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01

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : NC318 is a humanized IgG1 mAb against S15 that blocks interactions of S15 with myeloid cells and T lymphocytes within the tumor microenvironment, relieving immune inhibitory signaling.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

December 09, 2023

Lead Product(s) : NC318,Pembrolizumab

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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02

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : NC318 is a first-in-class immune medicine against S15, novel immunomodulatory target found on highly immunosuppressive cells called M2 macrophages in tumor microenvironment and on certain tumor types including lung, ovarian and head and neck cancers.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

November 13, 2021

Lead Product(s) : NC318

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : NC318 is a first-in-class immunomedicine against S15, a novel immunomodulatory target found on highly immunosuppressive cells called M2 macrophages in the tumor microenvironment and on certain tumor types.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

December 17, 2020

Lead Product(s) : NC318

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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04

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : Based on the current enrollment criteria and clinical response data, at this time the company does not plan to advance the non-small cell lung cancer (NSCLC) and ovarian cancer cohorts into the stage 2 portion of the Simon 2-stage trial.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

July 13, 2020

Lead Product(s) : NC318

Therapeutic Area : Oncology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : The early biomarker data suggest collectively the potential of NC318 to block S15-mediated immune suppression, as indicated by Increase of regulatory T cells in peripheral blood in the highest dose cohorts.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

May 29, 2020

Lead Product(s) : NC318

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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06

Peptide Therapy Summit
Not Confirmed
Peptide Therapy Summit
Not Confirmed

Details : NextCure expects to report initial biomarker data from the Phase 1 portion of its Phase 1/2 NC318 monotherapy trial midyear.

Product Name : NC318

Product Type : Antibody

Upfront Cash : Inapplicable

April 13, 2020

Lead Product(s) : NC318

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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