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Diseases"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"RocketVax","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2024","type":"Collaboration","leadProduct":"RVX-sCPD9","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"KBio","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"","productType":"Large molecule","year":"2024","type":"Not 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Gene therapy","year":"2024","type":"Funding","leadProduct":"Neldaleucel","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institute on Aging","sponsor":"University of California","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Funding","leadProduct":"CNDR-51997","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institute on Aging","amount2":0.01,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institute on Aging \/ National Institute on Aging","highestDevelopmentStatusID":"14","companyTruncated":"National Institute on Aging \/ National Institute on Aging"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"Evoq Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"","productType":"Undisclosed","year":"2024","type":"Funding","leadProduct":"Undisclosed","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"TransCode Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Funding","leadProduct":"TTX-MC138","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Cancer Institute","sponsor":"Biosplice","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Collaboration","leadProduct":"Cirtuvivint","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Cancer 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Health"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"Orlance","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2024","type":"Funding","leadProduct":"MACH-1-based Vaccine","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"Allyx Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Funding","leadProduct":"ALX-001","moa":"","graph1":"Technology","graph2":"Phase 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I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institutes of Health","sponsor":"Vaxxas","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Vaccine","year":"2024","type":"Licensing Agreement","leadProduct":"RSV Vaccine","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"National Institutes of Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"National Institutes of Health \/ Vaxxas","highestDevelopmentStatusID":"14","companyTruncated":"National Institutes of Health \/ Vaxxas"}]

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                            01

                            National Institutes of Health

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                            National Institutes of Health

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : EydisBio

                            Deal Size : $0.5 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            EydisBio Wins $0.5M Grant for Alzheimer’s TAK1 Inhibitor Program

                            Details : The grant will support EydisBio's pioneering research into new therapeutic approaches for Alzheimer's disease, focusing on the inhibition of TGFβ-activated protein kinase 1 (TAK1).

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 23, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : EydisBio

                            Deal Size : $0.5 million

                            Deal Type : Funding

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                            02

                            National Institutes of Health

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                            Lead Product(s) : ALX-001

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Recipient : Allyx Therapeutics

                            Deal Size : $3.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Allyx Therapeutics Receives $3.3M NIH Grant for ALX-001 Clinical Studies

                            Details : The funding will support Allyx’s ALX-001, a highly-selective, first-in-class, synapse-targeted, disease-modifying oral therapy in development for Alzheimer’s disease and Parkinson’s disease.

                            Brand Name : BMS-9894923

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 15, 2024

                            Lead Product(s) : ALX-001

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Recipient : Allyx Therapeutics

                            Deal Size : $3.3 million

                            Deal Type : Funding

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                            03

                            National Eye Institute

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                            Lead Product(s) : RO-104

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Recipient : RevOpsis Therapeutics

                            Deal Size : $1.8 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            RevOpsis Wins $1.8M Grant for Ophthalmic Therapy R&D Advancement

                            Details : The SBIR grant will fund critical R&D activities, including multidose GMP toxicology studies in nonhuman primates for RO-104, a first-in-class fully human modular tri-specific biologic.

                            Brand Name : RO-104

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 15, 2024

                            Lead Product(s) : RO-104

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Recipient : RevOpsis Therapeutics

                            Deal Size : $1.8 million

                            Deal Type : Funding

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                            04

                            National Institutes of Health

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                            Lead Product(s) : MACH-1-based Vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : Orlance

                            Deal Size : $3.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Orlance Awarded $3.3M NIH Grant for MACH-1™ Enhanced Influenza Vaccine

                            Details : The proceeds will enable Orlance to leverage its innovative MACH-1 powdered vaccine and immunotherapy platform to address both seasonally-changing and highly-conserved influenza immunogens.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            October 10, 2024

                            Lead Product(s) : MACH-1-based Vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : Orlance

                            Deal Size : $3.3 million

                            Deal Type : Funding

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                            05

                            National Institute on Drug Abuse

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                            National Institute on Drug Abuse

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Preclinical

                            Recipient : EpiVario

                            Deal Size : $0.2 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            EpiVario Awarded SBIR Grant from NIH to Develop Treatments for Opioid Use Disorder

                            Details : The grant will be used to advance the company's research towards developing a novel epigenetic regulator as a treatment for opioid use disorder (OUD).

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 01, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Preclinical

                            Recipient : EpiVario

                            Deal Size : $0.2 million

                            Deal Type : Funding

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                            06

                            National Institutes of Health

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                            National Institutes of Health

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                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Recipient : Tiziana Life Sciences

                            Deal Size : $4.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Tiziana Receives $4M NIH Grant To Study Anti-CD3 in Alzheimer’s Disease

                            Details : The significant grant will fund a key research study over the next several years, advancing clinical studies of TZLS-401 (foralumab), anti-CD3 as a potential treatment for Alzheimer’s disease.

                            Brand Name : TZLS-401

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 19, 2024

                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Recipient : Tiziana Life Sciences

                            Deal Size : $4.0 million

                            Deal Type : Funding

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                            07

                            National Cancer Institute

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                            National Cancer Institute

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                            Lead Product(s) : Cirtuvivint

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Biosplice

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Biosplice Begins AML and MDS Trials Sponsored By National Cancer Institute

                            Details : The collaboration aims for Biosplice to expand its clinical candidate, SM08502 (cirtuvivint), as a standalone treatment and combination therapy in patients with AML and MDS.

                            Brand Name : SM08502

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 12, 2024

                            Lead Product(s) : Cirtuvivint

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Biosplice

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            08

                            National Institutes of Health

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                            National Institutes of Health

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                            Lead Product(s) : TTX-MC138

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Recipient : TransCode Therapeutics

                            Deal Size : $2.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            TransCode Wins $2M NIH Grant For Lead Candidate's Clinical Evaluation

                            Details : The proceeds will be used to support clinical development of TTX-MC138, a first-in-class therapeutic candidate, for the treatment of advanced solid tumors.

                            Brand Name : TTX-MC138

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 05, 2024

                            Lead Product(s) : TTX-MC138

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Recipient : TransCode Therapeutics

                            Deal Size : $2.0 million

                            Deal Type : Funding

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                            09

                            National Institutes of Health

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                            National Institutes of Health

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Discovery

                            Recipient : Evoq Therapeutics

                            Deal Size : $2.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            EVOQ Therapeutics Secures $2 Million NIH Grant

                            Details : The Company intends to use the proceeds to accelerate the development of its platform and advance novel therapies for autoimmune diseases.

                            Brand Name : Undisclosed

                            Molecule Type : Undisclosed

                            Upfront Cash : Undisclosed

                            August 29, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Discovery

                            Recipient : Evoq Therapeutics

                            Deal Size : $2.0 million

                            Deal Type : Funding

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                            10

                            National Institute on Aging

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                            National Institute on Aging

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                            Lead Product(s) : CNDR-51997

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : University of California

                            Deal Size : $6.9 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            NIH Awards $6.9 Million to Advance Potential Alzheimer’s Disease Treatment

                            Details : The proceeds will be used to prepare a potential disease-modifying Alzheimer’s treatment, CNDR-51997, which prevented tau from becoming detached from microtubules, for future clinical trials.

                            Brand Name : CNDR-51997

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 21, 2024

                            Lead Product(s) : CNDR-51997

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : University of California

                            Deal Size : $6.9 million

                            Deal Type : Funding

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