National Cancer Institute \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"National Cancer Institute \/ Inapplicable"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Eureka Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Cancer Institute \/ Eureka Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"National Cancer Institute \/ Eureka Therapeutics"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2020","type":"Inapplicable","leadProduct":"Docetaxel","moa":"Tubulin","graph1":"Oncology","graph2":"Phase I","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"National Cancer Institute \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"National Cancer Institute \/ Inapplicable"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Sapience Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Collaboration","leadProduct":"ST101","moa":"C\/EBP-beta","graph1":"Oncology","graph2":"Preclinical","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"National Cancer Institute \/ Sapience Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"National Cancer Institute \/ Sapience Therapeutics"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"PDS Biotechnology","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Agreement","leadProduct":"PDS0103","moa":"MUC1","graph1":"Oncology","graph2":"Preclinical","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Cancer Institute \/ PDS Biotechnology","highestDevelopmentStatusID":"4","companyTruncated":"National Cancer Institute \/ PDS Biotechnology"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Elicio Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Collaboration","leadProduct":"ELI-002","moa":"KRAS","graph1":"Oncology","graph2":"IND Enabling","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"National Cancer Institute \/ Elicio Therapeutics","highestDevelopmentStatusID":"5","companyTruncated":"National Cancer Institute \/ Elicio Therapeutics"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Propella Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Partnership","leadProduct":"Abiraterone Decanoate","moa":"CYP17","graph1":"Oncology","graph2":"IND Enabling","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"National Cancer Institute \/ Propella Therapeutics","highestDevelopmentStatusID":"5","companyTruncated":"National Cancer Institute \/ Propella Therapeutics"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Ascentage Pharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Agreement","leadProduct":"Pelcitoclax","moa":"||BCL-2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"National Cancer Institute \/ Ascentage Pharma","highestDevelopmentStatusID":"7","companyTruncated":"National Cancer Institute \/ Ascentage Pharma"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Navrogen","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2022","type":"Agreement","leadProduct":"NAV-001","moa":"MSLN","graph1":"Oncology","graph2":"IND Enabling","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"National Cancer Institute \/ Navrogen","highestDevelopmentStatusID":"5","companyTruncated":"National Cancer Institute \/ Navrogen"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Sumitomo Pharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"JAPAN","productType":"Other Small Molecule","year":"2025","type":"Agreement","leadProduct":"Enzomenib","moa":"MLL-Menin interaction","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"National Cancer Institute","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"National Cancer Institute \/ National Cancer Institute","highestDevelopmentStatusID":"7","companyTruncated":"National Cancer Institute \/ National Cancer Institute"}]

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                            01

                            National Cancer Institute

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                            Lead Product(s) : Enzomenib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Recipient : Sumitomo Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Sumitomo Pharma America Enters into a CRADA with the National Cancer Institute

                            Details : The collaboration aims to evaluate DSP-5336 (enzomenib), an oral, small molecule designed to inhibit the menin and KMT2A protein interaction present in certain difficult to treat cancers.

                            Product Name : DSP-5336

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            April 14, 2025

                            Lead Product(s) : Enzomenib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Sumitomo Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Eureka Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            Eureka Therapeutics Licenses Promising Antibody Targeting Mesothelin from the National Cancer Institute

                            Details : Under the licensing agreement, Eureka will develop and commercialize a novel antibody targeting MSLN, a potentially transformative T-cell therapy for solid tumors, in combination with ARTEMIS® T-cell receptor platform.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            March 14, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Eureka Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            Lead Product(s) : NAV-001

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Navrogen

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            Navrogen Enters into CRADA with The U.S. National Cancer Institute for the Clinical Development of NAV-001, an...

                            Details : NAV-001 targets tumors expressing the cancer antigen mesothelin, a cell surface protein over-expressed on various malignancies, including breast, colon, lung and mesothelioma cancers.

                            Product Name : NAV-001

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Undisclosed

                            July 11, 2022

                            Lead Product(s) : NAV-001

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Navrogen

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            04

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                            Lead Product(s) : Arsenic Trioxide,Tretinoin

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Drug Combination Helps Children with Acute Promyelocytic Leukemia Avoid Conventional Chemotherapy

                            Details : A clinical trial has found that the combination of all-trans retinoic acid, which is a metabolite of vitamin A, and arsenic trioxide is highly effective in children with standard- and high-risk acute promyelocytic leukemia, or APL.

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            December 11, 2021

                            Lead Product(s) : Arsenic Trioxide,Tretinoin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

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                            Lead Product(s) : Pelcitoclax,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Ascentage Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Ascentage Pharma Establishes Cooperative R&D Agreement (CRADA) with the NIH

                            Details : Ascentage Pharma and the NCI will collaborate on a series of clinical trials to evaluate the safety and efficacy of pelcitoclax, Ascentage Pharma's dual inhibitor of BCL-2 and BCL-xL proteins, in solid tumors based upon encouraging anti-tumor activity.

                            Product Name : APG-1252

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            July 19, 2021

                            Lead Product(s) : Pelcitoclax,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Ascentage Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

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                            Lead Product(s) : ST101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Sapience Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Sapience Therapeutics Enters Into Collaboration with National Cancer Institute (NCI) to Study ST101 Response i...

                            Details : ST101, a first-in-class peptide antagonist of C/EBPβ, will be investigated for its impact on primary and metastatic cancer and the tumor microenvironment, leveraging NCI's expertise in C/EBP biology and genetic mouse models

                            Product Name : ST101

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            May 27, 2021

                            Lead Product(s) : ST101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Sapience Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

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                            Lead Product(s) : Abiraterone Decanoate

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Propella Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            Propella Therapeutics Partners with National Cancer Institute to Develop New Treatment for Metastatic Prostate...

                            Details : Under this new partnership, Propella and NCI will conduct a multi-center clinical trial to evaluate abiraterone decanoate, as a new therapy for metastatic prostate cancer.

                            Product Name : PRL-02

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            February 23, 2021

                            Lead Product(s) : Abiraterone Decanoate

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Propella Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            08

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                            Lead Product(s) : PDS0103

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : PDS Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            PDS Biotechnology Expands CRADA with the National Cancer Institute to Include Second Versamune®-Based Anti-Ca...

                            Details : This expansion adds to the NCI’s ongoing evaluation of PDS0101 in combination with two separate immune-modulating agents, NHS-IL12 and M7824 to treat advanced HPV-associated cancers.

                            Product Name : PDS0103

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            April 29, 2020

                            Lead Product(s) : PDS0103

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : PDS Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            Lead Product(s) : ELI-002

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Elicio Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Elicio Therapeutics and National Cancer Institute Collaborate to Study ELI-002 Mutant KRAS Targeting Mechanism

                            Details : This collaborative study investigates the mechanism of action of ELI-002 in mice that have key human HLA genes important for immune response.

                            Product Name : ELI-002

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            April 16, 2020

                            Lead Product(s) : ELI-002

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Elicio Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Lead Product(s) : Docetaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            LIDDS: Second patient treated in the Phase I study, NZ-DTX-001

                            Details : The NZ-DTX-001 study is a multi-center study including Karolinska University Hospital in Sweden, Herlev Hospital in Denmark, Kaunas University Hospital and Vilnius National Cancer Institute.

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            February 19, 2020

                            Lead Product(s) : Docetaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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