Lead Product(s) : NBI-921352
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase II
Sponsor : Xenon Pharmaceuticals Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Xenon Pharmaceuticals Provides Update on Partnered Program with Neurocrine Biosciences
Details : NBI-921352, an investigational, selective sodium channel 1.6 inhibitor (Nav1.6) currently under development in adult patients with focal onset seizures (FOS), failed to demonstrate meaningful reduction in seizure frequency.
Brand Name : NBI-921352
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 09, 2023
Lead Product(s) : NBI-921352
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase II
Sponsor : Xenon Pharmaceuticals Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NBI-921352 is an investigational, selective sodium channel 1.6 inhibitor (Nav1.6) currently under development for the potential treatment of SCN8A developmental and epileptic encephalopathy (SCN8A-DEE) in children and adults.
Brand Name : NBI-921352
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 02, 2022
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Study Phase : Phase II
Sponsor : Neurocrine Biosciences
Deal Size : $15.0 million
Deal Type : Collaboration
Details : Xenon has an ongoing collaboration with Neurocrine Biosciences to develop treatments for epilepsy. Neurocrine Biosciences has an exclusive license to XEN901, now known as NBI-921352, a selective Nav1.6 sodium channel inhibitor.
Brand Name : NBI-921352
Molecule Type : Small molecule
Upfront Cash : $6.7 million
January 12, 2022
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Highest Development Status : Phase II
Sponsor : Neurocrine Biosciences
Deal Size : $15.0 million
Deal Type : Collaboration
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $1,775.0 million
Deal Type : Collaboration
Details : Xenon ongoing collaboration with Neurocrine Biosciences to develop treatments including XEN901, now known as NBI-921352 a clinical stage selective Nav1.6 sodium channel inhibitor with potential in SCN8A developmental and epileptic encephalopathy and othe...
Brand Name : NBI-921352
Molecule Type : Small molecule
Upfront Cash : $50.0 million
September 08, 2021
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $1,775.0 million
Deal Type : Collaboration
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Xenon Pharmaceuticals Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : U.S. Food and Drug Administration (FDA) Requests Additional Non-Clinical Data to Support Dose Justification Before Initiation of a Phase II Clinical Trial with NBI-921352 in Pediatric SCN8A-DEE Patients.
Brand Name : XEN901
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 08, 2020
Lead Product(s) : NBI-921352
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Xenon Pharmaceuticals Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
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