[{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"Chimeron Bio","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2022","type":"Agreement","leadProduct":"mRNA-based Vaccine","moa":"SARS-CoV2 antigen","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"National Institute of Allergy and Infectious Diseases","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"National Institute of Allergy and Infectious Diseases \/ National Institute of Allergy and Infectious Diseases","highestDevelopmentStatusID":"4","companyTruncated":"National Institute of Allergy and Infectious Diseases \/ National Institute of Allergy and Infectious Diseases"},{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"Cocrystal 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Allergy and Infectious Diseases","sponsor":"ReAlta Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Trauma (Emergency, Injury, Surgery)","country":"","productType":"Peptide","year":"2024","type":"Collaboration","leadProduct":"RLS-0071","moa":"","graph1":"Trauma (Emergency, Injury, Surgery)","graph2":"Preclinical","graph3":"National Institute of Allergy and Infectious Diseases","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Trauma","amount2New":0,"dosageForm":"Infusion","sponsorNew":"National Institute of Allergy and Infectious Diseases \/ National Institute of Allergy and Infectious Diseases","highestDevelopmentStatusID":"4","companyTruncated":"National Institute of Allergy and Infectious Diseases \/ National Institute of Allergy and Infectious Diseases"},{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"Osivax","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious 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Find Clinical Drug Pipeline Developments & Deals by National Institute of Allergy and Infectious Diseases

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                          01

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : EV68-228-N, a human monoclonal IgG1 against the capsid of enterovirus D68 (EV-D68) designed as an intravenous therapeutic for the treatment of acute flaccid myelitis (AFM).

                          Brand Name : EV68-228-N

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 28, 2024

                          Lead Product(s) : EV68-228-N

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase I

                          Recipient : KBio

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The company will manufacture the PLX-R18 cell therapy and conduct in vitro and in vivo studies to develop it as a potential treatment for hematopoietic complications of the acute radiation syndrome.

                          Brand Name : PLX-R18

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 06, 2024

                          Lead Product(s) : Avoplacel

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Phase I

                          Recipient : Pluri

                          Deal Size : $4.2 million

                          Deal Type : Funding

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                          03

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Xocova® (ensitrelvir fumaric acid) is an antiviral drug for COVID-19 which suppresses the replication of SARS-CoV-2 by selectively inhibiting 3CL protease.

                          Brand Name : Xocova

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 13, 2024

                          Lead Product(s) : Ensitrelvir Fumaric Acid

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Recipient : Shionogi

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The collaboration aims to evaluate RLS-0071, a novel 15-amino acid peptide dual-targeting anti-inflammatory inhibitor, to mitigate gastrointestinal effects of ARS in a preclinical mouse model.

                          Brand Name : RLS-0071

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          March 28, 2024

                          Lead Product(s) : RLS-0071

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Preclinical

                          Recipient : ReAlta Life Sciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          05

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The funding will support preclinical studies evaluating the breadth of protection and immune response induced by the company’s lead, broad-spectrum influenza vaccine candidate, OVX836 against pandemic influenza strains.

                          Brand Name : OVX836

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          December 05, 2023

                          Lead Product(s) : OVX836

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : Osivax

                          Deal Size : $1.5 million

                          Deal Type : Funding

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                          06

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : OCU500 is a mucosal vaccine candidate which is delivered via two different mucosal routes, inhalation into the lungs and as a nasal spray, which is investigated for the treatment of COVID-19 and influenza (flu).

                          Brand Name : OCU500

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          October 10, 2023

                          Lead Product(s) : OCU500

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Ocugen

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The funding will be used to conduct nonclinical and clinical studies to advance its pan-coronavirus protease inhibitor ALG-097558, a potent, pan-coronavirus small molecule inhibitor of the viral 3CL protease, into future Phase 2/3 studies.

                          Brand Name : ALG-097558

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 03, 2023

                          Lead Product(s) : ALG-097558

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Recipient : Aligos Therapeutics

                          Deal Size : $8.5 million

                          Deal Type : Funding

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                          08

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The funding will be used for the development of a Group B Streptococcus vaccine using Omniose bioconjugate vaccine platform which enables the precise enzymatic attachment of virtually any bacterial polysaccharide antigen to engineered carrier proteins wi...

                          Brand Name : Undisclosed

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          September 27, 2023

                          Lead Product(s) : GBS Vaccine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Discovery

                          Recipient : Omniose

                          Deal Size : $3.0 million

                          Deal Type : Funding

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                          09

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The funding will be used to develop RVB-101, a genetically engineered cell therapy within a moisturizer formulation for the treatment for severe atopic dermatitis.

                          Brand Name : RVB-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 18, 2023

                          Lead Product(s) : RVB-101

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Recipient : ResVita Bio

                          Deal Size : $0.2 million

                          Deal Type : Funding

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                          10

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The agreement aims to evaluate the immunogenicity and efficacy of two IMUNON DNA-based Lassa virus vaccine candidates. NIAID will assess the efficacy of PlaCCine DNA constructs against Lassa virus in guinea pig and non-human primate disease models.

                          Brand Name : Undisclosed

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          August 24, 2023

                          Lead Product(s) : DNA-based Lassa Virus Vaccine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : Imunon

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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