6
ALL6
NextCureYear
6
ALL1
20231
20214
2020DEALS // DEV.
6
ALL6
DevelopmentsCountry
6
ALL6
U.S.A6
ALL6
InapplicableTherapeutic Area
6
ALL6
OncologyStudy Phase
6
ALL3
Phase II3
Phase I/ Phase IIDeal Type
6
ALL6
InapplicableProduct Type
6
ALL6
AntibodyDosage Form
6
ALL3
Injection2
Intravenous Infusion1
Intravenous InjectionLead Product
6
ALL6
NC318Target
6
ALL6
Siglec-15 /LAIR-1Lead Product(s) : NC318,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : NC318 is a humanized IgG1 mAb against S15 that blocks interactions of S15 with myeloid cells and T lymphocytes within the tumor microenvironment, relieving immune inhibitory signaling.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
December 09, 2023
Lead Product(s) : NC318,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : NC318
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : NC318 is a first-in-class immune medicine against S15, novel immunomodulatory target found on highly immunosuppressive cells called M2 macrophages in tumor microenvironment and on certain tumor types including lung, ovarian and head and neck cancers.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
November 13, 2021
Lead Product(s) : NC318
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : NC318
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
NextCure Provides Updates on NC318 Clinical Program
Details : NC318 is a first-in-class immunomedicine against S15, a novel immunomodulatory target found on highly immunosuppressive cells called M2 macrophages in the tumor microenvironment and on certain tumor types.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
December 17, 2020
Lead Product(s) : NC318
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
NextCure Provides an Interim Update of the Phase 2 Portion of the NC318 Monotherapy Phase 1/2 Trial
Details : Based on the current enrollment criteria and clinical response data, at this time the company does not plan to advance the non-small cell lung cancer (NSCLC) and ovarian cancer cohorts into the stage 2 portion of the Simon 2-stage trial.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
July 13, 2020
Lead Product(s) : NC318
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The early biomarker data suggest collectively the potential of NC318 to block S15-mediated immune suppression, as indicated by Increase of regulatory T cells in peripheral blood in the highest dose cohorts.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
May 29, 2020
Lead Product(s) : NC318
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : NC318
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
NextCure Provides Update on Clinical Trial Activities Due to Impact of COVID-19 Pandemic
Details : NextCure expects to report initial biomarker data from the Phase 1 portion of its Phase 1/2 NC318 monotherapy trial midyear.
Product Name : NC318
Product Type : Antibody
Upfront Cash : Inapplicable
April 13, 2020
Lead Product(s) : NC318
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable