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    [{"orgOrder":0,"company":"National Eye Institute","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Not Applicable","leadProduct":"I27-Breg","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"National Eye Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"National Eye Institute \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"National Eye Institute \/ Not Applicable"},{"orgOrder":0,"company":"National Eye Institute","sponsor":"Trethera","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Funding","leadProduct":"TRE-515","moa":"dCK","graph1":"Oncology","graph2":"Phase I","graph3":"National Eye Institute","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"National Eye Institute \/ National Eye Institute","highestDevelopmentStatusID":"6","companyTruncated":"National Eye Institute \/ National Eye Institute"},{"orgOrder":0,"company":"National Eye Institute","sponsor":"Praetego","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Funding","leadProduct":"PTG-630","moa":"","graph1":"Neurology","graph2":"Preclinical","graph3":"National Eye Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"National Eye Institute \/ National Eye Institute","highestDevelopmentStatusID":"4","companyTruncated":"National Eye Institute \/ National Eye Institute"},{"orgOrder":0,"company":"National Eye Institute","sponsor":"iVeena","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Funding","leadProduct":"IVMED-85","moa":"","graph1":"Ophthalmology","graph2":"Phase I\/ Phase II","graph3":"National Eye Institute","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution\/Drops","sponsorNew":"National Eye Institute \/ National Eye Institute","highestDevelopmentStatusID":"7","companyTruncated":"National Eye Institute \/ National Eye Institute"},{"orgOrder":0,"company":"National Eye Institute","sponsor":"RevOpsis Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"DENMARK","productType":"Large molecule","year":"2024","type":"Funding","leadProduct":"RO-104","moa":"","graph1":"Technology","graph2":"Approved","graph3":"National Eye Institute","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"National Eye Institute \/ National Eye Institute","highestDevelopmentStatusID":"12","companyTruncated":"National Eye Institute \/ National Eye Institute"}]

    Find Clinical Drug Pipeline Developments & Deals by National Eye Institute

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                            01

                            National Eye Institute

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                            Lead Product(s) : RO-104

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Recipient : RevOpsis Therapeutics

                            Deal Size : $1.8 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            RevOpsis Wins $1.8M Grant for Ophthalmic Therapy R&D Advancement

                            Details : The SBIR grant will fund critical R&D activities, including multidose GMP toxicology studies in nonhuman primates for RO-104, a first-in-class fully human modular tri-specific biologic.

                            Brand Name : RO-104

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 15, 2024

                            Lead Product(s) : RO-104

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Recipient : RevOpsis Therapeutics

                            Deal Size : $1.8 million

                            Deal Type : Funding

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                            02

                            National Eye Institute

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                            Lead Product(s) : IVMED-85

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I/ Phase II

                            Recipient : iVeena

                            Deal Size : $0.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            iVeena Awarded NEI-SBIR Grant for Progressive Myopia Drug Candidate IVMED-85

                            Details : The grant will be used for the development of IVMED-85, an investigational eyedrop formulation containing copper intended for treatment of pediatric myopia. IVMED-85 will be the first eye drop inducing both scleral and corneal crosslinking for myopia con...

                            Brand Name : IVMED-85

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 26, 2023

                            Lead Product(s) : IVMED-85

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I/ Phase II

                            Recipient : iVeena

                            Deal Size : $0.3 million

                            Deal Type : Funding

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                            03

                            National Eye Institute

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                            Lead Product(s) : PTG-630

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : Praetego

                            Deal Size : $0.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Praetego Awarded $0.3M by National Eye Institute to Advance Novel Oral Drug for Diabetic Retinopathy

                            Details : Praetego's NEI grant expands PTG-630 to a third indication and builds upon promising findings in both Alzheimer's disease and diabetic peripheral neuropathy. PTG-630 has demonstrated remarkable potency as an AGE inhibitor.

                            Brand Name : PTG-630

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            March 01, 2023

                            Lead Product(s) : PTG-630

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : Praetego

                            Deal Size : $0.3 million

                            Deal Type : Funding

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                            04

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                            Lead Product(s) : TRE-515

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Trethera

                            Deal Size : $1.6 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Trethera Receives $1.6 Million National Eye Institute Grant for Continued Advancement of TRE-515 Optic Neuriti...

                            Details : TRE-515 is a novel first-in-class drug, which has been shown to prevent demyelination, and even facilitate remyelination, in multiple demyelinating disease mouse models. Furthermore, the FDA has designated TRE-515 an Orphan Drug in the treatment of ON.

                            Brand Name : TRE-515

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 19, 2022

                            Lead Product(s) : TRE-515

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Trethera

                            Deal Size : $1.6 million

                            Deal Type : Funding

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                            05

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                            Lead Product(s) : I27-Breg

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            NIH Scientists Discover New B Cell that Tempers Autoimmunity

                            Details : Infusions of purified IL-27 regulatory B cells (I27-Breg ) reduced symptoms in mouse models of multiple sclerosis (MS) and the eye disease autoimmune uveitis. The research suggests the cells may play a role in future human therapies.

                            Brand Name : I27-Breg

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            December 02, 2021

                            Lead Product(s) : I27-Breg

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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